ID   FANCB_MOUSE             Reviewed;         703 AA.
AC   Q5XJY6;
DT   25-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2005, sequence version 2.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Fanconi anemia group B protein homolog;
DE            Short=Protein FACB;
GN   Name=Fancb;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Embryonic germ cell;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: DNA repair protein required for FANCD2 ubiquitination.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Belongs to the multisubunit FA complex composed of FANCA,
CC       FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and FANCM. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH83151.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BC083151; AAH83151.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001139553.1; NM_001146081.1.
DR   RefSeq; NP_778192.3; NM_175027.4.
DR   AlphaFoldDB; Q5XJY6; -.
DR   SMR; Q5XJY6; -.
DR   BioGRID; 231849; 1.
DR   iPTMnet; Q5XJY6; -.
DR   PhosphoSitePlus; Q5XJY6; -.
DR   MaxQB; Q5XJY6; -.
DR   PaxDb; Q5XJY6; -.
DR   PRIDE; Q5XJY6; -.
DR   ProteomicsDB; 277039; -.
DR   DNASU; 237211; -.
DR   GeneID; 237211; -.
DR   KEGG; mmu:237211; -.
DR   CTD; 2187; -.
DR   MGI; MGI:2448558; Fancb.
DR   eggNOG; ENOG502QWED; Eukaryota.
DR   InParanoid; Q5XJY6; -.
DR   OrthoDB; 239029at2759; -.
DR   Reactome; R-MMU-6783310; Fanconi Anemia Pathway.
DR   BioGRID-ORCS; 237211; 26 hits in 110 CRISPR screens.
DR   PRO; PR:Q5XJY6; -.
DR   Proteomes; UP000000589; Unplaced.
DR   RNAct; Q5XJY6; protein.
DR   GO; GO:0000785; C:chromatin; ISO:MGI.
DR   GO; GO:0043240; C:Fanconi anaemia nuclear complex; ISS:UniProtKB.
DR   GO; GO:0072757; P:cellular response to camptothecin; IGI:MGI.
DR   GO; GO:1901655; P:cellular response to ketone; IMP:MGI.
DR   GO; GO:0071407; P:cellular response to organic cyclic compound; IMP:MGI.
DR   GO; GO:0071417; P:cellular response to organonitrogen compound; IMP:MGI.
DR   GO; GO:0071466; P:cellular response to xenobiotic stimulus; IMP:MGI.
DR   GO; GO:0036297; P:interstrand cross-link repair; IEA:InterPro.
DR   GO; GO:2000042; P:negative regulation of double-strand break repair via homologous recombination; IGI:MGI.
DR   GO; GO:1905168; P:positive regulation of double-strand break repair via homologous recombination; IGI:MGI.
DR   GO; GO:0006513; P:protein monoubiquitination; ISO:MGI.
DR   GO; GO:1990414; P:replication-born double-strand break repair via sister chromatid exchange; IMP:MGI.
DR   InterPro; IPR033333; FANCB.
DR   PANTHER; PTHR28450; PTHR28450; 2.
PE   2: Evidence at transcript level;
KW   DNA damage; DNA repair; Nucleus; Reference proteome.
FT   CHAIN           1..703
FT                   /note="Fanconi anemia group B protein homolog"
FT                   /id="PRO_0000087182"
SQ   SEQUENCE   703 AA;  80088 MW;  8160AF95C02C876B CRC64;
     MSKQSSCAIM GKSLSFSLSR GERADLEMPT DPLVLGVKRM MFDRETSTFL LISTVFLNIN
     EKDSHLKILC CNCVSDLRTR INLPCVLIQC RKYNSEAFKY CILLLHNLNR VERLLSFELN
     HALDENTKIF DGPIVFWQYL NQFFYISSAI GKVTTISLML SSIEWIGEIE NFGLGFLGLA
     EPSEDKCTQK LSESDYEFSN SSLCAYALKS QEMLSNGYLI PLAYSTMVTH VHVWAAEMVD
     HQLRTSLIAL TRKNQLILFQ NGIPVRACQL PFPGPRSVQI LDAGKRNRFF IVSFPSKACA
     VSEKKFKVVA KWEQLSLVLV NDFAGVGTEQ VLVVFEDSLD ADQLTSFTVT DFVKIWYSTK
     PLDCCEDPLA EEEHENYYLV LPALEGQLDN SFIFLNKIQQ HISFKDKFIA KSWKALLNAV
     YGKGDSLPSD EMVKLDQDGL VPFCDEGEDS VPTPEENLPD NFPEPEHIVE QTWCHVLDDD
     LVVGAKVTSL KESNEMTLSL IMNQGNRSSF HLMKCHSQVW LLKHMKCERI QECTEIYLYK
     KLRNCGALFS WEQRTASEGI LTIYCRSQGV LFQCLDHLIK VLPEICSFKY LKVENEDFLV
     DHLSSTLEAE LVTFCSVSTS AFEYVRGGYN CRIRRTDNRA MTFLGRRAKI RQSKRKVQRE
     RILKHLNMTV NGSSYAEMTL ALAEIQLKSD LIVKTLANFV IAL