FAM9A_HUMAN
ID FAM9A_HUMAN Reviewed; 332 AA.
AC Q8IZU1; B7ZLH5; Q2M2D1;
DT 25-MAR-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Protein FAM9A;
GN Name=FAM9A;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND SUBCELLULAR LOCATION.
RX PubMed=12213195; DOI=10.1006/geno.2002.6834;
RA Martinez-Garay I., Jablonka S., Sutajova M., Steuernagel P., Gal A.,
RA Kutsche K.;
RT "A new gene family (FAM9) of low-copy repeats in Xp22.3 expressed
RT exclusively in testis: implications for recombinations in this region.";
RL Genomics 80:259-267(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q8IZU1; O15145: ARPC3; NbExp=3; IntAct=EBI-8468186, EBI-351829;
CC Q8IZU1; P55212: CASP6; NbExp=3; IntAct=EBI-8468186, EBI-718729;
CC Q8IZU1; P28329-3: CHAT; NbExp=3; IntAct=EBI-8468186, EBI-25837549;
CC Q8IZU1; Q9UI47-2: CTNNA3; NbExp=3; IntAct=EBI-8468186, EBI-11962928;
CC Q8IZU1; P99999: CYCS; NbExp=3; IntAct=EBI-8468186, EBI-446479;
CC Q8IZU1; G5E9A7: DMWD; NbExp=3; IntAct=EBI-8468186, EBI-10976677;
CC Q8IZU1; Q01658: DR1; NbExp=3; IntAct=EBI-8468186, EBI-750300;
CC Q8IZU1; P11474: ESRRA; NbExp=3; IntAct=EBI-8468186, EBI-372412;
CC Q8IZU1; P62508-3: ESRRG; NbExp=3; IntAct=EBI-8468186, EBI-12001340;
CC Q8IZU1; Q8IZU0: FAM9B; NbExp=5; IntAct=EBI-8468186, EBI-10175124;
CC Q8IZU1; P22607: FGFR3; NbExp=3; IntAct=EBI-8468186, EBI-348399;
CC Q8IZU1; Q53GS7: GLE1; NbExp=3; IntAct=EBI-8468186, EBI-1955541;
CC Q8IZU1; P28799: GRN; NbExp=3; IntAct=EBI-8468186, EBI-747754;
CC Q8IZU1; Q00403: GTF2B; NbExp=3; IntAct=EBI-8468186, EBI-389564;
CC Q8IZU1; U3KQK0: H2BC15; NbExp=3; IntAct=EBI-8468186, EBI-12142839;
CC Q8IZU1; A0A024R4Z4: hCG_2042749; NbExp=3; IntAct=EBI-8468186, EBI-14231181;
CC Q8IZU1; O00291: HIP1; NbExp=3; IntAct=EBI-8468186, EBI-473886;
CC Q8IZU1; Q86YM7: HOMER1; NbExp=3; IntAct=EBI-8468186, EBI-746815;
CC Q8IZU1; P01112: HRAS; NbExp=3; IntAct=EBI-8468186, EBI-350145;
CC Q8IZU1; P04792: HSPB1; NbExp=3; IntAct=EBI-8468186, EBI-352682;
CC Q8IZU1; P42858: HTT; NbExp=18; IntAct=EBI-8468186, EBI-466029;
CC Q8IZU1; Q96CB8: INTS12; NbExp=3; IntAct=EBI-8468186, EBI-1049156;
CC Q8IZU1; O60341: KDM1A; NbExp=2; IntAct=EBI-8468186, EBI-710124;
CC Q8IZU1; O60333-2: KIF1B; NbExp=3; IntAct=EBI-8468186, EBI-10975473;
CC Q8IZU1; P13473-2: LAMP2; NbExp=3; IntAct=EBI-8468186, EBI-21591415;
CC Q8IZU1; Q5T753: LCE1E; NbExp=3; IntAct=EBI-8468186, EBI-11955335;
CC Q8IZU1; P02545: LMNA; NbExp=3; IntAct=EBI-8468186, EBI-351935;
