ID   FAP24_BOVIN             Reviewed;         215 AA.
AC   Q2KHY5;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Fanconi anemia core complex-associated protein 24 {ECO:0000250|UniProtKB:Q9BTP7};
DE   AltName: Full=Fanconi anemia-associated protein of 24 kDa;
GN   Name=FAAP24 {ECO:0000250|UniProtKB:Q9BTP7};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hypothalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role in DNA repair through recruitment of the FA core
CC       complex to damaged DNA. Regulates FANCD2 monoubiquitination upon DNA
CC       damage. Induces chromosomal instability as well as hypersensitivity to
CC       DNA cross-linking agents, when repressed. Targets FANCM/FAAP24 complex
CC       to the DNA, preferentially to single strand DNA (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Belongs to the multisubunit FA complex composed of FANCA,
CC       FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9, FANCM and FAAP24.
CC       Interacts with FANCM (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- DOMAIN: The C-terminal region is distantly related to RuvA domain 2, a
CC       DNA-binding domain.
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DR   EMBL; BC112837; AAI12838.1; -; mRNA.
DR   RefSeq; NP_001039527.1; NM_001046062.2.
DR   AlphaFoldDB; Q2KHY5; -.
DR   SMR; Q2KHY5; -.
DR   STRING; 9913.ENSBTAP00000055729; -.
DR   PaxDb; Q2KHY5; -.
DR   PRIDE; Q2KHY5; -.
DR   Ensembl; ENSBTAT00000013731; ENSBTAP00000013731; ENSBTAG00000010403.
DR   Ensembl; ENSBTAT00000065656; ENSBTAP00000055729; ENSBTAG00000010403.
DR   GeneID; 510793; -.
DR   KEGG; bta:510793; -.
DR   CTD; 91442; -.
DR   VEuPathDB; HostDB:ENSBTAG00000010403; -.
DR   VGNC; VGNC:28694; FAAP24.
DR   eggNOG; KOG2841; Eukaryota.
DR   GeneTree; ENSGT00390000009456; -.
DR   HOGENOM; CLU_111628_0_0_1; -.
DR   InParanoid; Q2KHY5; -.
DR   OMA; RHFSSIQ; -.
DR   OrthoDB; 1471232at2759; -.
DR   Reactome; R-BTA-6783310; Fanconi Anemia Pathway.
DR   Proteomes; UP000009136; Chromosome 18.
DR   Bgee; ENSBTAG00000010403; Expressed in oocyte and 106 other tissues.
DR   GO; GO:0000785; C:chromatin; IEA:Ensembl.
DR   GO; GO:0071821; C:FANCM-MHF complex; IEA:Ensembl.
DR   GO; GO:0043240; C:Fanconi anaemia nuclear complex; IBA:GO_Central.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0036297; P:interstrand cross-link repair; IEA:Ensembl.
DR   InterPro; IPR041663; DisA/LigA_HHH.
DR   InterPro; IPR026985; FAAP24.
DR   InterPro; IPR040646; PND.
DR   InterPro; IPR010994; RuvA_2-like.
DR   PANTHER; PTHR31786; PTHR31786; 1.
DR   Pfam; PF12826; HHH_2; 1.
DR   Pfam; PF17949; PND; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
PE   2: Evidence at transcript level;
KW   DNA damage; DNA repair; DNA-binding; Nucleus; Reference proteome.
FT   CHAIN           1..215
FT                   /note="Fanconi anemia core complex-associated protein 24"
FT                   /id="PRO_0000270960"
SQ   SEQUENCE   215 AA;  23879 MW;  C3C379A3D76D3239 CRC64;
     MESNPPDSTG PMHVPFGHIV ANEKWRGSQL AQGMQGKIKL VFEDGLTPVD FYLSSKSCIL
     YITEAELVAG NGYRKRLVRV RNSNKLQGIV VVEKTQMSEQ YFPAVQKFTV LDLGMVLLPV
     ASQMEASCLI IQLVQEQTRE PSKNPFLRKK RALVSEPALL RSVQQIPGVG KVKAPLLLQR
     FPSIQQLSNA SLRELEAVVG PAAAQRIHAF FSQPR