ID   FAR18_LUCCU             Reviewed;          12 AA.
AC   P85462; P85465;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-MAY-2009, sequence version 1.
DT   02-JUN-2021, entry version 12.
DE   RecName: Full=FMRFamide-18;
DE   AltName: Full=LucFMRFamide-18 {ECO:0000303|PubMed:18789334};
OS   Lucilia cuprina (Green bottle fly) (Australian sheep blowfly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Oestroidea;
OC   Calliphoridae; Luciliinae; Lucilia.
OX   NCBI_TaxID=7375;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, TISSUE SPECIFICITY, MASS SPECTROMETRY, AMIDATION AT
RP   PHE-12, AND VARIANT SER-6.
RC   STRAIN=Bangladesh {ECO:0000269|PubMed:18789334}, and
RC   Goondiwindi {ECO:0000269|PubMed:18789334};
RC   TISSUE=Dorsal ganglionic sheath {ECO:0000269|PubMed:18789334};
RX   PubMed=18789334; DOI=10.1016/j.ygcen.2008.08.006;
RA   Rahman M.M., Fromm B., Neupert S., Kreusch S., Predel R.;
RT   "Extended FMRFamides in dipteran insects: conservative expression in the
RT   neuroendocrine system is accompanied by rapid sequence evolution.";
RL   Gen. Comp. Endocrinol. 162:52-58(2009).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Detected in the thoracic perisympathetic organs in
CC       larvae, and the dorsal ganglionic sheath in adults (at protein level).
CC       {ECO:0000269|PubMed:18789334}.
CC   -!- MASS SPECTROMETRY: Mass=1401.7; Method=MALDI; Note=Strain Goondiwindi.;
CC       Evidence={ECO:0000269|PubMed:18789334};
CC   -!- MASS SPECTROMETRY: Mass=1417.72; Method=MALDI; Note=Strain Bangladesh.;
CC       Evidence={ECO:0000269|PubMed:18789334};
CC   -!- SIMILARITY: Belongs to the FARP (FMRFamide related peptide) family.
CC       {ECO:0000255}.
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Neuropeptide; Secreted.
FT   PEPTIDE         1..12
FT                   /note="FMRFamide-18"
FT                   /id="PRO_0000371759"
FT   MOD_RES         12
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000269|PubMed:18789334"
FT   VARIANT         6
FT                   /note="A -> S (in strain: Bangladesh)"
FT                   /evidence="ECO:0000269|PubMed:18789334"
SQ   SEQUENCE   12 AA;  1403 MW;  2DC45509C04AADC7 CRC64;
     TPPQPADNFI RF