CC Q8IZU1; Q96EZ8: MCRS1; NbExp=3; IntAct=EBI-8468186, EBI-348259;
CC Q8IZU1; P42568: MLLT3; NbExp=4; IntAct=EBI-8468186, EBI-716132;
CC Q8IZU1; Q15742: NAB2; NbExp=3; IntAct=EBI-8468186, EBI-8641936;
CC Q8IZU1; P49821: NDUFV1; NbExp=3; IntAct=EBI-8468186, EBI-748312;
CC Q8IZU1; P07196: NEFL; NbExp=3; IntAct=EBI-8468186, EBI-475646;
CC Q8IZU1; P35240: NF2; NbExp=3; IntAct=EBI-8468186, EBI-1014472;
CC Q8IZU1; P35240-4: NF2; NbExp=3; IntAct=EBI-8468186, EBI-1014514;
CC Q8IZU1; Q9UBU9: NXF1; NbExp=3; IntAct=EBI-8468186, EBI-398874;
CC Q8IZU1; P78364: PHC1; NbExp=3; IntAct=EBI-8468186, EBI-725403;
CC Q8IZU1; Q9NRD5: PICK1; NbExp=3; IntAct=EBI-8468186, EBI-79165;
CC Q8IZU1; Q99873: PRMT1; NbExp=2; IntAct=EBI-8468186, EBI-78738;
CC Q8IZU1; O75400-2: PRPF40A; NbExp=3; IntAct=EBI-8468186, EBI-5280197;
CC Q8IZU1; P86480: PRR20D; NbExp=3; IntAct=EBI-8468186, EBI-12754095;
CC Q8IZU1; P62826: RAN; NbExp=3; IntAct=EBI-8468186, EBI-286642;
CC Q8IZU1; Q2KHN1: RNF151; NbExp=3; IntAct=EBI-8468186, EBI-12002474;
CC Q8IZU1; P78317: RNF4; NbExp=3; IntAct=EBI-8468186, EBI-2340927;
CC Q8IZU1; Q06455-2: RUNX1T1; NbExp=3; IntAct=EBI-8468186, EBI-11984663;
CC Q8IZU1; O00560: SDCBP; NbExp=3; IntAct=EBI-8468186, EBI-727004;
CC Q8IZU1; Q9Y371: SH3GLB1; NbExp=3; IntAct=EBI-8468186, EBI-2623095;
CC Q8IZU1; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-8468186, EBI-5235340;
CC Q8IZU1; Q96MF2: STAC3; NbExp=3; IntAct=EBI-8468186, EBI-745680;
CC Q8IZU1; P31948: STIP1; NbExp=3; IntAct=EBI-8468186, EBI-1054052;
CC Q8IZU1; Q13148: TARDBP; NbExp=6; IntAct=EBI-8468186, EBI-372899;
CC Q8IZU1; Q9NVV9: THAP1; NbExp=3; IntAct=EBI-8468186, EBI-741515;
CC Q8IZU1; Q12933: TRAF2; NbExp=3; IntAct=EBI-8468186, EBI-355744;
CC Q8IZU1; O00463: TRAF5; NbExp=3; IntAct=EBI-8468186, EBI-523498;
CC Q8IZU1; Q8WV44: TRIM41; NbExp=3; IntAct=EBI-8468186, EBI-725997;
CC Q8IZU1; P40222: TXLNA; NbExp=3; IntAct=EBI-8468186, EBI-359793;
CC Q8IZU1; O76024: WFS1; NbExp=3; IntAct=EBI-8468186, EBI-720609;
CC Q8IZU1; Q15916: ZBTB6; NbExp=3; IntAct=EBI-8468186, EBI-7227791;
CC Q8IZU1; Q96BV0: ZNF775; NbExp=3; IntAct=EBI-8468186, EBI-7149881;
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12213195}.
CC -!- TISSUE SPECIFICITY: Expressed exclusively in testis.
CC {ECO:0000269|PubMed:12213195}.
CC -!- SIMILARITY: Belongs to the FAM9 family. {ECO:0000305}.
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DR EMBL; AF494343; AAN07162.1; -; mRNA.
DR EMBL; BC112022; AAI12023.1; -; mRNA.
