FAP24_MOUSE
ID FAP24_MOUSE Reviewed; 221 AA.
AC Q8BHL6; Q3TLJ2;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Fanconi anemia core complex-associated protein 24 {ECO:0000250|UniProtKB:Q9BTP7};
DE AltName: Full=Fanconi anemia-associated protein of 24 kDa;
GN Name=Faap24 {ECO:0000250|UniProtKB:Q9BTP7};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Cerebellum, Mammary gland, Testis, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Plays a role in DNA repair through recruitment of the FA core
CC complex to damaged DNA. Regulates FANCD2 monoubiquitination upon DNA
CC damage. Induces chromosomal instability as well as hypersensitivity to
CC DNA cross-linking agents, when repressed. Targets FANCM/FAAP24 complex
CC to the DNA, preferentially to single strand DNA (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Belongs to the multisubunit FA complex composed of FANCA,
CC FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9, FANCM and FAAP24.
CC Interacts with FANCM (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- DOMAIN: The C-terminal region is distantly related to RuvA domain 2, a
CC DNA-binding domain.
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DR EMBL; AK031566; BAC27452.1; -; mRNA.
DR EMBL; AK040248; BAC30550.1; -; mRNA.
DR EMBL; AK082457; BAC38495.1; -; mRNA.
DR EMBL; AK166481; BAE38800.1; -; mRNA.
DR EMBL; BC096687; AAH96687.1; -; mRNA.
DR CCDS; CCDS21149.1; -.
DR RefSeq; NP_848758.1; NM_178643.5.
DR AlphaFoldDB; Q8BHL6; -.
DR SMR; Q8BHL6; -.
DR BioGRID; 221736; 1.
DR STRING; 10090.ENSMUSP00000032704; -.
DR PhosphoSitePlus; Q8BHL6; -.
DR PaxDb; Q8BHL6; -.
DR PRIDE; Q8BHL6; -.
DR ProteomicsDB; 267715; -.
DR Antibodypedia; 47946; 40 antibodies from 13 providers.
DR DNASU; 101831; -.
DR Ensembl; ENSMUST00000032704; ENSMUSP00000032704; ENSMUSG00000030493.
DR Ensembl; ENSMUST00000154597; ENSMUSP00000115766; ENSMUSG00000030493.
DR GeneID; 101831; -.
DR KEGG; mmu:101831; -.
DR UCSC; uc009gjt.1; mouse.
DR CTD; 91442; -.
DR MGI; MGI:2142208; Faap24.
DR VEuPathDB; HostDB:ENSMUSG00000030493; -.
DR eggNOG; KOG2841; Eukaryota.
DR GeneTree; ENSGT00390000009456; -.
DR HOGENOM; CLU_111628_0_0_1; -.
DR InParanoid; Q8BHL6; -.
DR OMA; RHFSSIQ; -.
DR OrthoDB; 1471232at2759; -.
DR PhylomeDB; Q8BHL6; -.
DR TreeFam; TF333015; -.
DR Reactome; R-MMU-6783310; Fanconi Anemia Pathway.
DR BioGRID-ORCS; 101831; 8 hits in 74 CRISPR screens.
DR ChiTaRS; Faap24; mouse.
DR PRO; PR:Q8BHL6; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q8BHL6; protein.
DR Bgee; ENSMUSG00000030493; Expressed in fetal liver hematopoietic progenitor cell and 241 other tissues.
DR Genevisible; Q8BHL6; MM.
DR GO; GO:0000785; C:chromatin; ISO:MGI.
DR GO; GO:0071821; C:FANCM-MHF complex; ISO:MGI.
DR GO; GO:0043240; C:Fanconi anaemia nuclear complex; ISS:UniProtKB.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0003682; F:chromatin binding; ISS:UniProtKB.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0036297; P:interstrand cross-link repair; ISO:MGI.
DR InterPro; IPR041663; DisA/LigA_HHH.
DR InterPro; IPR026985; FAAP24.
DR InterPro; IPR040646; PND.
DR InterPro; IPR010994; RuvA_2-like.
DR PANTHER; PTHR31786; PTHR31786; 1.
DR Pfam; PF12826; HHH_2; 1.
DR Pfam; PF17949; PND; 1.
DR SUPFAM; SSF47781; SSF47781; 1.
PE 2: Evidence at transcript level;
KW DNA damage; DNA repair; DNA-binding; Nucleus; Reference proteome.
FT CHAIN 1..221
FT /note="Fanconi anemia core complex-associated protein 24"
FT /id="PRO_0000270962"
FT CONFLICT 175
FT /note="P -> R (in Ref. 1; BAE38800)"
FT /evidence="ECO:0000305"
FT CONFLICT 220
FT /note="R -> H (in Ref. 1; BAE38800)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 221 AA; 24641 MW; 0855496BB283E4BB CRC64;
MERNPPDGTG PVHVPLGHIV ASEKWRGSQL AQEMQGKVRL IFEEGLASAD FYLSSKSCIL
YVTEADLVAG HGYRKRLARF RNSSHLQGII IVEKTQMSEQ YFPAVQKFTV LDLGMVLLPV
ASQSEASCLI IHLVQEQTRE PSKNPFLRKK RSMLSELSLV QTVQQIPGVG KVKAPLLLQK
FPSIQQLSNA SVQELEEVVG PAAAQQIHTF FTQPKRQQPR S
