FAM3A_MOUSE
ID FAM3A_MOUSE Reviewed; 230 AA.
AC Q9D8T0;
DT 19-SEP-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Protein FAM3A;
DE Flags: Precursor;
GN Name=Fam3a;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Pancreas;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the FAM3 family. {ECO:0000305}.
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DR EMBL; AK007715; BAB25208.1; -; mRNA.
DR EMBL; BC069871; AAH69871.1; -; mRNA.
DR CCDS; CCDS41022.1; -.
DR RefSeq; NP_001300654.1; NM_001313725.1.
DR RefSeq; NP_079749.1; NM_025473.4.
DR AlphaFoldDB; Q9D8T0; -.
DR SMR; Q9D8T0; -.
DR STRING; 10090.ENSMUSP00000109779; -.
DR PhosphoSitePlus; Q9D8T0; -.
DR EPD; Q9D8T0; -.
DR MaxQB; Q9D8T0; -.
DR PaxDb; Q9D8T0; -.
DR PRIDE; Q9D8T0; -.
DR ProteomicsDB; 275585; -.
DR TopDownProteomics; Q9D8T0; -.
DR Antibodypedia; 45386; 159 antibodies from 24 providers.
DR Ensembl; ENSMUST00000015427; ENSMUSP00000015427; ENSMUSG00000031399.
DR Ensembl; ENSMUST00000114142; ENSMUSP00000109778; ENSMUSG00000031399.
DR Ensembl; ENSMUST00000114143; ENSMUSP00000109779; ENSMUSG00000031399.
DR GeneID; 66294; -.
DR KEGG; mmu:66294; -.
DR UCSC; uc009tow.2; mouse.
DR CTD; 60343; -.
DR MGI; MGI:1913544; Fam3a.
DR VEuPathDB; HostDB:ENSMUSG00000031399; -.
DR eggNOG; ENOG502QUEU; Eukaryota.
DR GeneTree; ENSGT00950000183004; -.
DR InParanoid; Q9D8T0; -.
DR OrthoDB; 1295040at2759; -.
DR PhylomeDB; Q9D8T0; -.
DR TreeFam; TF353414; -.
DR BioGRID-ORCS; 66294; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Fam3a; mouse.
DR PRO; PR:Q9D8T0; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; Q9D8T0; protein.
DR Bgee; ENSMUSG00000031399; Expressed in otolith organ and 223 other tissues.
DR ExpressionAtlas; Q9D8T0; baseline and differential.
DR Genevisible; Q9D8T0; MM.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0019732; P:antifungal humoral response; ISO:MGI.
DR GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; ISO:MGI.
DR GO; GO:1905035; P:negative regulation of antifungal innate immune response; ISO:MGI.
DR GO; GO:0045721; P:negative regulation of gluconeogenesis; IEA:InterPro.
DR GO; GO:0046890; P:regulation of lipid biosynthetic process; IEA:InterPro.
DR CDD; cd13940; ILEI_FAM3C; 1.
DR InterPro; IPR039220; FAM3.
DR InterPro; IPR039221; FAM3A.
DR InterPro; IPR039477; ILEI/PANDER_dom.
DR InterPro; IPR039475; ILEI_FAM3C.
DR PANTHER; PTHR14592; PTHR14592; 1.
DR PANTHER; PTHR14592:SF11; PTHR14592:SF11; 1.
DR Pfam; PF15711; ILEI; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Reference proteome; Secreted; Signal.
FT SIGNAL 1..33
FT /evidence="ECO:0000255"
FT CHAIN 34..230
FT /note="Protein FAM3A"
FT /id="PRO_0000008749"
FT DISULFID 59..87
FT /evidence="ECO:0000250"
FT DISULFID 65..222
FT /evidence="ECO:0000250"
SQ SEQUENCE 230 AA; 25394 MW; 6239418ED8258087 CRC64;
MRLAGPLRIV ALIIIMGLTW ILVTILLGGP GVGLPRIQQF FTSPENSVTA EPRARKYKCG
LPQPCPEEHL SFRIVSGAAN VIGPKICLED KMLMSSVKDN VGRGLNIALV NGVSGELLEA
RAFDMWAGDV NDLLKFIRPL HEGTLVFVAS YDDPATKMNE ETRKLFSELG SRNAKDLAFR
DSWVFVGAKG VQNKSPFEQH MKNSKHTNKY EGWPEALEME GCIPRRSIAG
