ID   FAM3C_RAT               Reviewed;         227 AA.
AC   Q810F4;
DT   10-AUG-2010, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Protein FAM3C;
DE   AltName: Full=Interleukin-like EMT inducer;
DE   Flags: Precursor;
GN   Name=Fam3c; Synonyms=Ilei;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Wistar; TISSUE=Bone marrow;
RA   Buki K.G., Vaananen K.;
RT   "Novel genes in rat bone marrow.";
RL   Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be involved in retinal laminar formation. Promotes
CC       epithelial to mesenchymal transition (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Cytoplasmic vesicle
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the FAM3 family. {ECO:0000305}.
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DR   EMBL; AY228475; AAO73558.1; -; mRNA.
DR   RefSeq; NP_942066.1; NM_198771.1.
DR   AlphaFoldDB; Q810F4; -.
DR   SMR; Q810F4; -.
DR   STRING; 10116.ENSRNOP00000007886; -.
DR   jPOST; Q810F4; -.
DR   PaxDb; Q810F4; -.
DR   PRIDE; Q810F4; -.
DR   GeneID; 312159; -.
DR   KEGG; rno:312159; -.
DR   UCSC; RGD:735193; rat.
DR   CTD; 10447; -.
DR   RGD; 735193; Fam3c.
DR   VEuPathDB; HostDB:ENSRNOG00000060349; -.
DR   eggNOG; ENOG502QQR8; Eukaryota.
DR   HOGENOM; CLU_099478_0_0_1; -.
DR   InParanoid; Q810F4; -.
DR   OMA; EINVEFK; -.
DR   OrthoDB; 1295040at2759; -.
DR   PhylomeDB; Q810F4; -.
DR   TreeFam; TF353414; -.
DR   Reactome; R-RNO-114608; Platelet degranulation.
DR   PRO; PR:Q810F4; -.
DR   Proteomes; UP000002494; Chromosome 4.
DR   Bgee; ENSRNOG00000060349; Expressed in stomach and 20 other tissues.
DR   ExpressionAtlas; Q810F4; baseline and differential.
DR   Genevisible; Q810F4; RN.
DR   GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR   GO; GO:0045721; P:negative regulation of gluconeogenesis; IEA:InterPro.
DR   CDD; cd13940; ILEI_FAM3C; 1.
DR   InterPro; IPR039220; FAM3.
DR   InterPro; IPR039219; FAM3C.
DR   InterPro; IPR039477; ILEI/PANDER_dom.
DR   InterPro; IPR039475; ILEI_FAM3C.
DR   PANTHER; PTHR14592; PTHR14592; 1.
DR   PANTHER; PTHR14592:SF10; PTHR14592:SF10; 1.
DR   Pfam; PF15711; ILEI; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasmic vesicle; Developmental protein; Disulfide bond; Oncogene;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..227
FT                   /note="Protein FAM3C"
FT                   /id="PRO_0000395982"
FT   DISULFID        58..86
FT                   /evidence="ECO:0000250"
FT   DISULFID        64..221
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   227 AA;  24714 MW;  43A84E5B3266D44A CRC64;
     MRVAGAAKLV VAVAVFLLTF YVISQVFEIK MDASLGSLFA RSALDSAIRS TKPPRYKCGI
     SKACPEKHFA FKMASGAANV VGPKICLEDN VLMSGVKNNV GRGINVALVN GKTGDVIDTK
     YFDMWGGDVA PFIEFLKTIQ DGTVVLMATY DDGATKLTEE ARRLIAELGS TSITSLGFRD
     NWVFCGGKGI KTKSPFEQHI KNNKDTNKYE GWPEVVEMEG CIPQKQD