ID   FAPR_ECOLX              Reviewed;         260 AA.
AC   P23774;
DT   01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 2.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=987P fimbrial operon positive regulatory protein FapR;
GN   Name=fapR;
OS   Escherichia coli.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=562;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2077360; DOI=10.1111/j.1365-2958.1990.tb00556.x;
RA   Klaasen P., de Graaf F.K.;
RT   "Characterization of FapR, a positive regulator of expression of the 987P
RT   operon in enterotoxigenic Escherichia coli.";
RL   Mol. Microbiol. 4:1779-1783(1990).
CC   -!- FUNCTION: Positive regulator of the expression of the 987P operon for
CC       the fimbrial protein in enterotoxygenic E.coli.
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DR   EMBL; X53494; CAA37578.1; -; Genomic_DNA.
DR   PIR; S11984; S11984.
DR   RefSeq; WP_063079408.1; NZ_LVMU01000253.1.
DR   AlphaFoldDB; P23774; -.
DR   SMR; P23774; -.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR018060; HTH_AraC.
DR   InterPro; IPR018062; HTH_AraC-typ_CS.
DR   InterPro; IPR020449; Tscrpt_reg_HTH_AraC-type.
DR   Pfam; PF12833; HTH_18; 1.
DR   PRINTS; PR00032; HTHARAC.
DR   SMART; SM00342; HTH_ARAC; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00041; HTH_ARAC_FAMILY_1; 1.
DR   PROSITE; PS01124; HTH_ARAC_FAMILY_2; 1.
PE   4: Predicted;
KW   Activator; DNA-binding; Transcription; Transcription regulation.
FT   CHAIN           1..260
FT                   /note="987P fimbrial operon positive regulatory protein
FT                   FapR"
FT                   /id="PRO_0000194512"
FT   DOMAIN          154..251
FT                   /note="HTH araC/xylS-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   DNA_BIND        171..192
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   DNA_BIND        218..241
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
SQ   SEQUENCE   260 AA;  30349 MW;  1F73401737062C7A CRC64;
     MKLKNIHLYN YVVIYTKNCE IYINKGNEQV YIPPRMVAIF EKNISFNIET IRKGDGVLYE
     SFDMKHELLT SLRRVIEPSV KFAAESYTNK RSFKERIFKV KSCSIVIDLF KRLKDNGSPE
     FTAIYELAFL VSKCENPSMF AISLFSSVAV TFSERIVTLL FSDLTRKWKL SDIAEEMHIS
     EISVRKRLEQ ECLNFNQLIL DVRMNQAAKF IIRSDHQIGM IASLVGYTSV SYFIKTFKEY
     YGVTPKKFEI GIKENLRCNR