FAM3C_HUMAN
ID FAM3C_HUMAN Reviewed; 227 AA.
AC Q92520; A6NDN2; A8K3R7;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1997, sequence version 1.
DT 03-AUG-2022, entry version 169.
DE RecName: Full=Protein FAM3C;
DE AltName: Full=Interleukin-like EMT inducer;
DE Flags: Precursor;
GN Name=FAM3C; Synonyms=ILEI; ORFNames=GS3786;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Bone;
RA Ohno I., Hashimoto J., Takaoka K., Ochi T., Okubo K., Matsubara K.;
RT "The cloning of a cDNA for novel genes expressed in human osteoblast.";
RL Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, Duodenum, and Muscle;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP IDENTIFICATION.
RX PubMed=12160727; DOI=10.1006/geno.2002.6816;
RA Zhu Y., Xu G., Patel A., McLaughlin M.M., Silverman C., Knecht K.A.,
RA Sweitzer S., Li X., McDonnell P., Mirabile R., Zimmerman D., Boyce R.,
RA Tierney L.A., Hu E., Livi G.P., Wolf B.A., Abdel-Meguid S.S., Rose G.D.,
RA Aurora R., Hensley P., Briggs M., Young P.R.;
RT "Cloning, expression, and initial characterization of a novel cytokine-like
RT gene family.";
RL Genomics 80:144-150(2002).
RN [7]
RP TISSUE SPECIFICITY, SUBCELLULAR LOCATION, AND UP-REGULATION IN BREAST
RP CANCER.
RX PubMed=16959614; DOI=10.1016/j.ccr.2006.07.020;
RA Waerner T., Alacakaptan M., Tamir I., Oberauer R., Gal A., Brabletz T.,
RA Schreiber M., Jechlinger M., Beug H.;
RT "ILEI: a cytokine essential for EMT, tumor formation, and late events in
RT metastasis in epithelial cells.";
RL Cancer Cell 10:227-239(2006).
RN [8]
RP UP-REGULATION IN BREAST CANCER.
RX PubMed=19015638; DOI=10.1038/onc.2008.418;
RA Lahsnig C., Mikula M., Petz M., Zulehner G., Schneller D., van Zijl F.,
RA Huber H., Csiszar A., Beug H., Mikulits W.;
RT "ILEI requires oncogenic Ras for the epithelial to mesenchymal transition
RT of hepatocytes and liver carcinoma progression.";
RL Oncogene 28:638-650(2009).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [10]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
RN [11]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=25944712; DOI=10.1002/pmic.201400617;
RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D.,
RA Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT "N-terminome analysis of the human mitochondrial proteome.";
RL Proteomics 15:2519-2524(2015).
CC -!- FUNCTION: May be involved in retinal laminar formation. Promotes
CC epithelial to mesenchymal transition.
CC -!- INTERACTION:
CC Q92520; Q8IVF2-3: AHNAK2; NbExp=3; IntAct=EBI-2876774, EBI-12078468;
CC Q92520; Q86WK6: AMIGO1; NbExp=3; IntAct=EBI-2876774, EBI-19125216;
CC Q92520; P41181: AQP2; NbExp=3; IntAct=EBI-2876774, EBI-12701138;
CC Q92520; Q13323: BIK; NbExp=3; IntAct=EBI-2876774, EBI-700794;
CC Q92520; Q12982: BNIP2; NbExp=3; IntAct=EBI-2876774, EBI-752094;
CC Q92520; Q12983: BNIP3; NbExp=3; IntAct=EBI-2876774, EBI-749464;
CC Q92520; Q6ZS10: CLEC17A; NbExp=3; IntAct=EBI-2876774, EBI-11977093;
CC Q92520; Q9UHP7-3: CLEC2D; NbExp=3; IntAct=EBI-2876774, EBI-11749983;
CC Q92520; Q9ULY5: CLEC4E; NbExp=3; IntAct=EBI-2876774, EBI-12807010;
CC Q92520; Q96BA8: CREB3L1; NbExp=4; IntAct=EBI-2876774, EBI-6942903;
CC Q92520; P78310: CXADR; NbExp=3; IntAct=EBI-2876774, EBI-747931;
