FAR10_YEAST
ID FAR10_YEAST Reviewed; 478 AA.
AC Q06001; D6VYN6;
DT 26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Factor arrest protein 10;
GN Name=FAR10; OrderedLocusNames=YLR238W;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169871;
RA Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W.,
RA Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A.,
RA Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K.,
RA Heuss-Neitzel D., Hilbert H., Hilger F., Kleine K., Koetter P., Louis E.J.,
RA Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S.,
RA Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D.,
RA Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M.,
RA Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P.,
RA Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M.,
RA Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K.,
RA Zollner A., Hani J., Hoheisel J.D.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.";
RL Nature 387:87-90(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP SUBCELLULAR LOCATION.
RX PubMed=12514182; DOI=10.1074/jbc.m212725200;
RA Beilharz T., Egan B., Silver P.A., Hofmann K., Lithgow T.;
RT "Bipartite signals mediate subcellular targeting of tail-anchored membrane
RT proteins in Saccharomyces cerevisiae.";
RL J. Biol. Chem. 278:8219-8223(2003).
RN [4]
RP FUNCTION, AND INTERACTION WITH FAR3; FAR7; FAR8; FAR11 AND VPS64.
RX PubMed=12588993; DOI=10.1128/mcb.23.5.1750-1763.2003;
RA Kemp H.A., Sprague G.F. Jr.;
RT "Far3 and five interacting proteins prevent premature recovery from
RT pheromone arrest in the budding yeast Saccharomyces cerevisiae.";
RL Mol. Cell. Biol. 23:1750-1763(2003).
CC -!- FUNCTION: Participates in the control of the reentry into the cell
CC cycle following pheromone treatment. {ECO:0000269|PubMed:12588993}.
CC -!- SUBUNIT: Component of a complex at least composed of FAR3, FAR7, FAR8,
CC FAR10, FAR11 and VPS64.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type IV
CC membrane protein {ECO:0000305}.
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DR EMBL; U19027; AAB67404.1; -; Genomic_DNA.
DR EMBL; BK006945; DAA09552.1; -; Genomic_DNA.
DR PIR; S51457; S51457.
DR RefSeq; NP_013339.1; NM_001182125.1.
DR AlphaFoldDB; Q06001; -.
DR SMR; Q06001; -.
DR BioGRID; 31505; 219.
DR ComplexPortal; CPX-1197; FAR complex.
DR DIP; DIP-1572N; -.
DR IntAct; Q06001; 12.
DR MINT; Q06001; -.
DR STRING; 4932.YLR238W; -.
DR iPTMnet; Q06001; -.
DR MaxQB; Q06001; -.
DR PaxDb; Q06001; -.
DR PRIDE; Q06001; -.
DR EnsemblFungi; YLR238W_mRNA; YLR238W; YLR238W.
DR GeneID; 850939; -.
DR KEGG; sce:YLR238W; -.
DR SGD; S000004228; FAR10.
DR VEuPathDB; FungiDB:YLR238W; -.
DR eggNOG; KOG3872; Eukaryota.
DR GeneTree; ENSGT00940000176673; -.
DR HOGENOM; CLU_031992_1_0_1; -.
DR InParanoid; Q06001; -.
DR OMA; HMAASNA; -.
DR BioCyc; YEAST:G3O-32347-MON; -.
DR PRO; PR:Q06001; -.
DR Proteomes; UP000002311; Chromosome XII.
DR RNAct; Q06001; protein.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005783; C:endoplasmic reticulum; IDA:SGD.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IC:ComplexPortal.
DR GO; GO:0090443; C:FAR/SIN/STRIPAK complex; IC:ComplexPortal.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0071444; P:cellular response to pheromone; IC:ComplexPortal.
DR GO; GO:0000321; P:re-entry into mitotic cell cycle after pheromone arrest; IGI:SGD.
DR GO; GO:0051726; P:regulation of cell cycle; IC:ComplexPortal.
DR CDD; cd00060; FHA; 1.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR Pfam; PF00498; FHA; 1.
DR SMART; SM00240; FHA; 1.
DR SUPFAM; SSF49879; SSF49879; 1.
DR PROSITE; PS50006; FHA_DOMAIN; 1.
PE 1: Evidence at protein level;
KW Cell cycle; Coiled coil; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..478
FT /note="Factor arrest protein 10"
FT /id="PRO_0000087189"
FT TOPO_DOM 1..454
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 455..475
FT /note="Helical; Anchor for type IV membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 476..478
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT DOMAIN 116..176
FT /note="FHA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00086"
FT REGION 1..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 101..129
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 405..443
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 342..426
FT /evidence="ECO:0000255"
FT COMPBIAS 18..41
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 104..122
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 405..431
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 478 AA; 54092 MW; A3A4B2B83C967DD0 CRC64;
MTGPGPEINK EEHPSSPGKK QITYNSIPKN ANLIDGSTNS SKRPIEKYDK RIADPTKSYF
PHSISRTPRR KYTYILVLTS LNGTFESKHV VIPFKPDGLK LGRPVANSNS SSSSSLRGGK
RVDSHTFSQV RSDNGNFDSR VLSRNHALLS CDPLTGKVYI RDLKSSNGTF INGQRIGSND
VEIKVGDVID LGTDIDTKIE HRKISATVEE LFVQPLLESP IFENEDSDDC HTITEKEEAA
AITSHIYGDS NNLELEEVIL GSDTEILSGI FINNCIGTSP TLSNIIKTLA MEIPFSKCDN
FKLQSMENFL INYTTHLEYT NKLLVEKNDQ QLVKLQNGLR RKLSGKYEKI IEQNRNQVKQ
LERDHMFFKK SFEVKKRRNN EKQKSMEREI EDLKTRLEVE RYKNSQMMKK NKQKEQELST
ASKKKTTEHD TRGVPGMNPK GTDKFSIKNT LCNHFTLLTF GTISIGIIAI VFKILSPN
