ID   FAND_ECOLX              Reviewed;         783 AA.
AC   P12050;
DT   01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1989, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Outer membrane usher protein FanD;
DE   Flags: Precursor;
GN   Name=fanD;
OS   Escherichia coli.
OG   Plasmid pFK99.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=562;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=B41;
RX   PubMed=2564179; DOI=10.1093/nar/17.3.1263;
RA   Roosendaal B., Bakker D., de Graaf F.K.;
RT   "The nucleotide sequence of the fanD gene encoding the large outer membrane
RT   protein involved in the biosynthesis of K99 fimbriae.";
RL   Nucleic Acids Res. 17:1263-1263(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-20.
RA   Roosendaal B., Gaastra W., de Graaf F.K.;
RT   "The nucleotide sequence of the gene encoding the K99 subunit of
RT   enterotoxigenic Escherichia coli.";
RL   FEMS Microbiol. Lett. 22:253-258(1984).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 770-783.
RC   STRAIN=B41;
RX   PubMed=1713284; DOI=10.1111/j.1365-2958.1991.tb00761.x;
RA   Bakker D., Vader C.E.M., Roosendaal B., Mooi F.R., Oudega B.,
RA   de Graaf F.K.;
RT   "Structure and function of periplasmic chaperone-like proteins involved in
RT   the biosynthesis of K88 and K99 fimbriae in enterotoxigenic Escherichia
RT   coli.";
RL   Mol. Microbiol. 5:875-886(1991).
CC   -!- FUNCTION: Involved in the export and assembly of K99 fimbrial subunits
CC       across the outer membrane.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the fimbrial export usher family. {ECO:0000305}.
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DR   EMBL; X13560; CAA31911.1; -; Genomic_DNA.
DR   EMBL; M35282; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; X56001; CAA39473.1; -; Genomic_DNA.
DR   PIR; S02755; S02755.
DR   AlphaFoldDB; P12050; -.
DR   SMR; P12050; -.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015473; F:fimbrial usher porin activity; IEA:InterPro.
DR   GO; GO:0009297; P:pilus assembly; IEA:InterPro.
DR   Gene3D; 2.60.40.2610; -; 1.
DR   Gene3D; 3.10.20.410; -; 1.
DR   InterPro; IPR000015; Fimb_usher.
DR   InterPro; IPR018030; Fimbrial_membr_usher_CS.
DR   InterPro; IPR042186; FimD_plug_dom.
DR   InterPro; IPR025885; PapC_N.
DR   InterPro; IPR037224; PapC_N_sf.
DR   PANTHER; PTHR30451; PTHR30451; 1.
DR   Pfam; PF13954; PapC_N; 1.
DR   Pfam; PF00577; Usher; 1.
DR   SUPFAM; SSF141729; SSF141729; 1.
DR   PROSITE; PS01151; FIMBRIAL_USHER; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Disulfide bond; Fimbrium biogenesis; Membrane;
KW   Plasmid; Signal; Transmembrane; Transmembrane beta strand; Transport.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..783
FT                   /note="Outer membrane usher protein FanD"
FT                   /id="PRO_0000009309"
FT   DISULFID        763..782
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   783 AA;  87157 MW;  23BDE3923A9B7069 CRC64;
     MNRKKHQILK ILLLCLISSK SSASEKELNL QFIRHKFGQN TEDIELFFNS STVLPGNYTV
     DVKLNDEVIG RAKLEVSQDD KESYCLKDEW LSDLGIIINR DFYNKYFNIK RECYEIGKEK
     NSITTFDNNS QIFSLYMPQA AYIKKGNTEH KWSYGDPGFN LNYDAYLSKN DEDSSIYGNL
     EGNVNIDKWV LYGRGYKYEH DKFTTDDVTL SRAIKSLEGD LIIGDTYTNT SLMDNISFYG
     VQLRSNNAMT PERRGDYSPI ISGIAKSNAR VTVKQNGVVL HSELVSPGPF HINNVRGIRS
     GELVMTVTEE DGSEQQTRIP VTFIANLLSP GNYNYDFGIG NKEATWEPDN IFAYGSFDYG
     LNLLTLNASL LFEQHYSNAG IGAVGSIGSL GAVSVSGNIS RAKNQLETDQ GYSTSANYSK
     NVGANGNLQI IGYKFSSEGY TQYANFDYRA PRKDKKEKER YEVTLTQQFP ASNVFLSVTG
     WKKFYWNDNS VTGANVSYTQ NFGTVNASVN GSYSRGDGAK SDYMLGFNIN IPFRHNDRQF
     YSNSGVTYNR NSGIGFNAGF SEDVTKNFNY NVNAAASKDN ESVSLSTNYT SSMFRTSASV
     SKNRNSTNAS AQIGGAIIGV KDGGVMLTSM SSNSVAIVQM EGLAGYAFTN GVESDWRGRI
     AYPMTTYMDN DIQISTDKLP SNIELTDNVE TIVPTNRAIK LQKIKYKNMS RHVLKVYDKN
     GFVIPMGTAV KNSNGEIISF VNNNGISLLN IDKNDERVFF GSCTISTSGL KDNLSEIQEV
     NCE