FAR1_CORAP
ID FAR1_CORAP Reviewed; 305 AA.
AC Q07981;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 25-MAY-2022, entry version 64.
DE RecName: Full=FMRFamide-related peptides type HF-4;
DE AltName: Full=HeptaFaRP;
DE Contains:
DE RecName: Full=NDPFLRFGKKSDPFLRF-amide;
DE Contains:
DE RecName: Full=FMRFamide-like;
DE Contains:
DE RecName: Full=ENNNGYIRF-amide;
DE Contains:
DE RecName: Full=NDPFLRF-amide;
DE Contains:
DE RecName: Full=QDPFLRI-amide;
DE Contains:
DE RecName: Full=QDPFLRF-amide;
DE Contains:
DE RecName: Full=KQDPFLRI-amide;
DE Contains:
DE RecName: Full=SEPYLRF-amide;
DE Contains:
DE RecName: Full=NDPYLRF-amide;
DE Flags: Precursor;
OS Cornu aspersum (Brown garden snail) (Helix aspersa).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Heterobranchia; Euthyneura; Panpulmonata; Eupulmonata; Stylommatophora;
OC Helicina; Helicoidea; Helicidae; Cornu; Cornu.
OX NCBI_TaxID=6535;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND AMIDATION AT PHE-36; PHE-47; PHE-66;
RP ILE-75; PHE-84; PHE-93; ILE-102; PHE-111; PHE-120; PHE-129; PHE-138;
RP PHE-147; PHE-156 AND PHE-165.
RC TISSUE=Ganglion;
RX PubMed=19912881; DOI=10.1016/1044-7431(92)90049-8;
RA Lutz E.M., Macdonald M., Hettle S., Price D.A., Cottrell G.A.,
RA Sommerville J.;
RT "Structure of cDNA clones and genomic DNA FMRFamide-related peptides
RT (FaRPs) in Helix.";
RL Mol. Cell. Neurosci. 3:373-382(1992).
RN [2]
RP PARTIAL PROTEIN SEQUENCE (QDPFLRF-AMIDE; NDPYLRF-AMIDE AND SEPYLRF-AMIDE).
RC TISSUE=Ganglion;
RX PubMed=1980513; DOI=10.1242/jeb.154.1.421;
RA Price D.A., Lesser W., Lee T.D., Doble K.E., Greenberg M.J.;
RT "Seven FMRFamide-related and two SCP-related cardioactive peptides from
RT Helix.";
RL J. Exp. Biol. 154:421-437(1990).
CC -!- FUNCTION: Can function as both cardioregulatory hormones and
CC transmitters and may regulate cardiovascular function.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Central nervous system.
CC -!- SIMILARITY: Belongs to the FARP (FMRFamide related peptide) family.
CC {ECO:0000305}.
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DR EMBL; X73333; CAA51760.1; -; mRNA.
DR PIR; S38817; S38817.
DR AlphaFoldDB; Q07981; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR InterPro; IPR002544; FMRFamid-related_peptide-like.
DR Pfam; PF01581; FARP; 16.
PE 1: Evidence at protein level;
KW Amidation; Direct protein sequencing; Neuropeptide; Repeat; Secreted;
KW Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT PEPTIDE 20..36
FT /note="FMRFamide-like"
FT /id="PRO_0000009567"
FT PEPTIDE 39..47
FT /note="ENNNGYIRF-amide"
FT /id="PRO_0000009568"
FT PEPTIDE 50..66
FT /note="NDPFLRFGKKSDPFLRF-amide"
FT /id="PRO_0000009569"
FT PEPTIDE 69..75
FT /note="QDPFLRI-amide"
FT /id="PRO_0000009570"
FT PEPTIDE 78..84
FT /note="QDPFLRF-amide"
FT /id="PRO_0000009571"
FT PEPTIDE 87..93
FT /note="QDPFLRF-amide"
FT /id="PRO_0000009572"
FT PEPTIDE 96..102
FT /note="KQDPFLRI-amide"
FT /id="PRO_0000009573"
FT PEPTIDE 105..111
FT /note="QDPFLRF-amide"
FT /id="PRO_0000009574"
FT PEPTIDE 114..120
FT /note="SEPYLRF-amide"
FT /id="PRO_0000009575"
FT PEPTIDE 123..129
FT /note="NDPYLRF-amide"
FT /id="PRO_0000009576"
FT PEPTIDE 132..138
FT /note="NDPYLRF-amide"
FT /id="PRO_0000009577"
FT PEPTIDE 141..147
FT /note="NDPYLRF-amide"
FT /id="PRO_0000009578"
FT PEPTIDE 150..156
FT /note="NDPYLRF-amide"
FT /id="PRO_0000009579"
FT PEPTIDE 159..165
FT /note="NDPFLRF-amide"
FT /id="PRO_0000009580"
FT PROPEP 168..305
FT /id="PRO_0000009581"
FT MOD_RES 36
FT /note="Phenylalanine amide"
FT /evidence="ECO:0000269|PubMed:19912881"
FT MOD_RES 47
FT /note="Phenylalanine amide"
FT /evidence="ECO:0000269|PubMed:19912881"
FT MOD_RES 66
FT /note="Phenylalanine amide"
FT /evidence="ECO:0000269|PubMed:19912881"
FT MOD_RES 75
FT /note="Isoleucine amide"
FT /evidence="ECO:0000269|PubMed:19912881"
FT MOD_RES 84
FT /note="Phenylalanine amide"
FT /evidence="ECO:0000269|PubMed:19912881"
FT MOD_RES 93
FT /note="Phenylalanine amide"
FT /evidence="ECO:0000269|PubMed:19912881"
FT MOD_RES 102
FT /note="Isoleucine amide"
FT /evidence="ECO:0000269|PubMed:19912881"
FT MOD_RES 111
FT /note="Phenylalanine amide"
FT /evidence="ECO:0000269|PubMed:19912881"
FT MOD_RES 120
FT /note="Phenylalanine amide"
FT /evidence="ECO:0000269|PubMed:19912881"
FT MOD_RES 129
FT /note="Phenylalanine amide"
FT /evidence="ECO:0000269|PubMed:19912881"
FT MOD_RES 138
FT /note="Phenylalanine amide"
FT /evidence="ECO:0000269|PubMed:19912881"
FT MOD_RES 147
FT /note="Phenylalanine amide"
FT /evidence="ECO:0000269|PubMed:19912881"
FT MOD_RES 156
FT /note="Phenylalanine amide"
FT /evidence="ECO:0000269|PubMed:19912881"
FT MOD_RES 165
FT /note="Phenylalanine amide"
FT /evidence="ECO:0000269|PubMed:19912881"
SQ SEQUENCE 305 AA; 35433 MW; 12240522124DA9F0 CRC64;
MTSLCLTIAP AVLSLICLSS YGWAEGDTTD NEYLRFGREN NNGYIRFGRN DPFLRFGKKS
DPFLRFGKQD PFLRIGRQDP FLRFGKQDPF LRFGKQDPFL RIGKQDPFLR FGRSEPYLRF
GRNDPYLRFG RNDPYLRFGR NDPYLRFGRN DPYLRFGKND PFLRFGKSVD GEIEAGVDAV
TLSREHEFAH ENAASDRQKR SAYTDAIDKD NSLTSLVREA REASDSNGQI NDGKVVEVPV
FRDTRNGHYM RFGKKNEVDV TDGDTYDRDY SDSDVSNLLR YYGNTVPLPA YDKRSEHKQE
YMRFG
