ID   FAPR_THEP3              Reviewed;         200 AA.
AC   B0K9Y3;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   18-MAR-2008, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Transcription factor FapR {ECO:0000255|HAMAP-Rule:MF_01814};
DE   AltName: Full=Fatty acid and phospholipid biosynthesis regulator {ECO:0000255|HAMAP-Rule:MF_01814};
GN   Name=fapR {ECO:0000255|HAMAP-Rule:MF_01814}; OrderedLocusNames=Teth39_1292;
OS   Thermoanaerobacter pseudethanolicus (strain ATCC 33223 / 39E) (Clostridium
OS   thermohydrosulfuricum).
OC   Bacteria; Firmicutes; Clostridia; Thermoanaerobacterales;
OC   Thermoanaerobacteraceae; Thermoanaerobacter.
OX   NCBI_TaxID=340099;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33223 / DSM 2355 / 39E;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Bruce D., Goodwin L., Saunders E., Brettin T.,
RA   Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L.,
RA   Kyrpides N., Lykidis A., Hemme C., Fields M.W., He Z., Zhou J.,
RA   Richardson P.;
RT   "Complete sequence of Thermoanaerobacter pseudethanolicus 39E.";
RL   Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcriptional factor involved in regulation of membrane
CC       lipid biosynthesis by repressing genes involved in fatty acid and
CC       phospholipid metabolism. {ECO:0000255|HAMAP-Rule:MF_01814}.
CC   -!- SIMILARITY: Belongs to the FapR family. {ECO:0000255|HAMAP-
CC       Rule:MF_01814}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000924; ABY94946.1; -; Genomic_DNA.
DR   RefSeq; WP_003869201.1; NC_010321.1.
DR   AlphaFoldDB; B0K9Y3; -.
DR   SMR; B0K9Y3; -.
DR   STRING; 340099.Teth39_1292; -.
DR   EnsemblBacteria; ABY94946; ABY94946; Teth39_1292.
DR   KEGG; tpd:Teth39_1292; -.
DR   eggNOG; COG2030; Bacteria.
DR   HOGENOM; CLU_095708_0_0_9; -.
DR   OMA; GIARGHH; -.
DR   Proteomes; UP000002156; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0045717; P:negative regulation of fatty acid biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   HAMAP; MF_01814; Transcrip_fact_FapR; 1.
DR   InterPro; IPR029069; HotDog_dom_sf.
DR   InterPro; IPR017275; Transcription_factor_FapR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PIRSF; PIRSF037733; Transcription_factor_FapR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF54637; SSF54637; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Fatty acid biosynthesis; Fatty acid metabolism;
KW   Lipid biosynthesis; Lipid metabolism; Reference proteome; Repressor;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..200
FT                   /note="Transcription factor FapR"
FT                   /id="PRO_1000187836"
SQ   SEQUENCE   200 AA;  22869 MW;  1D21417CE76B9126 CRC64;
     MAVRMSKVER QRLLKEKINT NPFYTDDELA EMFGVSVQTI RLDRMELGIP EVRERIKSVA
     EENYQKVRTI TGTEVVGELI DLELGKRGIS IFEPTEDMVF VKTKIVKGQY IYSQAESLAM
     SVIDASAALI GVANIKYKFP VKVGDRLVAK AEVIRQRGNK YFVWVKIKVK DKEVFRGKFI
     LVAIDEDFLK KRSDTVEVSN