ID   FANF_ECOLX              Reviewed;         333 AA.
AC   P25448;
DT   01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1992, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Protein FanF;
DE   Flags: Precursor;
GN   Name=fanF;
OS   Escherichia coli.
OG   Plasmid pFK99.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=562;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1982454; DOI=10.1111/j.1365-2958.1990.tb00564.x;
RA   Simons B.L., Willemsen P.T.J., Bakker D., Roosendaal B., de Graaf F.K.,
RA   Oudega B.;
RT   "Structure, localization and function of FanF, a minor component of K99
RT   fibrillae of enterotoxigenic Escherichia coli.";
RL   Mol. Microbiol. 4:2041-2050(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7908067;
RA   Abe N., Moriishi K., Saito M., Naiki M.;
RT   "Confirmed nucleotide sequence of fanF of Escherichia coli K99 fimbriae.";
RL   Jpn. J. Vet. Res. 41:97-99(1993).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-13.
RX   PubMed=1713284; DOI=10.1111/j.1365-2958.1991.tb00761.x;
RA   Bakker D., Vader C.E.M., Roosendaal B., Mooi F.R., Oudega B.,
RA   de Graaf F.K.;
RT   "Structure and function of periplasmic chaperone-like proteins involved in
RT   the biosynthesis of K88 and K99 fimbriae in enterotoxigenic Escherichia
RT   coli.";
RL   Mol. Microbiol. 5:875-886(1991).
CC   -!- FUNCTION: Minor component of K99 fimbriae. Is not required for binding
CC       of K99 fimbriae to the ganglioside receptor. May play a role in
CC       initiation, elongation and flexibility of the fimbriae.
CC   -!- SUBCELLULAR LOCATION: Fimbrium. Note=At the tip and in or along the
CC       sides of the K99 fimbriae.
CC   -!- PTM: Three disulfide bonds are present. {ECO:0000305}.
CC   -!- MISCELLANEOUS: Requires the FanE protein for its stability.
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DR   EMBL; X56001; CAA39475.1; -; Genomic_DNA.
DR   EMBL; S70131; AAB30306.1; -; Genomic_DNA.
DR   PIR; S12392; S12392.
DR   RefSeq; WP_000792596.1; NZ_NLNM01000061.1.
DR   AlphaFoldDB; P25448; -.
DR   GO; GO:0009289; C:pilus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR008966; Adhesion_dom_sf.
DR   SUPFAM; SSF49401; SSF49401; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Fimbrium; Plasmid; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..333
FT                   /note="Protein FanF"
FT                   /id="PRO_0000009204"
SQ   SEQUENCE   333 AA;  36484 MW;  6132CDEE19894EAA CRC64;
     MKNKYNLLFF LFLLCYGDVA LAACTGKLKI SPGYSGHTYS FDSSIPNNSN IARYLVEISE
     KIVCDADQSG WDGKRYAQLH LYSSGALCES VSGDGITFRS NVSGLSWRFP NGIPYHCAAG
     QINLGGIKYA DRNGKVTWNP GELRHEIFLR VDNRFDFSKS RTFSVNTISG RGGLGGDSSV
     VIPLIGSSFN YSYSNIATCT LTGPSEVNFN TVTTSDVLKG TTHRDLNLRA ECRNRGASLG
     LNFKFEPQYK DVSANKQGVF YAKNTSGSLT YKLTKKADAS AIPLNEFVKL IVEDKVNIHT
     GNTIPLLLTL QKGDGKIATG KIETFLNVTM EHM