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FAN_MOUSE
ID   FAN_MOUSE               Reviewed;         920 AA.
AC   O35242; A2AKK1;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 2.
DT   03-AUG-2022, entry version 155.
DE   RecName: Full=Protein FAN;
DE   AltName: Full=Factor associated with neutral sphingomyelinase activation;
DE            Short=Factor associated with N-SMase activation;
GN   Name=Nsmaf; Synonyms=Fan;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Thymus;
RX   PubMed=10228161; DOI=10.1093/emboj/18.9.2472;
RA   Kreder D., Krut O., Adam-Klages S., Wiegmann K., Scherer G., Plitz T.,
RA   Jensen J.M., Proksch E., Steinmann J., Pfeffer K., Kroenke M.;
RT   "Impaired neutral sphingomyelinase activation and cutaneous barrier repair
RT   in FAN-deficient mice.";
RL   EMBO J. 18:2472-2479(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Spleen;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: Couples the p55 TNF-receptor (TNF-R55 / TNFR1) to neutral
CC       sphingomyelinase (N-SMASE). Specifically binds to the N-smase
CC       activation domain of TNF-R55. May regulate ceramide production by N-
CC       SMASE.
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DR   EMBL; AF013632; AAB65394.1; -; mRNA.
DR   EMBL; AL772306; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BX510318; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH466538; EDL05686.1; -; Genomic_DNA.
DR   EMBL; BC145961; AAI45962.1; -; mRNA.
DR   EMBL; BC145963; AAI45964.1; -; mRNA.
DR   CCDS; CCDS17952.1; -.
DR   RefSeq; NP_035075.2; NM_010945.2.
DR   AlphaFoldDB; O35242; -.
DR   SMR; O35242; -.
DR   STRING; 10090.ENSMUSP00000029910; -.
DR   iPTMnet; O35242; -.
DR   PhosphoSitePlus; O35242; -.
DR   EPD; O35242; -.
DR   MaxQB; O35242; -.
DR   PaxDb; O35242; -.
DR   PeptideAtlas; O35242; -.
DR   PRIDE; O35242; -.
DR   ProteomicsDB; 267570; -.
DR   Antibodypedia; 11802; 126 antibodies from 24 providers.
DR   DNASU; 18201; -.
DR   Ensembl; ENSMUST00000029910; ENSMUSP00000029910; ENSMUSG00000028245.
DR   GeneID; 18201; -.
DR   KEGG; mmu:18201; -.
DR   UCSC; uc008rxp.2; mouse.
DR   CTD; 8439; -.
DR   MGI; MGI:1341864; Nsmaf.
DR   VEuPathDB; HostDB:ENSMUSG00000028245; -.
DR   eggNOG; KOG1786; Eukaryota.
DR   GeneTree; ENSGT00940000155059; -.
DR   HOGENOM; CLU_000218_5_2_1; -.
DR   InParanoid; O35242; -.
DR   OMA; QVYKRRY; -.
DR   OrthoDB; 101142at2759; -.
DR   PhylomeDB; O35242; -.
DR   TreeFam; TF324912; -.
DR   Reactome; R-MMU-5626978; TNFR1-mediated ceramide production.
DR   BioGRID-ORCS; 18201; 4 hits in 76 CRISPR screens.
DR   ChiTaRS; Nsmaf; mouse.
DR   PRO; PR:O35242; -.
DR   Proteomes; UP000000589; Chromosome 4.
DR   RNAct; O35242; protein.
DR   Bgee; ENSMUSG00000028245; Expressed in undifferentiated genital tubercle and 260 other tissues.
DR   ExpressionAtlas; O35242; baseline and differential.
DR   Genevisible; O35242; MM.
DR   GO; GO:0005123; F:death receptor binding; TAS:MGI.
DR   GO; GO:0016230; F:sphingomyelin phosphodiesterase activator activity; ISO:MGI.
DR   GO; GO:0043065; P:positive regulation of apoptotic process; ISO:MGI.
DR   CDD; cd06071; Beach; 1.
DR   CDD; cd01201; PH_BEACH; 1.
DR   Gene3D; 1.10.1540.10; -; 1.
