AIM24_YEAST
ID AIM24_YEAST Reviewed; 394 AA.
AC P47127; D6VWQ0;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Altered inheritance of mitochondria protein 24, mitochondrial;
DE AltName: Full=Found in mitochondrial proteome protein 26;
DE Flags: Precursor;
GN Name=AIM24; Synonyms=FMP26; OrderedLocusNames=YJR080C; ORFNames=J1847;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=8840504;
RX DOI=10.1002/(sici)1097-0061(199607)12:9<869::aid-yea964>3.0.co;2-1;
RA Huang M.-E., Manus V., Chuat J.-C., Galibert F.;
RT "Analysis of a 62 kb DNA sequence of chromosome X reveals 36 open reading
RT frames and a gene cluster with a counterpart on chromosome XI.";
RL Yeast 12:869-875(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=8641269; DOI=10.1002/j.1460-2075.1996.tb00557.x;
RA Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C.,
RA Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D.,
RA Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J.,
RA Heumann K., Hilger F., Hollenberg C.P., Huang M.-E., Jacq C.,
RA Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E.,
RA Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T.,
RA Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B.,
RA Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R.,
RA Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N.,
RA To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H.,
RA von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.;
RT "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X.";
RL EMBO J. 15:2031-2049(1996).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
RN [5]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [6]
RP DISRUPTION PHENOTYPE.
RX PubMed=19300474; DOI=10.1371/journal.pgen.1000407;
RA Hess D.C., Myers C.L., Huttenhower C., Hibbs M.A., Hayes A.P., Paw J.,
RA Clore J.J., Mendoza R.M., Luis B.S., Nislow C., Giaever G., Costanzo M.,
RA Troyanskaya O.G., Caudy A.A.;
RT "Computationally driven, quantitative experiments discover genes required
RT for mitochondrial biogenesis.";
RL PLoS Genet. 5:E1000407-E1000407(2009).
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:14562095}.
CC -!- DISRUPTION PHENOTYPE: Increases frequency of mitochondrial genome loss.
CC {ECO:0000269|PubMed:19300474}.
CC -!- MISCELLANEOUS: Present with 2290 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: Belongs to the AIM24 family. {ECO:0000305}.
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DR EMBL; Z49578; CAA89608.1; -; Genomic_DNA.
DR EMBL; L47993; AAB39304.1; -; Genomic_DNA.
DR EMBL; BK006943; DAA08866.1; -; Genomic_DNA.
DR PIR; S57099; S57099.
DR RefSeq; NP_012614.1; NM_001181738.1.
DR AlphaFoldDB; P47127; -.
DR BioGRID; 33836; 77.
DR DIP; DIP-5206N; -.
DR IntAct; P47127; 1.
DR STRING; 4932.YJR080C; -.
DR iPTMnet; P47127; -.
DR MaxQB; P47127; -.
DR PaxDb; P47127; -.
DR PRIDE; P47127; -.
DR EnsemblFungi; YJR080C_mRNA; YJR080C; YJR080C.
DR GeneID; 853543; -.
DR KEGG; sce:YJR080C; -.
DR SGD; S000003841; AIM24.
DR VEuPathDB; FungiDB:YJR080C; -.
DR eggNOG; ENOG502RXC5; Eukaryota.
DR HOGENOM; CLU_057912_0_0_1; -.
DR InParanoid; P47127; -.
DR OMA; NCIVKYE; -.
DR BioCyc; YEAST:G3O-31709-MON; -.
DR PRO; PR:P47127; -.
DR Proteomes; UP000002311; Chromosome X.
DR RNAct; P47127; protein.
DR GO; GO:0031305; C:integral component of mitochondrial inner membrane; IDA:SGD.
DR GO; GO:0005739; C:mitochondrion; HDA:SGD.
DR GO; GO:0007007; P:inner mitochondrial membrane organization; IMP:SGD.
DR Gene3D; 3.60.160.10; -; 1.
DR InterPro; IPR002838; AIM24.
DR InterPro; IPR036983; AIM24_sf.
DR Pfam; PF01987; AIM24; 1.
PE 1: Evidence at protein level;
KW Mitochondrion; Reference proteome; Transit peptide.
FT TRANSIT 1..111
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 112..394
FT /note="Altered inheritance of mitochondria protein 24,
FT mitochondrial"
FT /id="PRO_0000203103"
SQ SEQUENCE 394 AA; 44428 MW; 4359DD8A4C8AA230 CRC64;
MISPRVNTRV WQRSISLLSP QAAKTESNVV TKERTYIENL SKDIATSRFR LVDENGKIAS
ITVQPDIPIC IKKDCLVSIH NLNHLSLSYK WLNFWSNLIK FRSFKSSLFH RIIGSSVLEI
LAAPNFQTSR RPFDSSRSLS VLNLTGTKDW NVFGKDSIIA FEQNSSLEIK SPIFPSARSL
VSNSSKSQLP RKFQILNGRG NVLVCGGGLV YSIELIDESD KILVNSRNIL AINGQSQLDI
ANSVERQELH VEGAYVGDSS NDTVAPKFIK NQTLKSAYGH TVQFFKRMRS WIRNQYEKRY
IYGVDSYFMK IKGPRTILIQ THEMTTSKDN ILTKLTSKGH VKKSNVNDNG VNLEKQVAND
VNSKIIELAN RPSLFIATVS QDGRVDFQST SKFT