CC Q92520; P00387: CYB5R3; NbExp=3; IntAct=EBI-2876774, EBI-1046040;
CC Q92520; Q9GZR5: ELOVL4; NbExp=3; IntAct=EBI-2876774, EBI-18535450;
CC Q92520; Q9Y282: ERGIC3; NbExp=3; IntAct=EBI-2876774, EBI-781551;
CC Q92520; P60508: ERVFRD-1; NbExp=3; IntAct=EBI-2876774, EBI-17973325;
CC Q92520; P34910-2: EVI2B; NbExp=3; IntAct=EBI-2876774, EBI-17640610;
CC Q92520; Q5JX71: FAM209A; NbExp=3; IntAct=EBI-2876774, EBI-18304435;
CC Q92520; P12314: FCGR1A; NbExp=3; IntAct=EBI-2876774, EBI-2869867;
CC Q92520; P55899: FCGRT; NbExp=3; IntAct=EBI-2876774, EBI-2833934;
CC Q92520; O15552: FFAR2; NbExp=3; IntAct=EBI-2876774, EBI-2833872;
CC Q92520; Q9Y680: FKBP7; NbExp=3; IntAct=EBI-2876774, EBI-3918971;
CC Q92520; Q8TBE3: FNDC9; NbExp=3; IntAct=EBI-2876774, EBI-12142257;
CC Q92520; Q6P531: GGT6; NbExp=3; IntAct=EBI-2876774, EBI-2868927;
CC Q92520; O95377: GJB5; NbExp=3; IntAct=EBI-2876774, EBI-3909454;
CC Q92520; O15529: GPR42; NbExp=3; IntAct=EBI-2876774, EBI-18076404;
CC Q92520; Q8TED1: GPX8; NbExp=3; IntAct=EBI-2876774, EBI-11721746;
CC Q92520; Q9UM44: HHLA2; NbExp=3; IntAct=EBI-2876774, EBI-2867874;
CC Q92520; P16871: IL7R; NbExp=3; IntAct=EBI-2876774, EBI-80490;
CC Q92520; P16389-2: KCNA2; NbExp=3; IntAct=EBI-2876774, EBI-11987131;
CC Q92520; P43628: KIR2DL3; NbExp=3; IntAct=EBI-2876774, EBI-8632435;
CC Q92520; Q8N386: LRRC25; NbExp=3; IntAct=EBI-2876774, EBI-11304917;
CC Q92520; Q9GZY8-5: MFF; NbExp=3; IntAct=EBI-2876774, EBI-11956541;
CC Q92520; Q15223: NECTIN1; NbExp=3; IntAct=EBI-2876774, EBI-1771314;
CC Q92520; Q13113: PDZK1IP1; NbExp=3; IntAct=EBI-2876774, EBI-716063;
CC Q92520; Q8NC24: RELL2; NbExp=3; IntAct=EBI-2876774, EBI-10269209;
CC Q92520; Q96TC7: RMDN3; NbExp=3; IntAct=EBI-2876774, EBI-1056589;
CC Q92520; O60930: RNASEH1; NbExp=3; IntAct=EBI-2876774, EBI-2372399;
CC Q92520; Q9NR31: SAR1A; NbExp=3; IntAct=EBI-2876774, EBI-3920694;
CC Q92520; Q9NY72: SCN3B; NbExp=3; IntAct=EBI-2876774, EBI-17247926;
CC Q92520; Q3KNW5: SLC10A6; NbExp=3; IntAct=EBI-2876774, EBI-18159983;
CC Q92520; P54219-3: SLC18A1; NbExp=3; IntAct=EBI-2876774, EBI-17595455;
CC Q92520; Q9NQQ7-3: SLC35C2; NbExp=3; IntAct=EBI-2876774, EBI-17295964;
CC Q92520; Q9NP94: SLC39A2; NbExp=3; IntAct=EBI-2876774, EBI-12898013;
CC Q92520; Q99523: SORT1; NbExp=3; IntAct=EBI-2876774, EBI-1057058;
CC Q92520; O43278-2: SPINT1; NbExp=3; IntAct=EBI-2876774, EBI-12078338;
CC Q92520; Q8WWF3: SSMEM1; NbExp=3; IntAct=EBI-2876774, EBI-17280858;
CC Q92520; Q16623: STX1A; NbExp=3; IntAct=EBI-2876774, EBI-712466;
CC Q92520; Q8N6K0: TEX29; NbExp=3; IntAct=EBI-2876774, EBI-19027521;
CC Q92520; Q96CE8: TM4SF18; NbExp=3; IntAct=EBI-2876774, EBI-13351685;
CC Q92520; Q9NWD8: TMEM248; NbExp=3; IntAct=EBI-2876774, EBI-10314986;
CC Q92520; Q96B21: TMEM45B; NbExp=3; IntAct=EBI-2876774, EBI-3923061;
CC Q92520; Q6P5X7-2: TMEM71; NbExp=3; IntAct=EBI-2876774, EBI-12886878;
CC Q92520; Q96HE8: TMEM80; NbExp=3; IntAct=EBI-2876774, EBI-11742770;
CC Q92520; O15393-2: TMPRSS2; NbExp=3; IntAct=EBI-2876774, EBI-12345267;
CC Q92520; Q9Y320: TMX2; NbExp=3; IntAct=EBI-2876774, EBI-6447886;
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Cytoplasmic vesicle
CC {ECO:0000269|PubMed:16959614}. Note=Cytoplasmic in some cancer cells.
