FAM9C_HUMAN
ID FAM9C_HUMAN Reviewed; 166 AA.
AC Q8IZT9; B2R9G7; Q5HYJ6;
DT 25-MAR-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Protein FAM9C;
GN Name=FAM9C;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND SUBCELLULAR LOCATION.
RX PubMed=12213195; DOI=10.1006/geno.2002.6834;
RA Martinez-Garay I., Jablonka S., Sutajova M., Steuernagel P., Gal A.,
RA Kutsche K.;
RT "A new gene family (FAM9) of low-copy repeats in Xp22.3 expressed
RT exclusively in testis: implications for recombinations in this region.";
RL Genomics 80:259-267(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Heart;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q8IZT9; Q9NYB9-2: ABI2; NbExp=3; IntAct=EBI-2870039, EBI-11096309;
CC Q8IZT9; Q96GS4: BORCS6; NbExp=3; IntAct=EBI-2870039, EBI-10193358;
CC Q8IZT9; O14777: NDC80; NbExp=3; IntAct=EBI-2870039, EBI-715849;
CC Q8IZT9; Q96BD8: SKA1; NbExp=3; IntAct=EBI-2870039, EBI-741854;
CC Q8IZT9; O95721: SNAP29; NbExp=3; IntAct=EBI-2870039, EBI-490676;
CC Q8IZT9; O75971-2: SNAPC5; NbExp=3; IntAct=EBI-2870039, EBI-12004298;
CC Q8IZT9; Q9BXU0: TEX12; NbExp=3; IntAct=EBI-2870039, EBI-12090309;
CC Q8IZT9; P09493-10: TPM1; NbExp=3; IntAct=EBI-2870039, EBI-12123928;
CC Q8IZT9; P06753: TPM3; NbExp=8; IntAct=EBI-2870039, EBI-355607;
CC Q8IZT9; Q5VU62: TPM3; NbExp=3; IntAct=EBI-2870039, EBI-10184033;
CC Q8IZT9; Q8N7C3: TRIML2; NbExp=3; IntAct=EBI-2870039, EBI-11059915;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12213195}.
CC -!- TISSUE SPECIFICITY: Expressed exclusively in testis.
CC {ECO:0000269|PubMed:12213195}.
CC -!- SIMILARITY: Belongs to the FAM9 family. {ECO:0000305}.
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DR EMBL; AF494345; AAN07164.1; -; mRNA.
DR EMBL; AK313776; BAG36514.1; -; mRNA.
DR EMBL; BX647580; CAI46094.1; -; mRNA.
DR EMBL; BC127957; AAI27958.1; -; mRNA.
DR CCDS; CCDS35203.1; -.
DR RefSeq; NP_777561.1; NM_174901.5.
DR RefSeq; XP_005274517.1; XM_005274460.2.
DR RefSeq; XP_016884810.1; XM_017029321.1.
DR AlphaFoldDB; Q8IZT9; -.
DR SMR; Q8IZT9; -.
DR BioGRID; 128132; 61.
DR IntAct; Q8IZT9; 12.
DR STRING; 9606.ENSP00000334430; -.
DR BioMuta; FAM9C; -.
DR DMDM; 29336757; -.
DR EPD; Q8IZT9; -.
DR MassIVE; Q8IZT9; -.
DR PaxDb; Q8IZT9; -.
DR PeptideAtlas; Q8IZT9; -.
DR PRIDE; Q8IZT9; -.
DR ProteomicsDB; 71427; -.
DR TopDownProteomics; Q8IZT9; -.
DR Antibodypedia; 23822; 10 antibodies from 6 providers.
DR DNASU; 171484; -.
DR Ensembl; ENST00000333995.7; ENSP00000334430.3; ENSG00000187268.12.
DR Ensembl; ENST00000380625.8; ENSP00000369999.3; ENSG00000187268.12.
DR GeneID; 171484; -.
DR KEGG; hsa:171484; -.
DR MANE-Select; ENST00000380625.8; ENSP00000369999.3; NM_174901.6; NP_777561.1.
DR UCSC; uc004cvg.4; human.
DR CTD; 171484; -.
DR DisGeNET; 171484; -.
DR GeneCards; FAM9C; -.
DR HGNC; HGNC:18405; FAM9C.
DR HPA; ENSG00000187268; Tissue enriched (lymphoid).
DR MIM; 300479; gene.
DR neXtProt; NX_Q8IZT9; -.
DR OpenTargets; ENSG00000187268; -.
DR PharmGKB; PA27994; -.
DR VEuPathDB; HostDB:ENSG00000187268; -.
DR eggNOG; ENOG502R11H; Eukaryota.
DR GeneTree; ENSGT00390000000062; -.
DR HOGENOM; CLU_083208_2_0_1; -.
DR InParanoid; Q8IZT9; -.
DR OMA; GNICIFI; -.
DR OrthoDB; 1187915at2759; -.
DR PhylomeDB; Q8IZT9; -.
DR TreeFam; TF328876; -.
DR PathwayCommons; Q8IZT9; -.
DR SignaLink; Q8IZT9; -.
DR BioGRID-ORCS; 171484; 10 hits in 684 CRISPR screens.
DR GenomeRNAi; 171484; -.
DR Pharos; Q8IZT9; Tdark.
DR PRO; PR:Q8IZT9; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q8IZT9; protein.
DR Bgee; ENSG00000187268; Expressed in apex of heart and 72 other tissues.
DR ExpressionAtlas; Q8IZT9; baseline and differential.
DR Genevisible; Q8IZT9; HS.
DR GO; GO:0000795; C:synaptonemal complex; IBA:GO_Central.
DR GO; GO:0051321; P:meiotic cell cycle; IBA:GO_Central.
DR GO; GO:0007286; P:spermatid development; IBA:GO_Central.
DR InterPro; IPR006888; XLR/SYCP3/FAM9_dom.
DR Pfam; PF04803; Cor1; 1.
PE 1: Evidence at protein level;
KW Nucleus; Reference proteome.
FT CHAIN 1..166
FT /note="Protein FAM9C"
FT /id="PRO_0000119034"
FT REGION 17..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 129..166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..63
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 166 AA; 19210 MW; 247460DA7E86FB66 CRC64;
MAAKDQLEVQ VMAAQEMELA GKDPVSHEHE ERKPVTETKE GDVTDEHGER GSFAETDEHT
GVDTKELEDI AADIKEHLAA KRKRIEKIAK ACSEIKNRIK NVLRTTQLKR QKRDYRISLK
LPNVLEEFIT DEQKDEEGDG EKEEQIKIFQ EQQKRWQQDG KGTERD
