FAM3D_MOUSE
ID FAM3D_MOUSE Reviewed; 223 AA.
AC P97805; Q8R009; Q8R1F2;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 19-SEP-2002, sequence version 2.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Protein FAM3D;
DE AltName: Full=Oncoprotein-induced protein 1;
DE AltName: Full=Protein EF-7;
DE Flags: Precursor;
GN Name=Fam3d {ECO:0000312|MGI:MGI:1201784};
GN Synonyms=Oit1 {ECO:0000312|MGI:MGI:1201784};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Tongue;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Colon, and Salivary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 109-223.
RC STRAIN=BALB/cJ;
RX PubMed=9032278; DOI=10.1128/mcb.17.3.1503;
RA Fu X., Kamps M.P.;
RT "E2a-Pbx1 induces aberrant expression of tissue-specific and
RT developmentally regulated genes when expressed in NIH 3T3 fibroblasts.";
RL Mol. Cell. Biol. 17:1503-1512(1997).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the FAM3 family. {ECO:0000305}.
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DR EMBL; AK010206; BAC25286.1; -; mRNA.
DR EMBL; BC024504; AAH24504.1; -; mRNA.
DR EMBL; BC024532; AAH24532.1; -; mRNA.
DR EMBL; BC024542; AAH24542.1; -; mRNA.
DR EMBL; BC024636; AAH24636.1; -; mRNA.
DR EMBL; BC034193; AAH34193.1; -; mRNA.
DR EMBL; U72677; AAB51037.1; -; mRNA.
DR CCDS; CCDS36802.1; -.
DR RefSeq; NP_666162.1; NM_146050.2.
DR RefSeq; XP_006518013.1; XM_006517950.3.
DR RefSeq; XP_006518014.1; XM_006517951.3.
DR RefSeq; XP_006518015.1; XM_006517952.2.
DR RefSeq; XP_006518016.1; XM_006517953.3.
DR RefSeq; XP_006518017.1; XM_006517954.2.
DR RefSeq; XP_011243038.1; XM_011244736.1.
DR AlphaFoldDB; P97805; -.
DR SMR; P97805; -.
DR STRING; 10090.ENSMUSP00000022269; -.
DR GlyGen; P97805; 1 site.
DR PhosphoSitePlus; P97805; -.
DR MaxQB; P97805; -.
DR PaxDb; P97805; -.
DR PeptideAtlas; P97805; -.
DR PRIDE; P97805; -.
DR ProteomicsDB; 277037; -.
DR Antibodypedia; 31681; 179 antibodies from 28 providers.
DR DNASU; 18300; -.
DR Ensembl; ENSMUST00000022269; ENSMUSP00000022269; ENSMUSG00000021749.
DR GeneID; 18300; -.
DR KEGG; mmu:18300; -.
DR UCSC; uc007sfd.1; mouse.
DR CTD; 131177; -.
DR MGI; MGI:1201784; Fam3d.
DR VEuPathDB; HostDB:ENSMUSG00000021749; -.
DR eggNOG; ENOG502RCCI; Eukaryota.
DR GeneTree; ENSGT00950000183004; -.
DR HOGENOM; CLU_099478_0_1_1; -.
DR InParanoid; P97805; -.
DR OMA; FEDHMIM; -.
DR OrthoDB; 1295040at2759; -.
DR PhylomeDB; P97805; -.
DR TreeFam; TF353414; -.
DR BioGRID-ORCS; 18300; 1 hit in 73 CRISPR screens.
DR ChiTaRS; Oit1; mouse.
DR PRO; PR:P97805; -.
DR Proteomes; UP000000589; Chromosome 14.
DR RNAct; P97805; protein.
DR Bgee; ENSMUSG00000021749; Expressed in left colon and 65 other tissues.
DR ExpressionAtlas; P97805; baseline and differential.
DR Genevisible; P97805; MM.
DR GO; GO:0005615; C:extracellular space; IDA:MGI.
DR GO; GO:0070093; P:negative regulation of glucagon secretion; IEA:InterPro.
DR GO; GO:0046676; P:negative regulation of insulin secretion; ISS:UniProtKB.
DR CDD; cd13940; ILEI_FAM3C; 1.
DR InterPro; IPR039220; FAM3.
DR InterPro; IPR039240; FAM3D.
DR InterPro; IPR039477; ILEI/PANDER_dom.
DR InterPro; IPR039475; ILEI_FAM3C.
DR PANTHER; PTHR14592; PTHR14592; 1.
DR PANTHER; PTHR14592:SF9; PTHR14592:SF9; 1.
DR Pfam; PF15711; ILEI; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT CHAIN 26..223
FT /note="Protein FAM3D"
FT /id="PRO_0000008755"
FT CARBOHYD 106
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 54..82
FT /evidence="ECO:0000250"
FT DISULFID 60..217
FT /evidence="ECO:0000250"
SQ SEQUENCE 223 AA; 24988 MW; 187ACD836D50845D CRC64;
MRVAGLIRVV VFIFTIVTMW VFLRSYTSFS RKTIRLPRWL GITPKDIQTP KSKCGLSKIC
PNNFFAFKIS SGAANVVGPS MCFEDEIIMS PVRNNVGRGL NVALVNGSTG QVMKKDSFDM
YSGDPQLLLN FLTEIPDSTL VLVASYDDPG TKMNDKIKTL FSNLGSSYAK QLGFRDSWVF
VGAKDLKSKS PYEQFLKNNP ETNKYDGWPE LLELEGCVPR KVM
