FAPR_BACAN
ID FAPR_BACAN Reviewed; 197 AA.
AC Q81WI4; Q6HUN2; Q6KJ16;
DT 15-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 25-MAY-2022, entry version 123.
DE RecName: Full=Transcription factor FapR {ECO:0000255|HAMAP-Rule:MF_01814};
DE AltName: Full=Fatty acid and phospholipid biosynthesis regulator {ECO:0000255|HAMAP-Rule:MF_01814};
GN Name=fapR {ECO:0000255|HAMAP-Rule:MF_01814};
GN OrderedLocusNames=BA_3992, GBAA_3992, BAS3705;
OS Bacillus anthracis.
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC Bacillus cereus group.
OX NCBI_TaxID=1392;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ames / isolate Porton;
RX PubMed=12721629; DOI=10.1038/nature01586;
RA Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T.,
RA Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R.,
RA Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M.,
RA Kolonay J.F., Beanan M.J., Dodson R.J., Brinkac L.M., Gwinn M.L.,
RA DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C.,
RA Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y.,
RA Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M.,
RA Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E.,
RA White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M.,
RA Hanna P.C., Kolstoe A.-B., Fraser C.M.;
RT "The genome sequence of Bacillus anthracis Ames and comparison to closely
RT related bacteria.";
RL Nature 423:81-86(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ames ancestor;
RX PubMed=18952800; DOI=10.1128/jb.01347-08;
RA Ravel J., Jiang L., Stanley S.T., Wilson M.R., Decker R.S., Read T.D.,
RA Worsham P., Keim P.S., Salzberg S.L., Fraser-Liggett C.M., Rasko D.A.;
RT "The complete genome sequence of Bacillus anthracis Ames 'Ancestor'.";
RL J. Bacteriol. 191:445-446(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Sterne;
RA Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K.,
RA Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R.,
RA Richardson P., Rubin E., Tice H.;
RT "Complete genome sequence of Bacillus anthracis Sterne.";
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transcriptional factor involved in regulation of membrane
CC lipid biosynthesis by repressing genes involved in fatty acid and
CC phospholipid metabolism. {ECO:0000255|HAMAP-Rule:MF_01814}.
CC -!- SIMILARITY: Belongs to the FapR family. {ECO:0000255|HAMAP-
CC Rule:MF_01814}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAT56007.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AE016879; AAP27720.1; -; Genomic_DNA.
DR EMBL; AE017334; AAT35401.1; -; Genomic_DNA.
DR EMBL; AE017225; AAT56007.1; ALT_INIT; Genomic_DNA.
DR RefSeq; NP_846234.1; NC_003997.3.
DR RefSeq; WP_000747352.1; NZ_WXXJ01000026.1.
DR AlphaFoldDB; Q81WI4; -.
DR SMR; Q81WI4; -.
DR STRING; 260799.BAS3705; -.
DR DNASU; 1087536; -.
DR EnsemblBacteria; AAP27720; AAP27720; BA_3992.
DR EnsemblBacteria; AAT35401; AAT35401; GBAA_3992.
DR GeneID; 59155649; -.
DR GeneID; 64199193; -.
DR KEGG; ban:BA_3992; -.
DR KEGG; bar:GBAA_3992; -.
DR KEGG; bat:BAS3705; -.
DR PATRIC; fig|198094.11.peg.3962; -.
DR eggNOG; COG1349; Bacteria.
DR eggNOG; COG2050; Bacteria.
DR HOGENOM; CLU_095708_0_0_9; -.
DR OMA; GIARGHH; -.
DR Proteomes; UP000000427; Chromosome.
DR Proteomes; UP000000594; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0045717; P:negative regulation of fatty acid biosynthetic process; IEA:UniProtKB-UniRule.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.10.10; -; 1.
DR HAMAP; MF_01814; Transcrip_fact_FapR; 1.
DR InterPro; IPR029069; HotDog_dom_sf.
DR InterPro; IPR006683; Thioestr_dom.
DR InterPro; IPR017275; Transcription_factor_FapR.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF03061; 4HBT; 1.
DR PIRSF; PIRSF037733; Transcription_factor_FapR; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR SUPFAM; SSF54637; SSF54637; 1.
PE 3: Inferred from homology;
KW DNA-binding; Fatty acid biosynthesis; Fatty acid metabolism;
KW Lipid biosynthesis; Lipid metabolism; Reference proteome; Repressor;
KW Transcription; Transcription regulation.
FT CHAIN 1..197
FT /note="Transcription factor FapR"
FT /id="PRO_0000172812"
SQ SEQUENCE 197 AA; 22782 MW; 0A2E17E32E213842 CRC64;
MKKRRSKKER QELLQQTIET NPFITDEDLA EKFQVSIQTV RLDRMELSIP ELRERIKHVA
TKQHEEDVKS LPLEEVVGEI IDIELDRHAI SIFEVKVEHV FKRNQIARGH HLFAQANSLA
VAVIDEELAL TAKSTIRYIR PVKLGERVVA KARVEDVEND KGRTVVKVRS FVGEELVFTG
TFEMYRSSNY SEEGNNL
