FAPR_ALKCK
ID FAPR_ALKCK Reviewed; 191 AA.
AC Q5WFM1;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 25-MAY-2022, entry version 102.
DE RecName: Full=Transcription factor FapR {ECO:0000255|HAMAP-Rule:MF_01814};
DE AltName: Full=Fatty acid and phospholipid biosynthesis regulator {ECO:0000255|HAMAP-Rule:MF_01814};
GN Name=fapR {ECO:0000255|HAMAP-Rule:MF_01814}; OrderedLocusNames=ABC2304;
OS Alkalihalobacillus clausii (strain KSM-K16) (Bacillus clausii).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Alkalihalobacillus.
OX NCBI_TaxID=66692;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSM-K16;
RA Takaki Y., Kageyama Y., Shimamura S., Suzuki H., Nishi S., Hatada Y.,
RA Kawai S., Ito S., Horikoshi K.;
RT "The complete genome sequence of the alkaliphilic Bacillus clausii KSM-
RT K16.";
RL Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transcriptional factor involved in regulation of membrane
CC lipid biosynthesis by repressing genes involved in fatty acid and
CC phospholipid metabolism. {ECO:0000255|HAMAP-Rule:MF_01814}.
CC -!- SIMILARITY: Belongs to the FapR family. {ECO:0000255|HAMAP-
CC Rule:MF_01814}.
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DR EMBL; AP006627; BAD64839.1; -; Genomic_DNA.
DR RefSeq; WP_011247147.1; NC_006582.1.
DR AlphaFoldDB; Q5WFM1; -.
DR SMR; Q5WFM1; -.
DR STRING; 66692.ABC2304; -.
DR EnsemblBacteria; BAD64839; BAD64839; ABC2304.
DR KEGG; bcl:ABC2304; -.
DR eggNOG; COG1349; Bacteria.
DR HOGENOM; CLU_095708_0_0_9; -.
DR OMA; GIARGHH; -.
DR OrthoDB; 1813646at2; -.
DR Proteomes; UP000001168; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0045717; P:negative regulation of fatty acid biosynthetic process; IEA:UniProtKB-UniRule.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.10.10; -; 1.
DR HAMAP; MF_01814; Transcrip_fact_FapR; 1.
DR InterPro; IPR029069; HotDog_dom_sf.
DR InterPro; IPR002539; MaoC-like_dom.
DR InterPro; IPR017275; Transcription_factor_FapR.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR Pfam; PF01575; MaoC_dehydratas; 1.
DR PIRSF; PIRSF037733; Transcription_factor_FapR; 1.
DR SUPFAM; SSF54637; SSF54637; 1.
PE 3: Inferred from homology;
KW DNA-binding; Fatty acid biosynthesis; Fatty acid metabolism;
KW Lipid biosynthesis; Lipid metabolism; Reference proteome; Repressor;
KW Transcription; Transcription regulation.
FT CHAIN 1..191
FT /note="Transcription factor FapR"
FT /id="PRO_0000172816"
FT DOMAIN 102..169
FT /note="MaoC-like"
SQ SEQUENCE 191 AA; 21689 MW; E81BF0FA5789A2CC CRC64;
MKIKKKERQR LLMELLEGNP FMTDEELSAH FGVSIQTIRL DRMEQNIPEL RERIKDVAYK
QRDSVIALAP EEVFGEIVDL VLEERAISIF DVGPEHVFER SGIARGHHLF AQANSLAVAL
VNNEFVLTAK ASIQFTRPVR VGERVVAKAE MAGKGSGRTR ILVTSHVNQE VVFTGEFAMY
QQNETEERPQ Q