ID   FAM91_DICDI             Reviewed;         930 AA.
AC   Q8T158; Q555N9;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 2.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Protein FAM91 homolog;
GN   Name=fam91; ORFNames=DDB_G0274247;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [3]
RP   DISRUPTION PHENOTYPE.
RX   PubMed=16507593; DOI=10.1242/jcs.02819;
RA   Torija P., Vicente J.J., Rodrigues T.B., Robles A., Cerdan S., Sastre L.,
RA   Calvo R.M., Escalante R.;
RT   "Functional genomics in Dictyostelium: midA, a new conserved protein, is
RT   required for mitochondrial function and development.";
RL   J. Cell Sci. 119:1154-1164(2006).
CC   -!- DISRUPTION PHENOTYPE: No visible phenotype.
CC       {ECO:0000269|PubMed:16507593}.
CC   -!- SIMILARITY: Belongs to the FAM91 family. {ECO:0000305}.
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DR   EMBL; AAFI02000012; EAL70016.1; -; Genomic_DNA.
DR   RefSeq; XP_644026.1; XM_638934.1.
DR   AlphaFoldDB; Q8T158; -.
DR   SMR; Q8T158; -.
DR   STRING; 44689.DDB0232150; -.
DR   PaxDb; Q8T158; -.
DR   EnsemblProtists; EAL70016; EAL70016; DDB_G0274247.
DR   GeneID; 8619456; -.
DR   KEGG; ddi:DDB_G0274247; -.
DR   dictyBase; DDB_G0274247; fam91.
DR   eggNOG; KOG3707; Eukaryota.
DR   HOGENOM; CLU_010656_0_0_1; -.
DR   InParanoid; Q8T158; -.
DR   OMA; PEHGPAN; -.
DR   PhylomeDB; Q8T158; -.
DR   Reactome; R-DDI-9013407; RHOH GTPase cycle.
DR   PRO; PR:Q8T158; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   InterPro; IPR039199; FAM91.
DR   InterPro; IPR028097; FAM91_C_dom.
DR   InterPro; IPR028091; FAM91_N_dom.
DR   PANTHER; PTHR28441; PTHR28441; 1.
DR   Pfam; PF14648; FAM91_C; 1.
DR   Pfam; PF14647; FAM91_N; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..930
FT                   /note="Protein FAM91 homolog"
FT                   /id="PRO_0000327470"
FT   REGION          349..397
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          780..823
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   930 AA;  105878 MW;  75FBC21A75881EBA CRC64;
     MDQSSEKELE KYINNRVQWD SLPSHAKSIL DQSHVKYKQY CLKYSIKHQL RWDTNLISSF
     VTDERLYYQE IVRLSVANLV LYPYHIQDKL VPMLNVTPFK YYLIMMIETM TNSKSYDEIP
     NFTAVDCIRV LGIGRNQFID LMNKFRSKGF LFKKKKDVIR GLLPTRSLEK NIEYWWILRY
     GYPNQDEERQ GSLPASELEV LDDLKRSNGI NGKQAGIYCR ESVISLISKG LVYIDVPIQN
     QDTISVPPLE GFVMNRVLGD YFENLLYKIF VSIDERTTIQ KLSEVLQINV ELVKQACSLY
     CRLGFAKKKN LEPLLPQTPS PSSEGDTHSK WHHSWITYYQ ENETIIPQPI LNNNNNNSNT
     IDNSNNNNNN NTNITSSSSS NTAINNSSQS STLENNDNIV EGVVDESFNN GNEEQKRIGF
     VFDSSITAFL MMGNLGYGLK NHAVTMFERG KLSNEALADF LQELDKIDVE EFVDSEAKLY
     ATNAISLRDT IRHLKNKYRI DDSNSSNSNS SSGGGSGNLQ GLDLISCERM NQLDETTRIR
     VLKKNYSVLI SMAPLSIDYC PVISSVPPNF GPAVYEVHSF WFRIYLYSMV GKGPNSILLP
     KGTRLKRIPT IFKDCEKILV CPIDHDPTTV NLSQLLPSVN ETLLSSPVLL SAYTFIKYDT
     QPKLSKLMSH SRSNSIVSSS KDNQLLYHIP FPLDDLSADN GSPKKYTNII TNNTTTTTTT
     TTTTNTTNLN NNTIISEDQY NSDNIHTHPI LYKIQSTFNL KNSFGYITLL KKETHILLNN
     NNNNNNKNNI NNNKNNNNNN NNNNNNNNNN NNNNNNNNNN NNSITHQKVF EYLPLNVYYG
     IPIFDDKLNR EVCAKIDKFN LLSKENLNRH SMDSRNLSLN LFNFISSTCP PIHPDLDSID
     ATKINSNLPS VQNIPFPTQI ITFVNGNLDL