CC -!- TISSUE SPECIFICITY: Present in most secretory epithelia (at protein
CC level). {ECO:0000269|PubMed:16959614}.
CC -!- MISCELLANEOUS: Up-regulation and/or mislocalization in breast cancer
CC and liver carcinoma cells is strongly correlated with metastasis
CC formation and survival.
CC -!- SIMILARITY: Belongs to the FAM3 family. {ECO:0000305}.
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DR EMBL; D87120; BAA13251.1; -; mRNA.
DR EMBL; AK290682; BAF83371.1; -; mRNA.
DR EMBL; AK292731; BAF85420.1; -; mRNA.
DR EMBL; AC006364; AAQ96872.1; -; Genomic_DNA.
DR EMBL; CH471070; EAW83558.1; -; Genomic_DNA.
DR EMBL; BC024200; AAH24200.1; -; mRNA.
DR EMBL; BC046932; AAH46932.1; -; mRNA.
DR EMBL; BC068526; AAH68526.1; -; mRNA.
DR CCDS; CCDS5782.1; -.
DR RefSeq; NP_001035109.1; NM_001040020.1.
DR RefSeq; NP_055703.1; NM_014888.2.
DR RefSeq; XP_011514038.1; XM_011515736.2.
DR RefSeq; XP_011514039.1; XM_011515737.2.
DR PDB; 5LC2; X-ray; 1.80 A; A/B=55-227.
DR PDBsum; 5LC2; -.
DR AlphaFoldDB; Q92520; -.
DR SMR; Q92520; -.
DR BioGRID; 115712; 101.
DR IntAct; Q92520; 72.
DR MINT; Q92520; -.
DR STRING; 9606.ENSP00000353025; -.
DR iPTMnet; Q92520; -.
DR PhosphoSitePlus; Q92520; -.
DR SwissPalm; Q92520; -.
DR BioMuta; FAM3C; -.
DR DMDM; 3334194; -.
DR EPD; Q92520; -.
DR jPOST; Q92520; -.
DR MassIVE; Q92520; -.
DR MaxQB; Q92520; -.
DR PaxDb; Q92520; -.
DR PeptideAtlas; Q92520; -.
DR PRIDE; Q92520; -.
DR ProteomicsDB; 75279; -.
DR TopDownProteomics; Q92520; -.
DR Antibodypedia; 31703; 284 antibodies from 34 providers.
DR DNASU; 10447; -.
DR Ensembl; ENST00000359943.8; ENSP00000353025.3; ENSG00000196937.11.
DR GeneID; 10447; -.
DR KEGG; hsa:10447; -.
DR MANE-Select; ENST00000359943.8; ENSP00000353025.3; NM_014888.3; NP_055703.1.
DR UCSC; uc003vjx.4; human.
DR CTD; 10447; -.
DR DisGeNET; 10447; -.
DR GeneCards; FAM3C; -.
DR HGNC; HGNC:18664; FAM3C.
DR HPA; ENSG00000196937; Low tissue specificity.
DR MIM; 608618; gene.
DR neXtProt; NX_Q92520; -.
DR OpenTargets; ENSG00000196937; -.
DR PharmGKB; PA38627; -.
DR VEuPathDB; HostDB:ENSG00000196937; -.
DR eggNOG; ENOG502QQR8; Eukaryota.
DR GeneTree; ENSGT00950000183004; -.
DR HOGENOM; CLU_099478_0_0_1; -.
DR InParanoid; Q92520; -.
DR OMA; EINVEFK; -.
