ID   FAM3C_XENLA             Reviewed;         229 AA.
AC   Q6GQC1;
DT   10-AUG-2010, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 50.
DE   RecName: Full=Protein FAM3C;
DE   Flags: Precursor;
GN   Name=fam3c;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   DEVELOPMENTAL STAGE, TISSUE SPECIFICITY, AND FUNCTION.
RX   PubMed=20059962; DOI=10.1016/j.bbrc.2009.12.180;
RA   Katahira T., Nakagiri S., Terada K., Furukawa T.;
RT   "Secreted factor FAM3C (ILEI) is involved in retinal laminar formation.";
RL   Biochem. Biophys. Res. Commun. 392:301-306(2010).
CC   -!- FUNCTION: Involved in retinal laminar formation.
CC       {ECO:0000269|PubMed:20059962}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed in the retinal ganglion cell layer.
CC       {ECO:0000269|PubMed:20059962}.
CC   -!- DEVELOPMENTAL STAGE: Expression starts at stage 32.
CC       {ECO:0000269|PubMed:20059962}.
CC   -!- SIMILARITY: Belongs to the FAM3 family. {ECO:0000305}.
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DR   EMBL; BC072824; AAH72824.1; -; mRNA.
DR   RefSeq; NP_001085479.1; NM_001092010.1.
DR   RefSeq; XP_018106406.1; XM_018250917.1.
DR   AlphaFoldDB; Q6GQC1; -.
DR   SMR; Q6GQC1; -.
DR   MaxQB; Q6GQC1; -.
DR   GeneID; 443905; -.
DR   KEGG; xla:443905; -.
DR   CTD; 443905; -.
DR   Xenbase; XB-GENE-943499; fam3c.L.
DR   OMA; MCLEDIL; -.
DR   OrthoDB; 1295040at2759; -.
DR   Proteomes; UP000186698; Chromosome 3L.
DR   Bgee; 443905; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0045721; P:negative regulation of gluconeogenesis; IEA:InterPro.
DR   CDD; cd13940; ILEI_FAM3C; 1.
DR   InterPro; IPR039220; FAM3.
DR   InterPro; IPR039219; FAM3C.
DR   InterPro; IPR039477; ILEI/PANDER_dom.
DR   InterPro; IPR039475; ILEI_FAM3C.
DR   PANTHER; PTHR14592; PTHR14592; 1.
DR   PANTHER; PTHR14592:SF10; PTHR14592:SF10; 1.
DR   Pfam; PF15711; ILEI; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Disulfide bond; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..229
FT                   /note="Protein FAM3C"
FT                   /id="PRO_0000395984"
FT   DISULFID        59..87
FT                   /evidence="ECO:0000250"
FT   DISULFID        65..222
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   229 AA;  25155 MW;  CFE9596D0B2ABCF3 CRC64;
     MRIAGAIKFV VAVALFLLTF YVISQVFEIK SYTNLGNIFV RSAIDTVAHP TTKAPRYRCG
     ISKVCPEKHF AFKIASGAAN VVGPKICVDD NILMSGVKNN VGRGINTALV NGKTGALIET
     TYHDLWGGEV GPFIEFLKKI PDGTIVLMAT YDDGATKLND DARKRISELG STLINVLAFR
     DNWVFVGGKG IKTKSPFEQH IKNNKDTNKY EGWPEVVEME GCIPQKLNE