ID   FAPR_STAES              Reviewed;         186 AA.
AC   Q8CSV2;
DT   15-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT   15-AUG-2003, sequence version 2.
DT   25-MAY-2022, entry version 107.
DE   RecName: Full=Transcription factor FapR {ECO:0000255|HAMAP-Rule:MF_01814};
DE   AltName: Full=Fatty acid and phospholipid biosynthesis regulator {ECO:0000255|HAMAP-Rule:MF_01814};
GN   Name=fapR {ECO:0000255|HAMAP-Rule:MF_01814}; OrderedLocusNames=SE_0903;
OS   Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=176280;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 12228 / FDA PCI 1200;
RX   PubMed=12950922; DOI=10.1046/j.1365-2958.2003.03671.x;
RA   Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q.,
RA   Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H.,
RA   Zhao G.-P., Qu D., Danchin A., Wen Y.-M.;
RT   "Genome-based analysis of virulence genes in a non-biofilm-forming
RT   Staphylococcus epidermidis strain (ATCC 12228).";
RL   Mol. Microbiol. 49:1577-1593(2003).
CC   -!- FUNCTION: Transcriptional factor involved in regulation of membrane
CC       lipid biosynthesis by repressing genes involved in fatty acid and
CC       phospholipid metabolism. {ECO:0000255|HAMAP-Rule:MF_01814}.
CC   -!- SIMILARITY: Belongs to the FapR family. {ECO:0000255|HAMAP-
CC       Rule:MF_01814}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAO04500.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE015929; AAO04500.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; NP_764458.1; NC_004461.1.
DR   RefSeq; WP_001830099.1; NC_004461.1.
DR   AlphaFoldDB; Q8CSV2; -.
DR   SMR; Q8CSV2; -.
DR   STRING; 176280.SE_0903; -.
DR   EnsemblBacteria; AAO04500; AAO04500; SE_0903.
DR   GeneID; 50018959; -.
DR   KEGG; sep:SE_0903; -.
DR   PATRIC; fig|176280.10.peg.876; -.
DR   eggNOG; COG1349; Bacteria.
DR   HOGENOM; CLU_095708_0_0_9; -.
DR   Proteomes; UP000001411; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0045717; P:negative regulation of fatty acid biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   HAMAP; MF_01814; Transcrip_fact_FapR; 1.
DR   InterPro; IPR029069; HotDog_dom_sf.
DR   InterPro; IPR017275; Transcription_factor_FapR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PIRSF; PIRSF037733; Transcription_factor_FapR; 1.
DR   SUPFAM; SSF54637; SSF54637; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Fatty acid biosynthesis; Fatty acid metabolism;
KW   Lipid biosynthesis; Lipid metabolism; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..186
FT                   /note="Transcription factor FapR"
FT                   /id="PRO_0000172833"
SQ   SEQUENCE   186 AA;  21421 MW;  E817002658A461AE CRC64;
     MKLKKNDRRV AIKEAIELNP FITDYELCEK FDVSIQTIRL DRTHLNIPEL RKRIKLVAEQ
     NYGRIKSIEA NEIIGDLIQV NPDVSAQSLI EITIDSVFAK SEIARGHVLF AQANSLCVAL
     IHKPIVLTHE SQVEFKEKVK LNDTVRADAR VIDITDKHYI IEVNSYVSDM LVFKGKFKMY
     YTSEDE