FANCG_MOUSE
ID FANCG_MOUSE Reviewed; 623 AA.
AC Q9EQR6; A2AG34;
DT 16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Fanconi anemia group G protein homolog;
DE Short=Protein FACG;
GN Name=Fancg;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11093276; DOI=10.1038/sj.ejhg.5200552;
RA Demuth I., Wlodarski M., Tipping A.J., Morgan N.V., de Winter J.P.,
RA Thiel M., Grasl S., Schindler D., D'Andrea A.D., Altay C., Kayserili H.,
RA Zatterale A., Kunze J., Ebell W., Mathew C.G., Joenje H., Sperling K.,
RA Digweed M.;
RT "Spectrum of mutations in the Fanconi anaemia group G gene, FANCG/XRCC9.";
RL Eur. J. Hum. Genet. 8:861-868(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RC STRAIN=FVB/NJ;
RX PubMed=11918676; DOI=10.1046/j.1365-2443.2002.00518.x;
RA van de Vrugt H.J., Koomen M., Berns M.A., de Vries Y., Rooimans M.A.,
RA van der Weel L., Blom E., de Groot J., Schepers R.J., Stone S.,
RA Hoatlin M.E., Cheng N.C., Joenje H., Arwert F.;
RT "Characterization, expression and complex formation of the murine Fanconi
RT anaemia gene product Fancg.";
RL Genes Cells 7:333-342(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- FUNCTION: DNA repair protein that may operate in a postreplication
CC repair or a cell cycle checkpoint function. May be implicated in
CC interstrand DNA cross-link repair and in the maintenance of normal
CC chromosome stability. Candidate tumor suppressor gene (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Belongs to the multisubunit FA complex composed of FANCA,
CC FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and FANCM. In complex
CC with FANCF, FANCA and FANCL, but not with FANCC, nor FANCE, interacts
CC with HES1; this interaction may be essential for the stability and
CC nuclear localization of FA core complex proteins. The complex with
CC FANCC and FANCG may also include EIF2AK2 and HSP70. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11918676}.
CC -!- TISSUE SPECIFICITY: Highest expression levels in spleen, thymus and
CC testis. {ECO:0000269|PubMed:11918676}.
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DR EMBL; AF112439; AAG43198.1; -; mRNA.
DR EMBL; AY049715; AAL12165.1; -; mRNA.
DR EMBL; AL672276; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS18087.1; -.
DR RefSeq; NP_001156705.1; NM_001163233.1.
DR RefSeq; NP_444311.1; NM_053081.2.
DR RefSeq; XP_006538190.1; XM_006538127.2.
DR RefSeq; XP_006538191.1; XM_006538128.2.
DR AlphaFoldDB; Q9EQR6; -.
DR SMR; Q9EQR6; -.
DR BioGRID; 208603; 1.
DR STRING; 10090.ENSMUSP00000030165; -.
DR iPTMnet; Q9EQR6; -.
DR PhosphoSitePlus; Q9EQR6; -.
DR EPD; Q9EQR6; -.
DR MaxQB; Q9EQR6; -.
DR PaxDb; Q9EQR6; -.
DR PRIDE; Q9EQR6; -.
DR ProteomicsDB; 277040; -.
DR Antibodypedia; 25694; 449 antibodies from 37 providers.
DR DNASU; 60534; -.
DR Ensembl; ENSMUST00000030165; ENSMUSP00000030165; ENSMUSG00000028453.
DR GeneID; 60534; -.
DR KEGG; mmu:60534; -.
DR UCSC; uc008sos.2; mouse.
DR CTD; 2189; -.
DR MGI; MGI:1926471; Fancg.
DR VEuPathDB; HostDB:ENSMUSG00000028453; -.
DR eggNOG; ENOG502QVUI; Eukaryota.
DR GeneTree; ENSGT00390000007195; -.
DR HOGENOM; CLU_018870_0_0_1; -.
DR InParanoid; Q9EQR6; -.
DR OMA; GAASNCE; -.
DR OrthoDB; 358660at2759; -.
DR PhylomeDB; Q9EQR6; -.
DR TreeFam; TF330722; -.
DR Reactome; R-MMU-6783310; Fanconi Anemia Pathway.
DR BioGRID-ORCS; 60534; 36 hits in 109 CRISPR screens.
DR ChiTaRS; Fancg; mouse.
DR PRO; PR:Q9EQR6; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q9EQR6; protein.
DR Bgee; ENSMUSG00000028453; Expressed in spermatocyte and 175 other tissues.
DR Genevisible; Q9EQR6; MM.
DR GO; GO:0000785; C:chromatin; ISO:MGI.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0043240; C:Fanconi anaemia nuclear complex; ISS:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; ISO:MGI.
DR GO; GO:0005730; C:nucleolus; ISO:MGI.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0006974; P:cellular response to DNA damage stimulus; IMP:MGI.
DR GO; GO:0036297; P:interstrand cross-link repair; IEA:InterPro.
DR GO; GO:0007005; P:mitochondrion organization; ISO:MGI.
DR GO; GO:0001541; P:ovarian follicle development; IMP:MGI.
DR GO; GO:0006513; P:protein monoubiquitination; ISO:MGI.
DR GO; GO:0009314; P:response to radiation; IMP:MGI.
DR GO; GO:0007286; P:spermatid development; IMP:MGI.
DR Gene3D; 1.25.40.10; -; 1.
DR InterPro; IPR039684; FANCG.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR15254; PTHR15254; 1.
DR SMART; SM00028; TPR; 3.
DR SUPFAM; SSF48452; SSF48452; 2.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 2: Evidence at transcript level;
KW DNA damage; DNA repair; Nucleus; Reference proteome; Repeat; TPR repeat.
FT CHAIN 1..623
FT /note="Fanconi anemia group G protein homolog"
FT /id="PRO_0000106293"
FT REPEAT 251..284
FT /note="TPR 1"
FT REPEAT 349..382
FT /note="TPR 2"
FT REPEAT 458..491
FT /note="TPR 3"
FT REPEAT 517..550
FT /note="TPR 4"
SQ SEQUENCE 623 AA; 68506 MW; 061586EF186F74AF CRC64;
MSSQVIPALP KTFSSSLDLW REKNDQLVRQ AKQLTRDSRP SLRRQQSAQD TLEGLRELLL
TLQGLPAAVP ALPLELTVLC NCIILRASLV QAFTEDLTQD LQRGLERVLE AQHHLEPKSQ
QGLKELWHSV LSASSLPPEL LPALHCLASL QAVFWMSTDH LEDLTLLLQT LNGSQTQSSE
DLLLLLKSWS PPAEESPAPL ILQDAESLRD VLLTAFACRQ GFQELITGSL PHAQSNLHEA
ASGLCPPSVL VQVYTALGAC LRKMGNPQRA LLYLTEALKV GTTCALPLLE ASRVYRQLGD
RAAELESLEL LVEALSATHS SETFKSLIEV ELLLPQPDPA SPLHCGTQSQ AKHLLASRCL
QTGRAEDAAE HYLDLLAMLL GGSETRFSPP TSSLGPCIPE LCLEAAAALI QAGRALDALT
VCEELLNRTS SLLPKMSSLW ENARKRAKEL PCCPVWVSAT HLLQGQAWSQ LKAQKEALSE
FSQCLELLFR TLPEDKEQGS DCEQKCRSDV ALKQLRVAAL ISRGLEWVAS GQDTKALSDF
LLSVQICPGN RDGSFYLLQT LKRLDRKNEA SAFWREAHSQ LPLEDAAGSL PLYLETCLSW
IHPPNREAFL EEFGTSVLES CVL
