ID   FANCC_BOVIN             Reviewed;         567 AA.
AC   O19104;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Fanconi anemia group C protein homolog;
DE            Short=Protein FACC;
GN   Name=FANCC; Synonyms=FACC;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Liver;
RX   PubMed=9196001; DOI=10.1007/s003359900490;
RA   Wong J.C.Y., Alon N., Buchwald M.;
RT   "Cloning of the bovine and rat Fanconi anemia group C cDNA.";
RL   Mamm. Genome 8:522-525(1997).
CC   -!- FUNCTION: DNA repair protein that may operate in a postreplication
CC       repair or a cell cycle checkpoint function. May be implicated in
CC       interstrand DNA cross-link repair and in the maintenance of normal
CC       chromosome stability. Upon IFNG induction, may facilitate STAT1
CC       activation by recruiting STAT1 to IFNGR1 (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Belongs to the multisubunit FA complex composed of FANCA,
CC       FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and FANCM. This complex
CC       may also include HSP70. Interacts with ZBTB32. Upon IFNG induction,
CC       interacts with STAT1. Interacts with CDK1. Interacts with EIF2AK2 (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC       Note=The major form is nuclear. The minor form is cytoplasmic.
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DR   EMBL; U73585; AAB66674.1; -; mRNA.
DR   RefSeq; NP_776741.1; NM_174316.2.
DR   AlphaFoldDB; O19104; -.
DR   SMR; O19104; -.
DR   STRING; 9913.ENSBTAP00000022853; -.
DR   PaxDb; O19104; -.
DR   PRIDE; O19104; -.
DR   GeneID; 281762; -.
DR   KEGG; bta:281762; -.
DR   CTD; 2176; -.
DR   eggNOG; ENOG502QSB8; Eukaryota.
DR   InParanoid; O19104; -.
DR   OrthoDB; 1546359at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0043240; C:Fanconi anaemia nuclear complex; ISS:UniProtKB.
DR   GO; GO:0034599; P:cellular response to oxidative stress; IBA:GO_Central.
DR   GO; GO:0036297; P:interstrand cross-link repair; IEA:InterPro.
DR   GO; GO:0006289; P:nucleotide-excision repair; IBA:GO_Central.
DR   InterPro; IPR000686; FANCC.
DR   PANTHER; PTHR16798; PTHR16798; 1.
DR   Pfam; PF02106; Fanconi_C; 1.
DR   PIRSF; PIRSF018417; FACC_protein; 1.
DR   PRINTS; PR00494; FANCONICGENE.
PE   2: Evidence at transcript level;
KW   Cytoplasm; DNA damage; DNA repair; Nucleus; Reference proteome.
FT   CHAIN           1..567
FT                   /note="Fanconi anemia group C protein homolog"
FT                   /id="PRO_0000087183"
SQ   SEQUENCE   567 AA;  64721 MW;  D9B2285E24A177B8 CRC64;
     MAEDSAGLPS NYQFWMQKLS VWTQASTLET QRDICLHLPQ FQEFLRRMYE TLKEMDSNAI
     IERFPTICQL LAKSCWSPFI LAYDESPKIL IWCLCCLIKK DPQNSRESKL NSWTRRLLSH
     IVSTSRFDIK EVGLFNQVLG YAPTDYYPGL LKNMVLSLVS ELRENHLNGF SSQRRCPERV
     RSLSRDRVPL LTLPDFEPLV EALLTYHGHE PQEVLCPEFF DAVNEASLLK KISLPTSAIL
     CLWLRHLPSL ENTMLHLLEK LISSERNSLR RIKCFMKDSL RPEAAACHPA IFRVVDEIFR
     SALLETDGAP EVLAGLQVFT RCFVEALEKE NKQLKFALKT YFPYASPALV MVLLQHPKDI
     PQGLWHQSLK HISEMLKEIV EDHGSYGGPF ESWFLFVHFG GWADITAEQL LMSEAEAEPP
     EALLWLLAFS CSPGAGHQQR ARTMVEVKTV LGCLTKLFRS PALSARDLQA AAGENLGGDP
     RPPACQQLVR RLLLHFLLWA PGGHTIAREV ITLMAQTDAI MNEIIGFLDY TLYRWDHLCV
     EAHRSRKLAR ELLTELREQA LPGQVNQ