ID   FAR1_SARBU              Reviewed;           9 AA.
AC   P83350;
DT   10-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT   10-JAN-2003, sequence version 1.
DT   02-JUN-2021, entry version 37.
DE   RecName: Full=FMRFamide-1;
DE   AltName: Full=Neb-FMRFamide-1;
DE   AltName: Full=SabFMRFamide-1;
OS   Sarcophaga bullata (Grey flesh fly) (Neobellieria bullata).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Oestroidea;
OC   Sarcophagidae; Sarcophaga; Neobellieria.
OX   NCBI_TaxID=7385;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, PYROGLUTAMATE FORMATION AT GLN-1, AND AMIDATION
RP   AT PHE-9.
RC   TISSUE=CNS;
RX   PubMed=12438685; DOI=10.1073/pnas.252339599;
RA   Meeusen T., Mertens I., Clynen E., Baggerman G., Nichols R., Nachman R.J.,
RA   Huybrechts R., De Loof A., Schoofs L.;
RT   "Identification in Drosophila melanogaster of the invertebrate G protein-
RT   coupled FMRFamide receptor.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:15363-15368(2002).
RN   [2]
RP   PROTEIN SEQUENCE, MASS SPECTROMETRY, PYROGLUTAMATE FORMATION AT GLN-1, AND
RP   AMIDATION AT PHE-9.
RC   TISSUE=Dorsal ganglionic sheath;
RX   PubMed=18789334; DOI=10.1016/j.ygcen.2008.08.006;
RA   Rahman M.M., Fromm B., Neupert S., Kreusch S., Predel R.;
RT   "Extended FMRFamides in dipteran insects: conservative expression in the
RT   neuroendocrine system is accompanied by rapid sequence evolution.";
RL   Gen. Comp. Endocrinol. 162:52-58(2009).
CC   -!- FUNCTION: Has modulatory actions at skeletal neuromuscular junctions.
CC       {ECO:0000269|PubMed:12438685}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- MASS SPECTROMETRY: Mass=1154.54; Method=MALDI; Note=Without pyrrolidone
CC       carboxylic acid at Gln-1.; Evidence={ECO:0000269|PubMed:18789334};
CC   -!- MASS SPECTROMETRY: Mass=1137.51; Method=MALDI; Note=With pyrrolidone
CC       carboxylic acid at Gln-1.; Evidence={ECO:0000269|PubMed:18789334};
CC   -!- SIMILARITY: Belongs to the FARP (FMRFamide related peptide) family.
CC       {ECO:0000305}.
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Neuropeptide;
KW   Pyrrolidone carboxylic acid; Secreted.
FT   PEPTIDE         1..9
FT                   /note="FMRFamide-1"
FT                   /id="PRO_0000043712"
FT   MOD_RES         1
FT                   /note="Pyrrolidone carboxylic acid; partial"
FT                   /evidence="ECO:0000269|PubMed:12438685,
FT                   ECO:0000269|PubMed:18789334"
FT   MOD_RES         9
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000269|PubMed:12438685,
FT                   ECO:0000269|PubMed:18789334"
SQ   SEQUENCE   9 AA;  1155 MW;  2D810699CAB6C5A7 CRC64;
     QPSQDFMRF