ID   FAPR_THETC              Reviewed;         194 AA.
AC   O65983; D9TNN3;
DT   15-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=Transcription factor FapR;
DE   AltName: Full=Fatty acid and phospholipid biosynthesis regulator;
GN   Name=fapR; OrderedLocusNames=Tthe_1498;
OS   Thermoanaerobacterium thermosaccharolyticum (strain ATCC 7956 / DSM 571 /
OS   NCIMB 9385 / NCA 3814 / NCTC 13789 / WDCM 00135 / 2032) (Clostridium
OS   thermosaccharolyticum).
OC   Bacteria; Firmicutes; Clostridia; Thermoanaerobacterales;
OC   Thermoanaerobacterales Family III. Incertae Sedis; Thermoanaerobacterium.
OX   NCBI_TaxID=580327;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 7956 / DSM 571 / NCIMB 9385 / NCA 3814 / NCTC 13789 / WDCM
RC   00135 / 2032;
RA   Van Rinsum A.;
RL   Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 7956 / DSM 571 / NCIMB 9385 / NCA 3814 / NCTC 13789 / WDCM
RC   00135 / 2032;
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA   Pitluck S., Teshima H., Detter J.C., Han C., Tapia R., Land M., Hauser L.,
RA   Chang Y.-J., Jeffries C., Kyrpides N., Ivanova N., Mikhailova N.,
RA   Hemme C.L., Woyke T.;
RT   "Complete sequence of Thermoanaerobacterium thermosaccharolyticum DSM
RT   571.";
RL   Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcriptional factor involved in regulation of membrane
CC       lipid biosynthesis by repressing genes involved in fatty acid and
CC       phospholipid metabolism. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the FapR family. {ECO:0000305}.
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DR   EMBL; AJ004870; CAA06177.1; -; Genomic_DNA.
DR   EMBL; CP002171; ADL69008.1; -; Genomic_DNA.
DR   RefSeq; WP_013297975.1; NC_014410.1.
DR   AlphaFoldDB; O65983; -.
DR   SMR; O65983; -.
DR   STRING; 580327.Tthe_1498; -.
DR   EnsemblBacteria; ADL69008; ADL69008; Tthe_1498.
DR   KEGG; ttm:Tthe_1498; -.
DR   eggNOG; COG2030; Bacteria.
DR   HOGENOM; CLU_095708_0_0_9; -.
DR   OMA; GIARGHH; -.
DR   OrthoDB; 1813646at2; -.
DR   Proteomes; UP000001626; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0045717; P:negative regulation of fatty acid biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   HAMAP; MF_01814; Transcrip_fact_FapR; 1.
DR   InterPro; IPR029069; HotDog_dom_sf.
DR   InterPro; IPR017275; Transcription_factor_FapR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PIRSF; PIRSF037733; Transcription_factor_FapR; 1.
DR   SUPFAM; SSF54637; SSF54637; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Fatty acid biosynthesis; Fatty acid metabolism;
KW   Lipid biosynthesis; Lipid metabolism; Reference proteome; Repressor;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..194
FT                   /note="Transcription factor FapR"
FT                   /id="PRO_0000172821"
SQ   SEQUENCE   194 AA;  22172 MW;  1150BBC68BB3838C CRC64;
     MATKLNKKDR LRQLKIEIDK NPFYTDDELA ELFSVSVQTI RLDRMELGIP ELRERIKNVA
     EENYHKVKAI VGSEIVGELI DLELGKSGIS VFEPTPDMAF LKTKIIRGHY IYSQAESLAI
     SVIDAEAALI GVANIKYKYP VRIGDRLVAK AEVIRKRGNK YFVWVMIKVK NKEVFRGKFI
     LASLESDNTE KEVQ