ID   FAM3C_BOVIN             Reviewed;         227 AA.
AC   A5PKI3;
DT   10-AUG-2010, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=Protein FAM3C;
DE   AltName: Full=Interleukin-like EMT inducer;
DE   Flags: Precursor;
GN   Name=FAM3C; Synonyms=ILEI;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Basal ganglia;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be involved in retinal laminar formation. Promotes
CC       epithelial to mesenchymal transition (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Cytoplasmic vesicle
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the FAM3 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC142498; AAI42499.1; -; mRNA.
DR   RefSeq; NP_001092617.1; NM_001099147.1.
DR   AlphaFoldDB; A5PKI3; -.
DR   SMR; A5PKI3; -.
DR   STRING; 9913.ENSBTAP00000030039; -.
DR   PaxDb; A5PKI3; -.
DR   PRIDE; A5PKI3; -.
DR   Ensembl; ENSBTAT00000030051; ENSBTAP00000030039; ENSBTAG00000007976.
DR   Ensembl; ENSBTAT00000073296; ENSBTAP00000058101; ENSBTAG00000007976.
DR   GeneID; 615690; -.
DR   KEGG; bta:615690; -.
DR   CTD; 10447; -.
DR   VEuPathDB; HostDB:ENSBTAG00000007976; -.
DR   VGNC; VGNC:28811; FAM3C.
DR   eggNOG; ENOG502QQR8; Eukaryota.
DR   GeneTree; ENSGT00950000183004; -.
DR   HOGENOM; CLU_099478_0_0_1; -.
DR   InParanoid; A5PKI3; -.
DR   OMA; EINVEFK; -.
DR   OrthoDB; 1295040at2759; -.
DR   TreeFam; TF353414; -.
DR   Reactome; R-BTA-114608; Platelet degranulation.
DR   Proteomes; UP000009136; Chromosome 4.
DR   Bgee; ENSBTAG00000007976; Expressed in rumen papilla and 106 other tissues.
DR   GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR   GO; GO:0045721; P:negative regulation of gluconeogenesis; IEA:InterPro.
DR   CDD; cd13940; ILEI_FAM3C; 1.
DR   InterPro; IPR039220; FAM3.
DR   InterPro; IPR039219; FAM3C.
DR   InterPro; IPR039477; ILEI/PANDER_dom.
DR   InterPro; IPR039475; ILEI_FAM3C.
DR   PANTHER; PTHR14592; PTHR14592; 1.
DR   PANTHER; PTHR14592:SF10; PTHR14592:SF10; 1.
DR   Pfam; PF15711; ILEI; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasmic vesicle; Developmental protein; Disulfide bond; Oncogene;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..227
FT                   /note="Protein FAM3C"
FT                   /id="PRO_0000395981"
FT   DISULFID        58..86
FT                   /evidence="ECO:0000250"
FT   DISULFID        64..221
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   227 AA;  24797 MW;  3F484AEDF9B09A1E CRC64;
     MRVAGAAKLV VAVAVFLLTF YVISQVFEIK MDASLGNLFA RSALDAVVRS TKPPRYKCGI
     SKACPEKHFA FKMASGAANV VGPKICLEDN VLMSGVKNNV GRGINVALVN GKTGELIDTR
     FFDMWGGNVA PFIEFLKAIQ DGTIVLMGTY DDGATKLNDE ARRLIAELGS TSITHLGFRD
     NWVFCGGKGI KTKSPFEQHI KNNKDTNKYE GWPEVVEMEG CIPQKQD