ID   FALX4_LITFA             Reviewed;          67 AA.
AC   B5LUQ5;
DT   10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT   14-OCT-2008, sequence version 1.
DT   25-MAY-2022, entry version 18.
DE   RecName: Full=Preprofallaxidin-4 {ECO:0000303|PubMed:18803332, ECO:0000312|EMBL:ACH53448.1};
DE   Contains:
DE     RecName: Full=Fallaxidin-4.2;
DE   Flags: Precursor;
OS   Litoria fallax (Eastern dwarf tree frog) (Hylomantis fallax).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Hyloidea; Hylidae; Pelodryadinae; Litoria.
OX   NCBI_TaxID=115422;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:ACH53448.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Skin {ECO:0000312|EMBL:ACH53448.1};
RX   PubMed=18803332; DOI=10.1002/rcm.3723;
RA   Jackway R.J., Bowie J.H., Bilusich D., Musgrave I.F., Surinya-Johnson K.H.,
RA   Tyler M.J., Eichinger P.C.H.;
RT   "The fallaxidin peptides from the skin secretion of the eastern dwarf tree
RT   frog Litoria fallax. Sequence determination by positive and negative ion
RT   electrospray mass spectrometry: antimicrobial activity and cDNA cloning of
RT   the fallaxidins.";
RL   Rapid Commun. Mass Spectrom. 22:3207-3216(2008).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:B5LUQ4}.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC       {ECO:0000269|PubMed:18803332}.
CC   -!- SIMILARITY: Belongs to the frog skin active peptide (FSAP) family.
CC       Dermaseptin subfamily. {ECO:0000255}.
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DR   EMBL; EU912530; ACH53448.1; -; mRNA.
DR   AlphaFoldDB; B5LUQ5; -.
DR   GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   InterPro; IPR004275; Frog_antimicrobial_propeptide.
DR   InterPro; IPR016322; FSAP.
DR   Pfam; PF03032; FSAP_sig_propep; 1.
DR   PIRSF; PIRSF001822; Dermaseptin_precursor; 1.
PE   2: Evidence at transcript level;
KW   Amphibian defense peptide; Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255, ECO:0000312|EMBL:ACH53448.1"
FT   PROPEP          23..46
FT                   /evidence="ECO:0000269|PubMed:18803332"
FT                   /id="PRO_0000361717"
FT   PEPTIDE         47..67
FT                   /note="Fallaxidin-4.2"
FT                   /id="PRO_0000361718"
FT   REGION          24..48
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   67 AA;  7647 MW;  896B18E0DB5BEBB0 CRC64;
     MASLKKFLFL VLFLGMVSLS ICDKEKREGE NEEEEEEHEE ESEEKRGLFS FLPKVIGVIG
     PLIHPPS