FAPR_BACC7
ID FAPR_BACC7 Reviewed; 197 AA.
AC B7HLI7;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 10-FEB-2009, sequence version 1.
DT 25-MAY-2022, entry version 74.
DE RecName: Full=Transcription factor FapR {ECO:0000255|HAMAP-Rule:MF_01814};
DE AltName: Full=Fatty acid and phospholipid biosynthesis regulator {ECO:0000255|HAMAP-Rule:MF_01814};
GN Name=fapR {ECO:0000255|HAMAP-Rule:MF_01814};
GN OrderedLocusNames=BCAH187_A3902;
OS Bacillus cereus (strain AH187).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC Bacillus cereus group.
OX NCBI_TaxID=405534;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AH187;
RA Dodson R.J., Durkin A.S., Rosovitz M.J., Rasko D.A., Kolsto A.B.,
RA Okstad O.A., Ravel J., Sutton G.;
RT "Genome sequence of Bacillus cereus AH187.";
RL Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transcriptional factor involved in regulation of membrane
CC lipid biosynthesis by repressing genes involved in fatty acid and
CC phospholipid metabolism. {ECO:0000255|HAMAP-Rule:MF_01814}.
CC -!- SIMILARITY: Belongs to the FapR family. {ECO:0000255|HAMAP-
CC Rule:MF_01814}.
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DR EMBL; CP001177; ACJ78875.1; -; Genomic_DNA.
DR RefSeq; WP_000747352.1; NC_011658.1.
DR AlphaFoldDB; B7HLI7; -.
DR SMR; B7HLI7; -.
DR EnsemblBacteria; ACJ78875; ACJ78875; BCAH187_A3902.
DR GeneID; 59155649; -.
DR GeneID; 64199193; -.
DR KEGG; bcr:BCAH187_A3902; -.
DR HOGENOM; CLU_095708_0_0_9; -.
DR OMA; GIARGHH; -.
DR OrthoDB; 1813646at2; -.
DR Proteomes; UP000002214; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0045717; P:negative regulation of fatty acid biosynthetic process; IEA:UniProtKB-UniRule.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.10.10; -; 1.
DR HAMAP; MF_01814; Transcrip_fact_FapR; 1.
DR InterPro; IPR029069; HotDog_dom_sf.
DR InterPro; IPR006683; Thioestr_dom.
DR InterPro; IPR017275; Transcription_factor_FapR.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF03061; 4HBT; 1.
DR PIRSF; PIRSF037733; Transcription_factor_FapR; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR SUPFAM; SSF54637; SSF54637; 1.
PE 3: Inferred from homology;
KW DNA-binding; Fatty acid biosynthesis; Fatty acid metabolism;
KW Lipid biosynthesis; Lipid metabolism; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..197
FT /note="Transcription factor FapR"
FT /id="PRO_1000187832"
SQ SEQUENCE 197 AA; 22782 MW; 0A2E17E32E213842 CRC64;
MKKRRSKKER QELLQQTIET NPFITDEDLA EKFQVSIQTV RLDRMELSIP ELRERIKHVA
TKQHEEDVKS LPLEEVVGEI IDIELDRHAI SIFEVKVEHV FKRNQIARGH HLFAQANSLA
VAVIDEELAL TAKSTIRYIR PVKLGERVVA KARVEDVEND KGRTVVKVRS FVGEELVFTG
TFEMYRSSNY SEEGNNL