ID   FAR11_SCHPO             Reviewed;         817 AA.
AC   O13665;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=Factor arrest protein 11;
GN   Name=far11; ORFNames=pi074, SPBC27B12.04c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=10620777;
RX   DOI=10.1002/(sici)1097-0061(20000115)16:1<71::aid-yea505>3.0.co;2-5;
RA   Machida M., Yamazaki S., Kunihiro S., Tanaka T., Kushida N., Jinno K.,
RA   Haikawa Y., Yamazaki J., Yamamoto S., Sekine M., Oguchi A., Nagai Y.,
RA   Sakai M., Aoki K., Ogura K., Kudoh Y., Kikuchi H., Zhang M.Q., Yanagida M.;
RT   "A 38 kb segment containing the cdc2 gene from the left arm of fission
RT   yeast chromosome II: sequence analysis and characterization of the genomic
RT   DNA and cDNAs encoded on the segment.";
RL   Yeast 16:71-80(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [3]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
RN   [4]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-500 AND THR-502, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY.
RX   PubMed=18257517; DOI=10.1021/pr7006335;
RA   Wilson-Grady J.T., Villen J., Gygi S.P.;
RT   "Phosphoproteome analysis of fission yeast.";
RL   J. Proteome Res. 7:1088-1097(2008).
CC   -!- FUNCTION: Participates in the control of the reentry into the cell
CC       cycle following pheromone treatment. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Vacuole {ECO:0000269|PubMed:16823372}.
CC   -!- SIMILARITY: Belongs to the FAR11 family. {ECO:0000305}.
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DR   EMBL; AB004539; BAA21456.1; -; Genomic_DNA.
DR   EMBL; CU329671; CAA16899.1; -; Genomic_DNA.
DR   PIR; T40028; T40028.
DR   RefSeq; NP_595536.1; NM_001021447.2.
DR   AlphaFoldDB; O13665; -.
DR   SMR; O13665; -.
DR   BioGRID; 277023; 5.
DR   STRING; 4896.SPBC27B12.04c.1; -.
DR   iPTMnet; O13665; -.
DR   MaxQB; O13665; -.
DR   PaxDb; O13665; -.
DR   PRIDE; O13665; -.
DR   EnsemblFungi; SPBC27B12.04c.1; SPBC27B12.04c.1:pep; SPBC27B12.04c.
DR   GeneID; 2540495; -.
DR   KEGG; spo:SPBC27B12.04c; -.
DR   PomBase; SPBC27B12.04c; far11.
DR   VEuPathDB; FungiDB:SPBC27B12.04c; -.
DR   eggNOG; KOG3680; Eukaryota.
DR   HOGENOM; CLU_003184_0_0_1; -.
DR   InParanoid; O13665; -.
DR   OMA; KPYSWRN; -.
DR   PhylomeDB; O13665; -.
DR   PRO; PR:O13665; -.
DR   Proteomes; UP000002485; Chromosome II.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0090443; C:FAR/SIN/STRIPAK complex; IDA:PomBase.
DR   GO; GO:0000324; C:fungal-type vacuole; HDA:PomBase.
DR   GO; GO:0044732; C:mitotic spindle pole body; EXP:PomBase.
DR   GO; GO:0005635; C:nuclear envelope; IDA:PomBase.
DR   GO; GO:0071957; C:old mitotic spindle pole body; IDA:PomBase.
DR   GO; GO:0061509; P:asymmetric protein localization to old mitotic spindle pole body; IMP:PomBase.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0007010; P:cytoskeleton organization; IBA:GO_Central.
DR   GO; GO:0031030; P:negative regulation of septation initiation signaling; IMP:PomBase.
DR   InterPro; IPR040185; Far11/STRP.
DR   InterPro; IPR021819; Far11/STRP_C.
DR   InterPro; IPR012486; Far11/STRP_N.
DR   PANTHER; PTHR13239; PTHR13239; 1.
DR   Pfam; PF11882; DUF3402; 2.
DR   Pfam; PF07923; N1221; 1.
DR   SMART; SM01293; DUF3402; 1.
DR   SMART; SM01292; N1221; 1.
PE   1: Evidence at protein level;
KW   Cell cycle; Phosphoprotein; Reference proteome; Vacuole.
FT   CHAIN           1..817
FT                   /note="Factor arrest protein 11"
FT                   /id="PRO_0000337251"
FT   MOD_RES         500
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000269|PubMed:18257517"
FT   MOD_RES         502
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000269|PubMed:18257517"
SQ   SEQUENCE   817 AA;  95093 MW;  533B25137CB32397 CRC64;
     MAATTASCIS FSQFQRLKKL IDSPASKHKP MEFKGTSKDD LEDDLNSFFD CEEELFLSAN
     KIFYSKLRVY QTVRHWSLKQ NWSSMSLDQK RNFILHCHHE LSSGELLRNS ALYSILYIAA
     GAYDSVGSFE EHVHSISENV YLLREFDIPK TVYSLFIEWN RTRKHSFLDN SRDEGFLNLL
     LSLMFFFLTL NNTDKTWIHS IRSLNPPVLP TLVKLFIDIT SDYQLNLDKV IHSSLKKLSF
     LIFKVCIRLW GSQSYLQEKK AGLAEVLNIS TSQQKPKTTA LDYEVFRHEM ATKFSSFADS
     YYPVPLDREQ AHILPTLNTD SFHKSSFISS TRLCSPENPS LLVNTAKTSK MSARREQFQT
     NQNLPFCFTP NLEKLTIPYS VTEAANVFQN KTKRTLAVEQ LLSERELLRR FTLQQRLVAD
     LHEFYNSVKG PAHSFETEDP VLKFVSQSYD DLFPYMDNFI QLAVQLFYHI SKKVNCLYVE
     AFSSSDAVLQ RIQDNAVVDS PTEELSEQAA RNRKSNVKIE YTEDFATGFA ISGEISHSIN
     NLEFVLYSLS SLFLMMLKWF RLSHVLRFER LAFLLYENHF LEIFNRHLTE GDCNRNTEKD
     VKCVRGGFFS YSSKMYKYDR VSIPVITRAS SSRNLLITMN CLRVLEKVCK YSNIRKEIIA
     RSNLHENLKK LLAIPHDKLR LYALKVLKLS VPFLGLKWKQ ANMSIITQIY LNCSLDLRDS
     WMFHENGSDT YRSAQLQETF LAILIRFYHI RLYGKKCKSL YQFCILEEMR LKKSIEELAA
     SNMMEYIPES LWSYSFERSD TGFFENEFAA MHINDIA