ID   FAM50_CAEEL             Reviewed;         326 AA.
AC   Q18691; D5MCS3; D5MCS4; D5MCS5;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 3.
DT   03-AUG-2022, entry version 121.
DE   RecName: Full=Protein FAM50 homolog;
GN   ORFNames=C47E8.4;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   DISRUPTION PHENOTYPE.
RX   PubMed=11137018; DOI=10.1016/s0960-9822(00)00869-1;
RA   Piano F., Schetter A.J., Mangone M., Stein L., Kemphues K.J.;
RT   "RNAi analysis of genes expressed in the ovary of Caenorhabditis elegans.";
RL   Curr. Biol. 10:1619-1622(2000).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=a;
CC         IsoId=Q18691-1; Sequence=Displayed;
CC       Name=b;
CC         IsoId=Q18691-2; Sequence=VSP_039797;
CC       Name=c;
CC         IsoId=Q18691-3; Sequence=VSP_039798;
CC   -!- DISRUPTION PHENOTYPE: Reduced growth and mobility. Larval lethal.
CC       {ECO:0000269|PubMed:11137018}.
CC   -!- SIMILARITY: Belongs to the FAM50 family. {ECO:0000305}.
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DR   EMBL; Z75530; CBL43418.1; -; Genomic_DNA.
DR   EMBL; Z75530; CBL43419.1; -; Genomic_DNA.
DR   EMBL; Z75530; CBL43420.1; -; Genomic_DNA.
DR   PIR; T20021; T20021.
DR   RefSeq; NP_001256609.1; NM_001269680.1. [Q18691-1]
DR   RefSeq; NP_001256610.1; NM_001269681.1. [Q18691-2]
DR   RefSeq; NP_001256611.1; NM_001269682.1. [Q18691-3]
DR   AlphaFoldDB; Q18691; -.
DR   SMR; Q18691; -.
DR   BioGRID; 44972; 1.
DR   DIP; DIP-27106N; -.
DR   IntAct; Q18691; 1.
DR   STRING; 6239.C47E8.4a.2; -.
DR   EPD; Q18691; -.
DR   PaxDb; Q18691; -.
DR   PeptideAtlas; Q18691; -.
DR   EnsemblMetazoa; C47E8.4a.1; C47E8.4a.1; WBGene00008143. [Q18691-1]
DR   EnsemblMetazoa; C47E8.4b.1; C47E8.4b.1; WBGene00008143. [Q18691-2]
DR   EnsemblMetazoa; C47E8.4c.1; C47E8.4c.1; WBGene00008143. [Q18691-3]
DR   GeneID; 179970; -.
DR   KEGG; cel:CELE_C47E8.4; -.
DR   UCSC; C47E8.4; c. elegans. [Q18691-1]
DR   CTD; 179970; -.
DR   WormBase; C47E8.4a; CE44805; WBGene00008143; -. [Q18691-1]
DR   WormBase; C47E8.4b; CE44798; WBGene00008143; -. [Q18691-2]
DR   WormBase; C47E8.4c; CE44813; WBGene00008143; -. [Q18691-3]
DR   eggNOG; KOG2894; Eukaryota.
DR   GeneTree; ENSGT00390000004735; -.
DR   HOGENOM; CLU_037985_1_0_1; -.
DR   InParanoid; Q18691; -.
DR   OMA; DFIWVFL; -.
DR   OrthoDB; 1061864at2759; -.
DR   PhylomeDB; Q18691; -.
DR   PRO; PR:Q18691; -.
DR   Proteomes; UP000001940; Chromosome V.
DR   Bgee; WBGene00008143; Expressed in germ line (C elegans) and 4 other tissues.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0006325; P:chromatin organization; IBA:GO_Central.
DR   InterPro; IPR007005; XAP5.
DR   PANTHER; PTHR12722; PTHR12722; 1.
DR   Pfam; PF04921; XAP5; 1.
PE   3: Inferred from homology;
KW   Alternative splicing; Reference proteome.
FT   CHAIN           1..326
FT                   /note="Protein FAM50 homolog"
FT                   /id="PRO_0000326514"
FT   REGION          77..111
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        77..96
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        97..111
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         1..232
FT                   /note="Missing (in isoform c)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_039798"
FT   VAR_SEQ         1..140
FT                   /note="Missing (in isoform b)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_039797"
SQ   SEQUENCE   326 AA;  37905 MW;  92AD59E31C0EFE00 CRC64;
     MSRADEGRLI HLAKKREREK EDIEQQLRKL EEDKEKCRVG ITNKFMANYE TVEEVVKSKT
     YGLVSLDDMK NIQKNEISNR DLQVARGDQS SSTQSKDSQE AREKEEHVAK HTQKRFLSFA
     FDDEEDEEDA APIIPKKRVG MDPTVDTSFL PDKEREEFLR KKKESLAAEW RVKQDAEKNE
     EITVAYAYWD GSSHRKNMKI KKGNTISQCL GRAIEALKKE FTELKSCTAE NLMFVKEDLI
     IPHFYTFQDF IVTKAMGKTG PLFVFDSASD VRIRQDAALD YGESHPAKIV LRSWYEKNKH
     IYPASRWEPF VPSKKYGRNF DDLSDL