ID   FAM3C_DANRE             Reviewed;         227 AA.
AC   Q7ZYY4; Q6NY75;
DT   10-AUG-2010, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Protein FAM3C;
DE   Flags: Precursor;
GN   Name=fam3c; ORFNames=si:dkey-159a18.2;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB; TISSUE=Kidney;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in retinal laminar formation. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the FAM3 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH66710.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; BX890616; CAI20694.1; -; Genomic_DNA.
DR   EMBL; BC044170; AAH44170.1; -; mRNA.
DR   EMBL; BC066710; AAH66710.1; ALT_INIT; mRNA.
DR   RefSeq; NP_997890.1; NM_212725.1.
DR   AlphaFoldDB; Q7ZYY4; -.
DR   SMR; Q7ZYY4; -.
DR   STRING; 7955.ENSDARP00000091640; -.
DR   PaxDb; Q7ZYY4; -.
DR   Ensembl; ENSDART00000100867; ENSDARP00000091640; ENSDARG00000056152.
DR   GeneID; 334205; -.
DR   KEGG; dre:334205; -.
DR   CTD; 10447; -.
DR   ZFIN; ZDB-GENE-030131-6137; fam3c.
DR   eggNOG; ENOG502QQR8; Eukaryota.
DR   GeneTree; ENSGT00950000183004; -.
DR   HOGENOM; CLU_099478_0_0_1; -.
DR   InParanoid; Q7ZYY4; -.
DR   OMA; EINVEFK; -.
DR   OrthoDB; 1295040at2759; -.
DR   PhylomeDB; Q7ZYY4; -.
DR   TreeFam; TF353414; -.
DR   Reactome; R-DRE-114608; Platelet degranulation.
DR   PRO; PR:Q7ZYY4; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 4.
DR   Bgee; ENSDARG00000056152; Expressed in early embryo and 30 other tissues.
DR   ExpressionAtlas; Q7ZYY4; baseline and differential.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0045721; P:negative regulation of gluconeogenesis; IEA:InterPro.
DR   CDD; cd13940; ILEI_FAM3C; 1.
DR   InterPro; IPR039220; FAM3.
DR   InterPro; IPR039219; FAM3C.
DR   InterPro; IPR039477; ILEI/PANDER_dom.
DR   InterPro; IPR039475; ILEI_FAM3C.
DR   PANTHER; PTHR14592; PTHR14592; 1.
DR   PANTHER; PTHR14592:SF10; PTHR14592:SF10; 1.
DR   Pfam; PF15711; ILEI; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Disulfide bond; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..30
FT                   /evidence="ECO:0000255"
FT   CHAIN           31..227
FT                   /note="Protein FAM3C"
FT                   /id="PRO_0000395983"
FT   DISULFID        58..86
FT                   /evidence="ECO:0000250"
FT   DISULFID        64..221
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   227 AA;  24921 MW;  4999A0F191A292C1 CRC64;
     MMRAGGLLKL GVLVSVLFVA VFLAFELLES NMNFNLGKVF TRYAPPDAVP TRPLRHKCGL
     SKSCPEDHFA FKITSGAASV VGPKMCFQDN VIMSGVKNNI GRGINIALLN GKTGELTKTD
     SFDMWTGDVN LLIKFLKDIE DGSIVMMATF DDPATKMNDE ARNLIADLGS SSISILGFRD
     NWVFVGGKGI KTKSPFEQHI KNNAETNKYE GWPEVLEMEG CIPIKHD