ID   FAR1_LOALO              Reviewed;         178 AA.
AC   Q962W7;
DT   21-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-JUN-2005, sequence version 2.
DT   25-MAY-2022, entry version 57.
DE   RecName: Full=Fatty-acid and retinol-binding protein 1;
DE   AltName: Full=Ll-FAR-1;
DE   AltName: Full=Ll20;
DE   Flags: Precursor;
GN   Name=far-1 {ECO:0000303|PubMed:12106870};
OS   Loa loa (Eye worm) (Filaria loa).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Loa.
OX   NCBI_TaxID=7209;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:AAK84218.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, AND LACK OF GLYCOSYLATION.
RC   TISSUE=Larva {ECO:0000269|PubMed:12106870};
RX   PubMed=12106870; DOI=10.1016/s0166-6851(02)00097-x;
RA   Garofalo A., Klager S.L., Rowlinson M.C., Nirmalan N., Klion A.D.,
RA   Allen J.E., Kennedy M.W., Bradley J.E.;
RT   "The FAR proteins of filarial nematodes: secretion, glycosylation and lipid
RT   binding characteristics.";
RL   Mol. Biochem. Parasitol. 122:161-170(2002).
CC   -!- FUNCTION: Binds retinol and different fatty acids. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q25619}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in third stage larvae.
CC       {ECO:0000269|PubMed:12106870}.
CC   -!- PTM: Not glycosylated. {ECO:0000269|PubMed:12106870}.
CC   -!- SIMILARITY: Belongs to the fatty-acid and retinol-binding protein
CC       (FARBP) family. {ECO:0000250|UniProtKB:Q25619, ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAK84218.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AF398373; AAK84218.1; ALT_INIT; mRNA.
DR   AlphaFoldDB; Q962W7; -.
DR   SMR; Q962W7; -.
DR   STRING; 7209.EFO23085.2; -.
DR   EnsemblMetazoa; EFO23085.2; EFO23085.2; LOAG_05399.
DR   EnsemblMetazoa; EJD75079.1; EJD75079.1; LOAG_05399.
DR   WBParaSite; EN70_3552; EN70_3552; EN70_3552.
DR   eggNOG; ENOG502S5FJ; Eukaryota.
DR   HOGENOM; CLU_117803_0_0_1; -.
DR   OMA; RKIHAQY; -.
DR   OrthoDB; 1383457at2759; -.
DR   Proteomes; UP000095285; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
DR   GO; GO:0005504; F:fatty acid binding; ISS:UniProtKB.
DR   GO; GO:0016918; F:retinal binding; IEA:UniProtKB-KW.
DR   GO; GO:0019841; F:retinol binding; ISS:UniProtKB.
DR   InterPro; IPR008632; Gp-FAR-1.
DR   PANTHER; PTHR31418; PTHR31418; 1.
DR   Pfam; PF05823; Gp-FAR-1; 1.
PE   1: Evidence at protein level;
KW   Coiled coil; Lipid-binding; Reference proteome; Retinol-binding; Secreted;
KW   Signal; Vitamin A.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000255"
FT   CHAIN           17..178
FT                   /note="Fatty-acid and retinol-binding protein 1"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000008761"
FT   COILED          67..89
FT                   /evidence="ECO:0000255"
FT   COILED          129..154
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   178 AA;  20249 MW;  0993F6710B8D7F7B CRC64;
     MYHQLILLAL IGTIMANVIP FSLSNISEEY KEFIPEEVRN FYKGLTAEDK EILRDLASKH
     ATFANEDAAL EALKDKSDKL YKNAVELRNF VKAKIDSLKP DAKAFVDEVI ARARSLRSDD
     GQKFDTDKIK QAARDIIAKY QALNEETKEE LKVTFPPIAK IISNEKLKRV ASTFLQKN