ID   FAPR_BACMK              Reviewed;         197 AA.
AC   A9VT92;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Transcription factor FapR {ECO:0000255|HAMAP-Rule:MF_01814};
DE   AltName: Full=Fatty acid and phospholipid biosynthesis regulator {ECO:0000255|HAMAP-Rule:MF_01814};
GN   Name=fapR {ECO:0000255|HAMAP-Rule:MF_01814};
GN   OrderedLocusNames=BcerKBAB4_3677;
OS   Bacillus mycoides (strain KBAB4) (Bacillus weihenstephanensis).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus cereus group.
OX   NCBI_TaxID=315730;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KBAB4;
RX   PubMed=17434157; DOI=10.1016/j.cbi.2007.03.003;
RA   Lapidus A., Goltsman E., Auger S., Galleron N., Segurens B., Dossat C.,
RA   Land M.L., Broussolle V., Brillard J., Guinebretiere M.-H., Sanchis V.,
RA   Nguen-the C., Lereclus D., Richardson P., Wincker P., Weissenbach J.,
RA   Ehrlich S.D., Sorokin A.;
RT   "Extending the Bacillus cereus group genomics to putative food-borne
RT   pathogens of different toxicity.";
RL   Chem. Biol. Interact. 171:236-249(2008).
CC   -!- FUNCTION: Transcriptional factor involved in regulation of membrane
CC       lipid biosynthesis by repressing genes involved in fatty acid and
CC       phospholipid metabolism. {ECO:0000255|HAMAP-Rule:MF_01814}.
CC   -!- SIMILARITY: Belongs to the FapR family. {ECO:0000255|HAMAP-
CC       Rule:MF_01814}.
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DR   EMBL; CP000903; ABY44848.1; -; Genomic_DNA.
DR   RefSeq; WP_000747354.1; NC_010184.1.
DR   AlphaFoldDB; A9VT92; -.
DR   SMR; A9VT92; -.
DR   STRING; 315730.BcerKBAB4_3677; -.
DR   EnsemblBacteria; ABY44848; ABY44848; BcerKBAB4_3677.
DR   GeneID; 66266582; -.
DR   KEGG; bwe:BcerKBAB4_3677; -.
DR   eggNOG; COG1349; Bacteria.
DR   eggNOG; COG2050; Bacteria.
DR   HOGENOM; CLU_095708_0_0_9; -.
DR   OMA; GIARGHH; -.
DR   Proteomes; UP000002154; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0045717; P:negative regulation of fatty acid biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   HAMAP; MF_01814; Transcrip_fact_FapR; 1.
DR   InterPro; IPR029069; HotDog_dom_sf.
DR   InterPro; IPR006683; Thioestr_dom.
DR   InterPro; IPR017275; Transcription_factor_FapR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF03061; 4HBT; 1.
DR   PIRSF; PIRSF037733; Transcription_factor_FapR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF54637; SSF54637; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Fatty acid biosynthesis; Fatty acid metabolism;
KW   Lipid biosynthesis; Lipid metabolism; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..197
FT                   /note="Transcription factor FapR"
FT                   /id="PRO_1000187833"
SQ   SEQUENCE   197 AA;  22810 MW;  287E17E32E329AC8 CRC64;
     MKKRRSKKER QELLQQTIET NPFITDEDLA EKFQVSIQTV RLDRMELSIP ELRERIKHVA
     TKQHEEDVKS LPLEEVVGEI IDIELDRHAI SIFEVKVEHV FKRNQIARGH HLFAQANSLA
     VAVIDEELAL TAKSTIRYIR PVKLGERVVA KVRVEDVEND KGRTVVKVRS FVGEELVFTG
     TFEMYRSSNY SEEGNNL