FANCC_RAT
ID FANCC_RAT Reviewed; 557 AA.
AC O35870;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 25-MAY-2022, entry version 104.
DE RecName: Full=Fanconi anemia group C protein homolog;
DE Short=Protein FACC;
GN Name=Fancc; Synonyms=Facc;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Uterus;
RX PubMed=9196001; DOI=10.1007/s003359900490;
RA Wong J.C.Y., Alon N., Buchwald M.;
RT "Cloning of the bovine and rat Fanconi anemia group C cDNA.";
RL Mamm. Genome 8:522-525(1997).
CC -!- FUNCTION: DNA repair protein that may operate in a postreplication
CC repair or a cell cycle checkpoint function. May be implicated in
CC interstrand DNA cross-link repair and in the maintenance of normal
CC chromosome stability. Upon IFNG induction, may facilitate STAT1
CC activation by recruiting STAT1 to IFNGR1 (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Belongs to the multisubunit FA complex composed of FANCA,
CC FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and FANCM. This complex
CC may also include HSP70. Interacts with ZBTB32. Upon IFNG induction,
CC interacts with STAT1. Interacts with CDK1. Interacts with EIF2AK2 (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC Note=The major form is nuclear. The minor form is cytoplasmic.
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DR EMBL; U73586; AAB66675.1; -; mRNA.
DR AlphaFoldDB; O35870; -.
DR SMR; O35870; -.
DR STRING; 10116.ENSRNOP00000022884; -.
DR PaxDb; O35870; -.
DR UCSC; RGD:2593; rat.
DR RGD; 2593; Fancc.
DR eggNOG; ENOG502QSB8; Eukaryota.
DR InParanoid; O35870; -.
DR PhylomeDB; O35870; -.
DR Reactome; R-RNO-6783310; Fanconi Anemia Pathway.
DR PRO; PR:O35870; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0000785; C:chromatin; IDA:RGD.
DR GO; GO:0005829; C:cytosol; ISO:RGD.
DR GO; GO:0043240; C:Fanconi anaemia nuclear complex; ISS:UniProtKB.
DR GO; GO:0048854; P:brain morphogenesis; ISO:RGD.
DR GO; GO:0034599; P:cellular response to oxidative stress; ISO:RGD.
DR GO; GO:0007276; P:gamete generation; ISO:RGD.
DR GO; GO:0007281; P:germ cell development; ISO:RGD.
DR GO; GO:0036297; P:interstrand cross-link repair; IEA:InterPro.
DR GO; GO:0002262; P:myeloid cell homeostasis; ISO:RGD.
DR GO; GO:0097150; P:neuronal stem cell population maintenance; ISO:RGD.
DR GO; GO:0006289; P:nucleotide-excision repair; ISO:RGD.
DR GO; GO:0006513; P:protein monoubiquitination; ISO:RGD.
DR GO; GO:0019430; P:removal of superoxide radicals; ISO:RGD.
DR InterPro; IPR000686; FANCC.
DR PANTHER; PTHR16798; PTHR16798; 1.
DR Pfam; PF02106; Fanconi_C; 1.
DR PIRSF; PIRSF018417; FACC_protein; 1.
DR PRINTS; PR00494; FANCONICGENE.
PE 2: Evidence at transcript level;
KW Cytoplasm; DNA damage; DNA repair; Nucleus; Reference proteome.
FT CHAIN 1..557
FT /note="Fanconi anemia group C protein homolog"
FT /id="PRO_0000087186"
SQ SEQUENCE 557 AA; 63592 MW; 891658AE09056902 CRC64;
MAQEPADLAS DYQFWLQKLS AWEQASSKET QRDTCLHLSR FQEFLRQMYE LLKEMDSDAI
LERFPSIGQL LAKTCWNPLI LAYDESQKIV IWCLCCLMNK APRTSAESGR NSWIQGLLSH
VLSAFRFDMK EVCLFTKSLG YESIDYYPSL LKNMVLSLVS ELRGSHLNGL NTQSRMAPER
MMSLSQVCVP LVTLPDIEPL VEALLTYHGH EPQEVLSAEF FEAVTEAFLS EKVVLPTSSV
VSLWFRHLPS LEKATLHLFE KLFSSKRNCL RRMECCIKES LLPQAACQPA IFRIVDEMFR
FVLLETDGAP AVLAALQIFT SCLVEALRKE NKQLKFALKT YFPYSAPCLT AALSQQPEAI
PQGHRLQPLL HISQLLREAV EDCTDGSHRN PFESWFLFVH FGGWVDLAVE ELLLREEAEP
PAGLLWLLVF YYSPQDRSQQ REQSMVELKV LVNRLLKLLR SGPLSAMDLL EAAESPREDP
RPVCGQLVRR LLLSLLFWTP EGHAIVWEAV THMAHTDAVT HEIVGFLDQT LYRSHHLCVE
ASRKLARELL KDLQAQV
