ID   AIM25_YEAST             Reviewed;         327 AA.
AC   P47140; D6VWR9;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   03-AUG-2022, entry version 136.
DE   RecName: Full=Altered inheritance rate of mitochondria protein 25;
GN   Name=AIM25; OrderedLocusNames=YJR100C; ORFNames=J1946;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=8641269; DOI=10.1002/j.1460-2075.1996.tb00557.x;
RA   Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C.,
RA   Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D.,
RA   Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J.,
RA   Heumann K., Hilger F., Hollenberg C.P., Huang M.-E., Jacq C.,
RA   Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E.,
RA   Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T.,
RA   Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B.,
RA   Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R.,
RA   Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N.,
RA   To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H.,
RA   von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.;
RT   "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X.";
RL   EMBO J. 15:2031-2049(1996).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY.
RX   PubMed=14690591; DOI=10.1016/s1097-2765(03)00476-3;
RA   Hazbun T.R., Malmstroem L., Anderson S., Graczyk B.J., Fox B., Riffle M.,
RA   Sundin B.A., Aranda J.D., McDonald W.H., Chiu C.-H., Snydsman B.E.,
RA   Bradley P., Muller E.G.D., Fields S., Baker D., Yates J.R. III, Davis T.N.;
RT   "Assigning function to yeast proteins by integration of technologies.";
RL   Mol. Cell 12:1353-1365(2003).
RN   [4]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS
RP   SPECTROMETRY.
RX   PubMed=16823961; DOI=10.1021/pr050477f;
RA   Reinders J., Zahedi R.P., Pfanner N., Meisinger C., Sickmann A.;
RT   "Toward the complete yeast mitochondrial proteome: multidimensional
RT   separation techniques for mitochondrial proteomics.";
RL   J. Proteome Res. 5:1543-1554(2006).
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:16823961}.
CC   -!- SIMILARITY: Belongs to the phospholipid scramblase family.
CC       {ECO:0000305}.
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DR   EMBL; Z49600; CAA89630.1; -; Genomic_DNA.
DR   EMBL; BK006943; DAA08885.1; -; Genomic_DNA.
DR   PIR; S57121; S57121.
DR   RefSeq; NP_012634.3; NM_001181758.3.
DR   AlphaFoldDB; P47140; -.
DR   BioGRID; 33855; 81.
DR   DIP; DIP-4704N; -.
DR   IntAct; P47140; 2.
DR   STRING; 4932.YJR100C; -.
DR   TCDB; 9.A.36.1.2; the ca(2+)-dependent phospholipid scramblase (scramblase) family.
DR   iPTMnet; P47140; -.
DR   PaxDb; P47140; -.
DR   PRIDE; P47140; -.
DR   EnsemblFungi; YJR100C_mRNA; YJR100C; YJR100C.
DR   GeneID; 853563; -.
DR   KEGG; sce:YJR100C; -.
DR   SGD; S000003861; AIM25.
DR   VEuPathDB; FungiDB:YJR100C; -.
DR   eggNOG; KOG0621; Eukaryota.
DR   GeneTree; ENSGT00940000166503; -.
DR   HOGENOM; CLU_023808_0_1_1; -.
DR   InParanoid; P47140; -.
DR   OMA; QNWHLWR; -.
DR   BioCyc; YEAST:G3O-31728-MON; -.
DR   PRO; PR:P47140; -.
DR   Proteomes; UP000002311; Chromosome X.
DR   RNAct; P47140; protein.
DR   GO; GO:0005739; C:mitochondrion; HDA:SGD.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0017128; F:phospholipid scramblase activity; IBA:GO_Central.
DR   GO; GO:0034605; P:cellular response to heat; IGI:SGD.
DR   GO; GO:0034599; P:cellular response to oxidative stress; IMP:SGD.
DR   GO; GO:1903147; P:negative regulation of autophagy of mitochondrion; IMP:SGD.
DR   GO; GO:0017121; P:plasma membrane phospholipid scrambling; IBA:GO_Central.
DR   InterPro; IPR005552; Scramblase.
DR   PANTHER; PTHR23248; PTHR23248; 1.
DR   Pfam; PF03803; Scramblase; 1.
PE   1: Evidence at protein level;
KW   Mitochondrion; Reference proteome.
FT   CHAIN           1..327
FT                   /note="Altered inheritance rate of mitochondria protein 25"
FT                   /id="PRO_0000203109"
SQ   SEQUENCE   327 AA;  37480 MW;  9861130EB60D75A7 CRC64;
     MHRTAIFLTY RSCMRNFSTL SKTLTVSSGK VIRNGPFRRV IREKNQITKA PSVKAFKENS
     NSGIIKVHDP IATTILNEPT VIIERQIEFM NVFLGFEQAN RYAIMDVNGN KIASMMERDF
     SITKAIMRQF YRLHRPFLVD VFDNWGNVIM TIKRPFSFIN SHIKTIIPPS AYVDNGSDST
     HYHDGKEGTT VGETIQNWHL WRRRYELFQK DGVEGSTFDQ FGKIDAPFLS FDFPVTDADG
     KIMASVDRNW VGLGREMFTD TGVYVVRFDS QRCFDNIYPT EMLSSQVLTL DQRAVLLANA
     VSIDFDYFSR HSRQTGGFLS FGGGYDE