DR OrthoDB; 1295040at2759; -.
DR PhylomeDB; Q92520; -.
DR TreeFam; TF353414; -.
DR PathwayCommons; Q92520; -.
DR Reactome; R-HSA-114608; Platelet degranulation.
DR SignaLink; Q92520; -.
DR BioGRID-ORCS; 10447; 15 hits in 1034 CRISPR screens.
DR ChiTaRS; FAM3C; human.
DR GeneWiki; FAM3C; -.
DR GenomeRNAi; 10447; -.
DR Pharos; Q92520; Tbio.
DR PRO; PR:Q92520; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q92520; protein.
DR Bgee; ENSG00000196937; Expressed in jejunal mucosa and 209 other tissues.
DR ExpressionAtlas; Q92520; baseline and differential.
DR Genevisible; Q92520; HS.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; IDA:HPA.
DR GO; GO:0031089; C:platelet dense granule lumen; TAS:Reactome.
DR GO; GO:0005125; F:cytokine activity; NAS:UniProtKB.
DR GO; GO:0045721; P:negative regulation of gluconeogenesis; IEA:InterPro.
DR CDD; cd13940; ILEI_FAM3C; 1.
DR InterPro; IPR039220; FAM3.
DR InterPro; IPR039219; FAM3C.
DR InterPro; IPR039477; ILEI/PANDER_dom.
DR InterPro; IPR039475; ILEI_FAM3C.
DR PANTHER; PTHR14592; PTHR14592; 1.
DR PANTHER; PTHR14592:SF10; PTHR14592:SF10; 1.
DR Pfam; PF15711; ILEI; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytoplasmic vesicle; Developmental protein; Disulfide bond;
KW Oncogene; Reference proteome; Secreted; Signal.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..227
FT /note="Protein FAM3C"
FT /id="PRO_0000008752"
FT DISULFID 58..86
FT /evidence="ECO:0000250"
FT DISULFID 64..221
FT /evidence="ECO:0000250"
FT HELIX 57..59
FT /evidence="ECO:0007829|PDB:5LC2"
FT STRAND 66..74
FT /evidence="ECO:0007829|PDB:5LC2"
FT TURN 78..80
FT /evidence="ECO:0007829|PDB:5LC2"
FT STRAND 84..87
FT /evidence="ECO:0007829|PDB:5LC2"
FT STRAND 90..93
FT /evidence="ECO:0007829|PDB:5LC2"
FT TURN 95..98
FT /evidence="ECO:0007829|PDB:5LC2"
FT STRAND 102..109
FT /evidence="ECO:0007829|PDB:5LC2"
FT TURN 111..113
FT /evidence="ECO:0007829|PDB:5LC2"
FT STRAND 116..122
FT /evidence="ECO:0007829|PDB:5LC2"
FT TURN 124..126
FT /evidence="ECO:0007829|PDB:5LC2"
FT HELIX 130..137
FT /evidence="ECO:0007829|PDB:5LC2"
FT STRAND 144..151
FT /evidence="ECO:0007829|PDB:5LC2"
FT HELIX 159..166
FT /evidence="ECO:0007829|PDB:5LC2"
FT TURN 167..169
FT /evidence="ECO:0007829|PDB:5LC2"
FT HELIX 172..175
FT /evidence="ECO:0007829|PDB:5LC2"
FT STRAND 181..187
FT /evidence="ECO:0007829|PDB:5LC2"
FT STRAND 197..200
FT /evidence="ECO:0007829|PDB:5LC2"
FT TURN 204..206
FT /evidence="ECO:0007829|PDB:5LC2"
FT STRAND 208..212
FT /evidence="ECO:0007829|PDB:5LC2"
FT STRAND 217..223
FT /evidence="ECO:0007829|PDB:5LC2"
SQ SEQUENCE 227 AA; 24680 MW; 6DC94B259052647F CRC64;
MRVAGAAKLV VAVAVFLLTF YVISQVFEIK MDASLGNLFA RSALDTAARS TKPPRYKCGI
SKACPEKHFA FKMASGAANV VGPKICLEDN VLMSGVKNNV GRGINVALAN GKTGEVLDTK
YFDMWGGDVA PFIEFLKAIQ DGTIVLMGTY DDGATKLNDE ARRLIADLGS TSITNLGFRD
NWVFCGGKGI KTKSPFEQHI KNNKDTNKYE GWPEVVEMEG CIPQKQD
