FANCF_MOUSE
ID FANCF_MOUSE Reviewed; 343 AA.
AC E9Q5Z5;
DT 11-MAY-2016, integrated into UniProtKB/Swiss-Prot.
DT 05-APR-2011, sequence version 1.
DT 03-AUG-2022, entry version 69.
DE RecName: Full=Fanconi anemia group F protein {ECO:0000250|UniProtKB:Q9NPI8};
DE Short=Protein FACF {ECO:0000250|UniProtKB:Q9NPI8};
GN Name=Fancf {ECO:0000312|MGI:MGI:3689889};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000312|Proteomes:UP000000589};
RN [1] {ECO:0000312|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000312|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000305}
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=21915857; DOI=10.1002/path.2992;
RA Bakker S.T., van de Vrugt H.J., Visser J.A., Delzenne-Goette E.,
RA van der Wal A., Berns M.A., van de Ven M., Oostra A.B., de Vries S.,
RA Kramer P., Arwert F., van der Valk M., de Winter J.P., te Riele H.;
RT "Fancf-deficient mice are prone to develop ovarian tumours.";
RL J. Pathol. 226:28-39(2012).
CC -!- FUNCTION: DNA repair protein that may operate in a postreplication
CC repair or a cell cycle checkpoint function. May be implicated in
CC interstrand DNA cross-link repair and in the maintenance of normal
CC chromosome stability. {ECO:0000269|PubMed:21915857}.
CC -!- SUBUNIT: Belongs to the multisubunit FA complex composed of FANCA,
CC FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and FANCM. In complex
CC with FANCA, FANCG and FANCL, but not with FANCC, nor FANCE, interacts
CC with HES1; this interaction may be essential for the stability and
CC nuclear localization of FA core complex proteins.
CC {ECO:0000250|UniProtKB:Q9NPI8}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9NPI8}.
CC -!- DISRUPTION PHENOTYPE: Viable with no gross developmental abnormalities
CC or significant growth retardation. Gonad defects are present in both
CC male and female mice. Testes are devoid of germ cells. Ovaries show
CC premature depletion of primordial follicles with almost complete loss
CC by 14 weeks of age, and aberrant estrous cycle. Significantly increased
CC incidence of tumors, particularly ovarian tumors.
CC {ECO:0000269|PubMed:21915857}.
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DR EMBL; AC158345; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS52261.1; -.
DR RefSeq; NP_001108559.1; NM_001115087.1.
DR AlphaFoldDB; E9Q5Z5; -.
DR SMR; E9Q5Z5; -.
DR STRING; 10090.ENSMUSP00000125812; -.
DR iPTMnet; E9Q5Z5; -.
DR PhosphoSitePlus; E9Q5Z5; -.
DR EPD; E9Q5Z5; -.
DR MaxQB; E9Q5Z5; -.
DR PaxDb; E9Q5Z5; -.
DR PRIDE; E9Q5Z5; -.
DR ProteomicsDB; 267711; -.
DR Antibodypedia; 25340; 195 antibodies from 27 providers.
DR Ensembl; ENSMUST00000169357; ENSMUSP00000125812; ENSMUSG00000092118.
DR GeneID; 100040608; -.
DR KEGG; mmu:100040608; -.
DR UCSC; uc012flg.2; mouse.
DR CTD; 2188; -.
DR MGI; MGI:3689889; Fancf.
DR VEuPathDB; HostDB:ENSMUSG00000092118; -.
DR eggNOG; ENOG502S2Z3; Eukaryota.
DR GeneTree; ENSGT00390000005623; -.
DR HOGENOM; CLU_770617_0_0_1; -.
DR InParanoid; E9Q5Z5; -.
DR OMA; LQWARYL; -.
DR OrthoDB; 1404593at2759; -.
DR PhylomeDB; E9Q5Z5; -.
DR TreeFam; TF332957; -.
DR Reactome; R-MMU-6783310; Fanconi Anemia Pathway.
DR BioGRID-ORCS; 100040608; 22 hits in 110 CRISPR screens.
DR ChiTaRS; Fancf; mouse.
DR PRO; PR:E9Q5Z5; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; E9Q5Z5; protein.
DR Bgee; ENSMUSG00000092118; Expressed in optic fissure and 233 other tissues.
DR Genevisible; E9Q5Z5; MM.
DR GO; GO:0000785; C:chromatin; ISO:MGI.
DR GO; GO:0043240; C:Fanconi anaemia nuclear complex; IMP:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IMP:MGI.
DR GO; GO:0006974; P:cellular response to DNA damage stimulus; IMP:MGI.
DR GO; GO:0036297; P:interstrand cross-link repair; IEA:InterPro.
DR GO; GO:0001541; P:ovarian follicle development; IMP:MGI.
DR GO; GO:0006513; P:protein monoubiquitination; ISO:MGI.
DR GO; GO:0016567; P:protein ubiquitination; IMP:MGI.
DR GO; GO:0007283; P:spermatogenesis; IMP:MGI.
DR Gene3D; 1.25.40.490; -; 1.
DR InterPro; IPR035428; FANCF.
DR InterPro; IPR038505; FANCF_C_sf.
DR PANTHER; PTHR14449; PTHR14449; 1.
DR Pfam; PF11107; FANCF; 1.
PE 3: Inferred from homology;
KW DNA damage; DNA repair; Nucleus; Reference proteome.
FT CHAIN 1..343
FT /note="Fanconi anemia group F protein"
FT /id="PRO_0000436204"
SQ SEQUENCE 343 AA; 38224 MW; AB6794BF903F4FB6 CRC64;
MEPLVQQTER FSELLAVSCG SLVSTWDAEK VRRALQWARY LLHVYRRFAG RGRVREALER
RLPARGGPLG LRSFAALESG DARLALRLLR NRALAPAAAR ALPSLLFPGP AADHRDDVPQ
SRLVLLARRG SALRLLCRLG GDAPRSALLR THAELLDARL HELGGADSAA ARKLLDTLWT
RGPREHVLDV TAEALLLREE DPEPAQATDP AGADETQKLL RWLLESPEVL AAFCRHLPAK
RLASVAGCHH ALSRAYLDLL TTWATRLHYD LQKGAWVPTQ MEDMPWEELC LRLQSLCHAQ
PFLQEEVLVT LRSRKALDGD FEVPGMSIWT DLLVVLECGI VLE