DR   Gene3D; 2.130.10.10; -; 3.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR000409; BEACH_dom.
DR   InterPro; IPR036372; BEACH_dom_sf.
DR   InterPro; IPR004182; GRAM.
DR   InterPro; IPR023362; PH-BEACH_dom.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF02138; Beach; 1.
DR   Pfam; PF02893; GRAM; 1.
DR   Pfam; PF00400; WD40; 3.
DR   SMART; SM01026; Beach; 1.
DR   SMART; SM00568; GRAM; 1.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   SUPFAM; SSF81837; SSF81837; 1.
DR   PROSITE; PS50197; BEACH; 1.
DR   PROSITE; PS51783; PH_BEACH; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 4.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   1: Evidence at protein level;
KW   Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..920
FT                   /note="Protein FAN"
FT                   /id="PRO_0000050976"
FT   DOMAIN          176..247
FT                   /note="GRAM"
FT   DOMAIN          189..286
FT                   /note="BEACH-type PH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01119"
FT   DOMAIN          290..575
FT                   /note="BEACH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00026"
FT   REPEAT          631..661
FT                   /note="WD 1"
FT   REPEAT          673..703
FT                   /note="WD 2"
FT   REPEAT          715..743
FT                   /note="WD 3"
FT   REPEAT          764..794
FT                   /note="WD 4"
FT   REPEAT          806..836
FT                   /note="WD 5"
FT   REPEAT          887..917
FT                   /note="WD 6"
FT   CONFLICT        385..386
FT                   /note="RF -> KS (in Ref. 1; AAB65394)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        390
FT                   /note="S -> N (in Ref. 1; AAB65394)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        849
FT                   /note="E -> D (in Ref. 1; AAB65394)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   920 AA;  104546 MW;  BB50AD4AB77CE124 CRC64;
     MAFTRKRQRE QQLQLYSKER FSLLLLNLEE YYFEQHTAFH VQHQGSQEER KIRGSLKICS
     KSVIFEPDAI SQPILKIPLR DCLKIGKHGE NGANKHFAKA KSWGISLIFS QIYFIKEHNI
     VAPYKIERGK MEYVFELEVS GKVEDVVETL LQLHRASCLD KLGDQMAMIT AILQSRLART
     SFDKNRFQSV SEKLHMECKA EMVTPLVTNP GHVCITDTSL YFQPLNGYPK PVVQITLQDV
     RRIYKRRHGL MPLGLEVFCT DDDLCSDIYL KFYEPQDRDD LYFYIATYLE HHAAEHTAES
     YMLQWQRGHL SNYQYLLHLN NLADRSCNDL SQYPVFPWII SDYSSPELDL SNPATFRDLS
     KPVGALNAER LERLLTRYQE MPEPRFMYGS HYSSPGYVLF YLVRIAPEYM LCLQNGRFDN
     ADRMFNSIAE TWKNCLDGAT DFKELIPEFY DEDVSFLVNS LKLDLGKRQG GQMVDDVDLP
     AWASSPQDFL QKNKDALESG YVSEHLHEWI DLIFGYKQKG SEAIGAHNVF HPLTYEGGVD
     LNSIEDPDEK VAMLTQILEF GQTPKQLFVT PHPRRITPKF KSLSQASSYN ASLTDSPVSP
     GEESFEDLTE ESRTLAWSNI AKLQLHEQYK IHKEAVTGIA VSCNGSSVFT TSQDSTLKMF
     SKESKMLQRS ISFSNMALSS CLLLPGDTTV ISSSWDNNVY FYSIAFGRRQ DTLMGHDDAV
     SKICWHNDRL YSGSWDSTVK VWSGVPAEMP GTKRHQFDLL AELEHDVSVN TINLNAVSTL
     LVSGTKEGMV NIWDLTTATL LHQTSCHSGT VCDAAFSPDS RHILSTGVDG CLNVIDVQTG
     MLISSMASEE PQRCFVWDGN SVLSGSRSGE LLVWDLLGAK VSERIQGHTG AVTCMWMNEQ
     CSSIITGGED RQIMFWKLQY
 
 
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