FAR3_YEAST
ID FAR3_YEAST Reviewed; 204 AA.
AC P46671; D6VZM7;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 2.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Factor arrest protein 3;
GN Name=FAR3; OrderedLocusNames=YMR052W; ORFNames=YM9796.05;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=SC252;
RX PubMed=7483842; DOI=10.1002/yea.320110710;
RA Horecka J.;
RT "Localization of the FAR3 gene: genetic mapping and molecular cloning using
RT a chromosome walk-'n'-roll strategy.";
RL Yeast 11:691-696(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169872;
RA Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T.,
RA Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K.,
RA Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P.,
RA Skelton J., Walsh S.V., Whitehead S., Barrell B.G.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII.";
RL Nature 387:90-93(1997).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP FUNCTION, AND INTERACTION WITH FAR7; FAR8; FAR10; FAR11 AND VPS64.
RX PubMed=12588993; DOI=10.1128/mcb.23.5.1750-1763.2003;
RA Kemp H.A., Sprague G.F. Jr.;
RT "Far3 and five interacting proteins prevent premature recovery from
RT pheromone arrest in the budding yeast Saccharomyces cerevisiae.";
RL Mol. Cell. Biol. 23:1750-1763(2003).
RN [5]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
RN [6]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
CC -!- FUNCTION: Participates in the control of the reentry into the cell
CC cycle following pheromone treatment. {ECO:0000269|PubMed:12588993}.
CC -!- SUBUNIT: Component of a complex at least composed of FAR3, FAR7, FAR8,
CC FAR10, FAR11 and VPS64.
CC -!- INTERACTION:
CC P46671; P53917: FAR11; NbExp=2; IntAct=EBI-6789, EBI-28900;
CC P46671; P43592: FAR7; NbExp=6; IntAct=EBI-6789, EBI-22932;
CC P46671; Q05040: FAR8; NbExp=3; IntAct=EBI-6789, EBI-28053;
CC P46671; Q03944: VPS64; NbExp=5; IntAct=EBI-6789, EBI-30418;
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum
CC {ECO:0000269|PubMed:14562095}.
CC -!- MISCELLANEOUS: Present with 1540 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
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DR EMBL; U35609; AAB39035.1; -; Genomic_DNA.
DR EMBL; Z49703; CAA89762.1; -; Genomic_DNA.
DR EMBL; BK006946; DAA09951.1; -; Genomic_DNA.
DR PIR; S54552; S54552.
DR RefSeq; NP_013767.1; NM_001182550.1.
DR AlphaFoldDB; P46671; -.
DR BioGRID; 35228; 261.
DR ComplexPortal; CPX-1197; FAR complex.
DR DIP; DIP-1314N; -.
DR IntAct; P46671; 13.
DR MINT; P46671; -.
DR STRING; 4932.YMR052W; -.
DR iPTMnet; P46671; -.
DR MaxQB; P46671; -.
DR PaxDb; P46671; -.
DR PRIDE; P46671; -.
DR EnsemblFungi; YMR052W_mRNA; YMR052W; YMR052W.
DR GeneID; 855073; -.
DR KEGG; sce:YMR052W; -.
DR SGD; S000004656; FAR3.
DR VEuPathDB; FungiDB:YMR052W; -.
DR eggNOG; ENOG502S56F; Eukaryota.
DR HOGENOM; CLU_116422_0_0_1; -.
DR InParanoid; P46671; -.
DR OMA; SAECRAN; -.
DR BioCyc; YEAST:G3O-32757-MON; -.
DR PRO; PR:P46671; -.
DR Proteomes; UP000002311; Chromosome XIII.
DR RNAct; P46671; protein.
DR GO; GO:0071944; C:cell periphery; HDA:SGD.
DR GO; GO:0005783; C:endoplasmic reticulum; IDA:SGD.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IC:ComplexPortal.
DR GO; GO:0090443; C:FAR/SIN/STRIPAK complex; IC:ComplexPortal.
DR GO; GO:0000137; C:Golgi cis cisterna; IDA:SGD.
DR GO; GO:0071444; P:cellular response to pheromone; IC:ComplexPortal.
DR GO; GO:0000321; P:re-entry into mitotic cell cycle after pheromone arrest; IMP:SGD.
DR GO; GO:0051726; P:regulation of cell cycle; IC:ComplexPortal.
PE 1: Evidence at protein level;
KW Cell cycle; Endoplasmic reticulum; Reference proteome.
FT CHAIN 1..204
FT /note="Factor arrest protein 3"
FT /id="PRO_0000087191"
FT CONFLICT 6
FT /note="S -> T (in Ref. 1; AAB39035)"
FT /evidence="ECO:0000305"
FT CONFLICT 131
FT /note="S -> T (in Ref. 1; AAB39035)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 204 AA; 24032 MW; DCDA9A5713B588B5 CRC64;
MNSGGSDSFD YLLQLTKALS AECRANRQET DRIELLLKRL AKQSGISYDN LSKNIIPDSW
KDNASQKASP PTEAQKLISE NFKLIYEIEK QEYFNTKAVA LINNINEHFS YIKNFIDEQN
AIRERNIATF SSEKLDERNK SLQQNYESLK TENEETKKKL HSIIKQFEKL LKEVDWDRIS
KDSRDYSRFK KQLEYLQDTY QVLK
