ID   FALX5_LITFA             Reviewed;          68 AA.
AC   B5LUQ6;
DT   10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT   14-OCT-2008, sequence version 1.
DT   25-MAY-2022, entry version 18.
DE   RecName: Full=Preprofallaxidin-5 {ECO:0000303|PubMed:18803332, ECO:0000312|EMBL:ACH53449.1};
DE   Contains:
DE     RecName: Full=Fallaxidin-5.1;
DE   Flags: Precursor;
OS   Litoria fallax (Eastern dwarf tree frog) (Hylomantis fallax).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Hyloidea; Hylidae; Pelodryadinae; Litoria.
OX   NCBI_TaxID=115422;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:ACH53449.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Skin {ECO:0000312|EMBL:ACH53449.1};
RX   PubMed=18803332; DOI=10.1002/rcm.3723;
RA   Jackway R.J., Bowie J.H., Bilusich D., Musgrave I.F., Surinya-Johnson K.H.,
RA   Tyler M.J., Eichinger P.C.H.;
RT   "The fallaxidin peptides from the skin secretion of the eastern dwarf tree
RT   frog Litoria fallax. Sequence determination by positive and negative ion
RT   electrospray mass spectrometry: antimicrobial activity and cDNA cloning of
RT   the fallaxidins.";
RL   Rapid Commun. Mass Spectrom. 22:3207-3216(2008).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P82881}.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC       {ECO:0000269|PubMed:18803332}.
CC   -!- SIMILARITY: Belongs to the frog skin active peptide (FSAP) family.
CC       Brevinin subfamily. {ECO:0000255}.
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DR   EMBL; EU912531; ACH53449.1; -; mRNA.
DR   AlphaFoldDB; B5LUQ6; -.
DR   GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   InterPro; IPR004275; Frog_antimicrobial_propeptide.
DR   Pfam; PF03032; FSAP_sig_propep; 1.
PE   2: Evidence at transcript level;
KW   Amidation; Amphibian defense peptide; Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255, ECO:0000312|EMBL:ACH53449.1"
FT   PROPEP          23..51
FT                   /evidence="ECO:0000269|PubMed:18803332"
FT                   /id="PRO_0000361719"
FT   PEPTIDE         52..64
FT                   /note="Fallaxidin-5.1"
FT                   /id="PRO_0000361720"
FT   PROPEP          68
FT                   /evidence="ECO:0000269|PubMed:18803332"
FT                   /id="PRO_0000361721"
FT   REGION          24..50
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        28..42
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         64
FT                   /note="Leucine amide"
FT                   /evidence="ECO:0000250|UniProtKB:P82881"
SQ   SEQUENCE   68 AA;  7741 MW;  51CD49A5761F5FF8 CRC64;
     MASLKKSLFL VLFLGFVSLS ICEEEKREDK EDEGENEEAE ENHEERSEEK RFLPLLASLV
     GGLLGKRS