FAPR_BACHK
ID FAPR_BACHK Reviewed; 197 AA.
AC Q6HEW1;
DT 21-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 2.
DT 25-MAY-2022, entry version 101.
DE RecName: Full=Transcription factor FapR {ECO:0000255|HAMAP-Rule:MF_01814};
DE AltName: Full=Fatty acid and phospholipid biosynthesis regulator {ECO:0000255|HAMAP-Rule:MF_01814};
GN Name=fapR {ECO:0000255|HAMAP-Rule:MF_01814}; OrderedLocusNames=BT9727_3595;
OS Bacillus thuringiensis subsp. konkukian (strain 97-27).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC Bacillus cereus group.
OX NCBI_TaxID=281309;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=97-27;
RX PubMed=16621833; DOI=10.1128/jb.188.9.3382-3390.2006;
RA Han C.S., Xie G., Challacombe J.F., Altherr M.R., Bhotika S.S., Bruce D.,
RA Campbell C.S., Campbell M.L., Chen J., Chertkov O., Cleland C.,
RA Dimitrijevic M., Doggett N.A., Fawcett J.J., Glavina T., Goodwin L.A.,
RA Hill K.K., Hitchcock P., Jackson P.J., Keim P., Kewalramani A.R.,
RA Longmire J., Lucas S., Malfatti S., McMurry K., Meincke L.J., Misra M.,
RA Moseman B.L., Mundt M., Munk A.C., Okinaka R.T., Parson-Quintana B.,
RA Reilly L.P., Richardson P., Robinson D.L., Rubin E., Saunders E., Tapia R.,
RA Tesmer J.G., Thayer N., Thompson L.S., Tice H., Ticknor L.O., Wills P.L.,
RA Brettin T.S., Gilna P.;
RT "Pathogenomic sequence analysis of Bacillus cereus and Bacillus
RT thuringiensis isolates closely related to Bacillus anthracis.";
RL J. Bacteriol. 188:3382-3390(2006).
CC -!- FUNCTION: Transcriptional factor involved in regulation of membrane
CC lipid biosynthesis by repressing genes involved in fatty acid and
CC phospholipid metabolism. {ECO:0000255|HAMAP-Rule:MF_01814}.
CC -!- SIMILARITY: Belongs to the FapR family. {ECO:0000255|HAMAP-
CC Rule:MF_01814}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAT60620.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AE017355; AAT60620.1; ALT_INIT; Genomic_DNA.
DR RefSeq; WP_000747352.1; NC_005957.1.
DR RefSeq; YP_037915.1; NC_005957.1.
DR AlphaFoldDB; Q6HEW1; -.
DR SMR; Q6HEW1; -.
DR EnsemblBacteria; AAT60620; AAT60620; BT9727_3595.
DR GeneID; 59155649; -.
DR GeneID; 64199193; -.
DR KEGG; btk:BT9727_3595; -.
DR PATRIC; fig|281309.8.peg.3833; -.
DR HOGENOM; CLU_095708_0_0_9; -.
DR OMA; GIARGHH; -.
DR Proteomes; UP000001301; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0045717; P:negative regulation of fatty acid biosynthetic process; IEA:UniProtKB-UniRule.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.10.10; -; 1.
DR HAMAP; MF_01814; Transcrip_fact_FapR; 1.
DR InterPro; IPR029069; HotDog_dom_sf.
DR InterPro; IPR006683; Thioestr_dom.
DR InterPro; IPR017275; Transcription_factor_FapR.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF03061; 4HBT; 1.
DR PIRSF; PIRSF037733; Transcription_factor_FapR; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR SUPFAM; SSF54637; SSF54637; 1.
PE 3: Inferred from homology;
KW DNA-binding; Fatty acid biosynthesis; Fatty acid metabolism;
KW Lipid biosynthesis; Lipid metabolism; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..197
FT /note="Transcription factor FapR"
FT /id="PRO_0000172820"
SQ SEQUENCE 197 AA; 22782 MW; 0A2E17E32E213842 CRC64;
MKKRRSKKER QELLQQTIET NPFITDEDLA EKFQVSIQTV RLDRMELSIP ELRERIKHVA
TKQHEEDVKS LPLEEVVGEI IDIELDRHAI SIFEVKVEHV FKRNQIARGH HLFAQANSLA
VAVIDEELAL TAKSTIRYIR PVKLGERVVA KARVEDVEND KGRTVVKVRS FVGEELVFTG
TFEMYRSSNY SEEGNNL