FAM74_HUMAN
ID FAM74_HUMAN Reviewed; 123 AA.
AC Q5TZK3; A6NH89; Q6ZSU6;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 1.
DT 25-MAY-2022, entry version 78.
DE RecName: Full=Protein FAM74A4/A6 {ECO:0000305};
GN Name=FAM74A4 {ECO:0000312|HGNC:HGNC:32032};
GN Synonyms=FAM74A2 {ECO:0000312|HGNC:HGNC:32032};
GN and
GN Name=FAM74A6 {ECO:0000312|HGNC:HGNC:34036};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Caudate nucleus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
CC -!- INTERACTION:
CC Q5TZK3; Q15834: CCDC85B; NbExp=3; IntAct=EBI-10247271, EBI-739674;
CC Q5TZK3; O95273: CCNDBP1; NbExp=3; IntAct=EBI-10247271, EBI-748961;
CC Q5TZK3; Q9C0F1: CEP44; NbExp=3; IntAct=EBI-10247271, EBI-744115;
CC Q5TZK3; O95967: EFEMP2; NbExp=3; IntAct=EBI-10247271, EBI-743414;
CC Q5TZK3; Q92979: EMG1; NbExp=3; IntAct=EBI-10247271, EBI-718638;
CC Q5TZK3; P28799: GRN; NbExp=3; IntAct=EBI-10247271, EBI-747754;
CC Q5TZK3; Q6NT76: HMBOX1; NbExp=3; IntAct=EBI-10247271, EBI-2549423;
CC Q5TZK3; Q13422: IKZF1; NbExp=3; IntAct=EBI-10247271, EBI-745305;
CC Q5TZK3; Q15323: KRT31; NbExp=3; IntAct=EBI-10247271, EBI-948001;
CC Q5TZK3; Q6A162: KRT40; NbExp=3; IntAct=EBI-10247271, EBI-10171697;
CC Q5TZK3; P60370: KRTAP10-5; NbExp=3; IntAct=EBI-10247271, EBI-10172150;
CC Q5TZK3; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-10247271, EBI-10172290;
CC Q5TZK3; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-10247271, EBI-10171774;
CC Q5TZK3; P60411: KRTAP10-9; NbExp=3; IntAct=EBI-10247271, EBI-10172052;
CC Q5TZK3; Q9BYR5: KRTAP4-2; NbExp=3; IntAct=EBI-10247271, EBI-10172511;
CC Q5TZK3; P26371: KRTAP5-9; NbExp=3; IntAct=EBI-10247271, EBI-3958099;
CC Q5TZK3; Q9BRK4: LZTS2; NbExp=3; IntAct=EBI-10247271, EBI-741037;
CC Q5TZK3; P50222: MEOX2; NbExp=3; IntAct=EBI-10247271, EBI-748397;
CC Q5TZK3; Q5JR59: MTUS2; NbExp=3; IntAct=EBI-10247271, EBI-742948;
CC Q5TZK3; Q7Z3S9: NOTCH2NLA; NbExp=3; IntAct=EBI-10247271, EBI-945833;
CC Q5TZK3; Q5VU43: PDE4DIP; NbExp=3; IntAct=EBI-10247271, EBI-1105124;
CC Q5TZK3; Q8IXK0: PHC2; NbExp=3; IntAct=EBI-10247271, EBI-713786;
CC Q5TZK3; Q96KN7: RPGRIP1; NbExp=3; IntAct=EBI-10247271, EBI-1050213;
CC Q5TZK3; O75558: STX11; NbExp=3; IntAct=EBI-10247271, EBI-714135;
CC Q5TZK3; P15884: TCF4; NbExp=3; IntAct=EBI-10247271, EBI-533224;
CC Q5TZK3; O76024: WFS1; NbExp=3; IntAct=EBI-10247271, EBI-720609;
CC -!- SIMILARITY: Belongs to the FAM74 family. {ECO:0000305}.
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DR EMBL; AK127145; BAC86850.1; -; mRNA.
DR EMBL; AL590491; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX005040; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; Q5TZK3; -.
DR IntAct; Q5TZK3; 26.
DR iPTMnet; Q5TZK3; -.
DR PhosphoSitePlus; Q5TZK3; -.
DR BioMuta; HGNC:32032; -.
DR PRIDE; Q5TZK3; -.
DR GeneCards; FAM74A4; -.
DR GeneCards; FAM74A6; -.
DR HGNC; HGNC:32032; FAM74A4.
DR HGNC; HGNC:34036; FAM74A6.
DR neXtProt; NX_Q5TZK3; -.
DR InParanoid; Q5TZK3; -.
DR PhylomeDB; Q5TZK3; -.
DR PathwayCommons; Q5TZK3; -.
DR SignaLink; Q5TZK3; -.
DR Pharos; Q5TZK3; Tdark.
DR PRO; PR:Q5TZK3; -.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; Q5TZK3; protein.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..123
FT /note="Protein FAM74A4/A6"
FT /id="PRO_0000266047"
FT REGION 1..64
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 17..64
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 13
FT /note="V -> L (in Ref. 1; BAC86850)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 123 AA; 14773 MW; 1DAC8479980565FF CRC64;
MWRELRGCPG GDVETAQRLS QRRRGKSSEA VPEKTWRAQR MSQRRRGESS EAVPEKTWKE
LRNSETVPEK TWKQLRGCLQ EDVQRVQRLS RRRHGESSKA VHKKMWREFR GCRYCCTWLF
FFG
