FAR1_BRUPA
ID FAR1_BRUPA Reviewed; 178 AA.
AC Q8WT55;
DT 21-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT 21-JUN-2005, sequence version 2.
DT 25-MAY-2022, entry version 44.
DE RecName: Full=Fatty-acid and retinol-binding protein 1;
DE AltName: Full=Bp-FAR-1;
DE Flags: Precursor;
GN Name=far-1 {ECO:0000312|EMBL:AAL33793.1};
OS Brugia pahangi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX NCBI_TaxID=6280;
RN [1] {ECO:0000312|EMBL:AAL33793.1}
RP NUCLEOTIDE SEQUENCE [MRNA], AND LACK OF GLYCOSYLATION.
RX PubMed=12106870; DOI=10.1016/s0166-6851(02)00097-x;
RA Garofalo A., Klager S.L., Rowlinson M.C., Nirmalan N., Klion A.D.,
RA Allen J.E., Kennedy M.W., Bradley J.E.;
RT "The FAR proteins of filarial nematodes: secretion, glycosylation and lipid
RT binding characteristics.";
RL Mol. Biochem. Parasitol. 122:161-170(2002).
CC -!- FUNCTION: Binds retinol and different fatty acids. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q25619}.
CC -!- PTM: Not glycosylated. {ECO:0000269|PubMed:12106870}.
CC -!- SIMILARITY: Belongs to the fatty-acid and retinol-binding protein
CC (FARBP) family. {ECO:0000250|UniProtKB:Q25619, ECO:0000305}.
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DR EMBL; AY050257; AAL33793.1; -; mRNA.
DR AlphaFoldDB; Q8WT55; -.
DR SMR; Q8WT55; -.
DR STRING; 6280.Q8WT55; -.
DR Proteomes; UP000038020; Genome Assembly.
DR GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
DR GO; GO:0005504; F:fatty acid binding; ISS:UniProtKB.
DR GO; GO:0016918; F:retinal binding; IEA:UniProtKB-KW.
DR GO; GO:0019841; F:retinol binding; ISS:UniProtKB.
DR InterPro; IPR008632; Gp-FAR-1.
DR PANTHER; PTHR31418; PTHR31418; 1.
DR Pfam; PF05823; Gp-FAR-1; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Lipid-binding; Retinol-binding; Secreted; Signal; Vitamin A.
FT SIGNAL 1..16
FT /evidence="ECO:0000255"
FT CHAIN 17..178
FT /note="Fatty-acid and retinol-binding protein 1"
FT /evidence="ECO:0000255"
FT /id="PRO_0000008759"
FT COILED 67..89
FT /evidence="ECO:0000255"
FT COILED 130..153
FT /evidence="ECO:0000255"
SQ SEQUENCE 178 AA; 20355 MW; 64ECDF251CC3CB66 CRC64;
MYHRLILLAL VGTTMANVIP FSMNNIPEEY KEFIPEEVRN FYKDLTVEDK EILRELASKH
ATFANEDAAL EALKDKSDKL YKNAVELRNF VKAKIDSLKP DAKIFVDEII AKARSLRSDD
GHKLDTEKIK QAARDIIAKY QALSEETKEE LKVTFPAIAK IIGNEKLKRN ASTFLQKN