DR EMBL; BC113449; AAI13450.1; -; mRNA.
DR EMBL; BC143805; AAI43806.1; -; mRNA.
DR CCDS; CCDS14131.1; -.
DR RefSeq; NP_001164657.1; NM_001171186.1.
DR RefSeq; NP_777611.1; NM_174951.3.
DR AlphaFoldDB; Q8IZU1; -.
DR BioGRID; 128130; 83.
DR IntAct; Q8IZU1; 73.
DR MINT; Q8IZU1; -.
DR STRING; 9606.ENSP00000440163; -.
DR BioMuta; FAM9A; -.
DR DMDM; 29336759; -.
DR MassIVE; Q8IZU1; -.
DR PaxDb; Q8IZU1; -.
DR PeptideAtlas; Q8IZU1; -.
DR PRIDE; Q8IZU1; -.
DR Antibodypedia; 52846; 6 antibodies from 6 providers.
DR DNASU; 171482; -.
DR Ensembl; ENST00000381003.7; ENSP00000370391.3; ENSG00000183304.10.
DR Ensembl; ENST00000543214.1; ENSP00000440163.1; ENSG00000183304.10.
DR GeneID; 171482; -.
DR KEGG; hsa:171482; -.
DR MANE-Select; ENST00000381003.7; ENSP00000370391.3; NM_174951.3; NP_777611.1.
DR UCSC; uc004csg.4; human.
DR CTD; 171482; -.
DR DisGeNET; 171482; -.
DR GeneCards; FAM9A; -.
DR HGNC; HGNC:18403; FAM9A.
DR HPA; ENSG00000183304; Tissue enriched (testis).
DR MIM; 300477; gene.
DR neXtProt; NX_Q8IZU1; -.
DR OpenTargets; ENSG00000183304; -.
DR PharmGKB; PA27992; -.
DR VEuPathDB; HostDB:ENSG00000183304; -.
DR eggNOG; ENOG502TEZS; Eukaryota.
DR GeneTree; ENSGT00390000000062; -.
DR HOGENOM; CLU_083208_0_0_1; -.
DR InParanoid; Q8IZU1; -.
DR OMA; MKLEYIA; -.
DR OrthoDB; 1187915at2759; -.
DR PhylomeDB; Q8IZU1; -.
DR PathwayCommons; Q8IZU1; -.
DR SignaLink; Q8IZU1; -.
DR BioGRID-ORCS; 171482; 15 hits in 697 CRISPR screens.
DR GenomeRNAi; 171482; -.
DR Pharos; Q8IZU1; Tdark.
DR PRO; PR:Q8IZU1; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q8IZU1; protein.
DR Bgee; ENSG00000183304; Expressed in right testis and 10 other tissues.
DR Genevisible; Q8IZU1; HS.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0000795; C:synaptonemal complex; IBA:GO_Central.
DR GO; GO:0051321; P:meiotic cell cycle; IBA:GO_Central.
DR GO; GO:0007286; P:spermatid development; IBA:GO_Central.
PE 1: Evidence at protein level;
KW Nucleus; Reference proteome.
FT CHAIN 1..332
FT /note="Protein FAM9A"
FT /id="PRO_0000119032"
FT REGION 1..114
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 186..293
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..39
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 68..114
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 217..276
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 332 AA; 37339 MW; 92F22EC36038229C CRC64;
MEPVGRKRSR KAAKAQLEAQ VTAAQGATKE GSGIASNFPG QPTMEPVGRK RSRKAAKAQL
EAQVRAAPAK KHTGKDPVRD ECEERNPFTE TREEDVTDEH GEREPFAEKD EHTGIHTMKL
EHIAADIKKG LAAKREMIKI DKAAYRKTKN TIERALKKKQ LKRQKRDYRH TRKLLNVLKE
YIAEKQKDDE AEEAEAAAAA AEAAAAAEAA AAAAEVIVVE DEEEEEKEEE EEKEEEEEEG
EEEGGGEEGE EGGGGGEGEE TEEEEEEEEE EEEEEQIKAF QEKQKRWQQP TGVRSWRLRE
MKPLLEQLLK AAKDTKDNYC IISSSEESEL DN
