ID   FAPR_STAAC              Reviewed;         185 AA.
AC   Q5HGK5;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 2.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Transcription factor FapR {ECO:0000255|HAMAP-Rule:MF_01814};
DE   AltName: Full=Fatty acid and phospholipid biosynthesis regulator {ECO:0000255|HAMAP-Rule:MF_01814};
GN   Name=fapR {ECO:0000255|HAMAP-Rule:MF_01814}; OrderedLocusNames=SACOL1242;
OS   Staphylococcus aureus (strain COL).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=93062;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=COL;
RX   PubMed=15774886; DOI=10.1128/jb.187.7.2426-2438.2005;
RA   Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J.,
RA   Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J.,
RA   Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H.,
RA   Vamathevan J.J., Khouri H., Utterback T.R., Lee C., Dimitrov G., Jiang L.,
RA   Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E.,
RA   Fraser C.M.;
RT   "Insights on evolution of virulence and resistance from the complete genome
RT   analysis of an early methicillin-resistant Staphylococcus aureus strain and
RT   a biofilm-producing methicillin-resistant Staphylococcus epidermidis
RT   strain.";
RL   J. Bacteriol. 187:2426-2438(2005).
CC   -!- FUNCTION: Transcriptional factor involved in regulation of membrane
CC       lipid biosynthesis by repressing genes involved in fatty acid and
CC       phospholipid metabolism. {ECO:0000255|HAMAP-Rule:MF_01814}.
CC   -!- SIMILARITY: Belongs to the FapR family. {ECO:0000255|HAMAP-
CC       Rule:MF_01814}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAW38076.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CP000046; AAW38076.1; ALT_INIT; Genomic_DNA.
DR   AlphaFoldDB; Q5HGK5; -.
DR   SMR; Q5HGK5; -.
DR   EnsemblBacteria; AAW38076; AAW38076; SACOL1242.
DR   KEGG; sac:SACOL1242; -.
DR   HOGENOM; CLU_095708_0_0_9; -.
DR   Proteomes; UP000000530; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0045717; P:negative regulation of fatty acid biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   HAMAP; MF_01814; Transcrip_fact_FapR; 1.
DR   InterPro; IPR029069; HotDog_dom_sf.
DR   InterPro; IPR006683; Thioestr_dom.
DR   InterPro; IPR017275; Transcription_factor_FapR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   Pfam; PF03061; 4HBT; 1.
DR   PIRSF; PIRSF037733; Transcription_factor_FapR; 1.
DR   SUPFAM; SSF54637; SSF54637; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Fatty acid biosynthesis; Fatty acid metabolism;
KW   Lipid biosynthesis; Lipid metabolism; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..185
FT                   /note="Transcription factor FapR"
FT                   /id="PRO_0000172827"
SQ   SEQUENCE   185 AA;  21434 MW;  F779DCC3C4D94E0F CRC64;
     MKLKKDKRRE AIRQQIDSNP FITDHELSDL FQVSIQTIRL DRTYLNIPEL RKRIKLVAEK
     NYDQISSIEE QEFIGDLIQV NPNVKAQSIL DITSDSVFHK TGIARGHVLF AQANSLCVAL
     IKQPTVLTHE SSIQFIEKVK LNDTVRAEAR VVNQTAKHYY VEVKSYVKHT LVFKGNFKMF
     YDKRG