ID   AIM2_YEAST              Reviewed;         246 AA.
AC   P39721; D6VPG7;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   03-AUG-2022, entry version 146.
DE   RecName: Full=Protein AIM2;
DE   AltName: Full=Altered inheritance rate of mitochondria protein 2;
GN   Name=AIM2; OrderedLocusNames=YAL049C;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=7731988; DOI=10.1073/pnas.92.9.3809;
RA   Bussey H., Kaback D.B., Zhong W.-W., Vo D.H., Clark M.W., Fortin N.,
RA   Hall J., Ouellette B.F.F., Keng T., Barton A.B., Su Y., Davies C.J.,
RA   Storms R.K.;
RT   "The nucleotide sequence of chromosome I from Saccharomyces cerevisiae.";
RL   Proc. Natl. Acad. Sci. U.S.A. 92:3809-3813(1995).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=17322287; DOI=10.1101/gr.6037607;
RA   Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA   Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA   Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA   Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA   LaBaer J.;
RT   "Approaching a complete repository of sequence-verified protein-encoding
RT   clones for Saccharomyces cerevisiae.";
RL   Genome Res. 17:536-543(2007).
RN   [4]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=14562095; DOI=10.1038/nature02026;
RA   Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA   Weissman J.S., O'Shea E.K.;
RT   "Global analysis of protein localization in budding yeast.";
RL   Nature 425:686-691(2003).
RN   [5]
RP   LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX   PubMed=14562106; DOI=10.1038/nature02046;
RA   Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA   O'Shea E.K., Weissman J.S.;
RT   "Global analysis of protein expression in yeast.";
RL   Nature 425:737-741(2003).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14562095}.
CC   -!- MISCELLANEOUS: Present with 1800 molecules/cell in log phase SD medium.
CC       {ECO:0000269|PubMed:14562106}.
CC   -!- SIMILARITY: Belongs to the AIM2 family. {ECO:0000305}.
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DR   EMBL; U12980; AAC04982.1; -; Genomic_DNA.
DR   EMBL; AY692654; AAT92673.1; -; Genomic_DNA.
DR   EMBL; BK006935; DAA06937.1; -; Genomic_DNA.
DR   PIR; S51970; S51970.
DR   RefSeq; NP_009350.1; NM_001178194.1.
DR   AlphaFoldDB; P39721; -.
DR   SMR; P39721; -.
DR   BioGRID; 31778; 29.
DR   DIP; DIP-2008N; -.
DR   IntAct; P39721; 3.
DR   MINT; P39721; -.
DR   STRING; 4932.YAL049C; -.
DR   ESTHER; yeast-AIM2; Dienelactone_hydrolase.
DR   iPTMnet; P39721; -.
DR   MaxQB; P39721; -.
DR   PaxDb; P39721; -.
DR   PRIDE; P39721; -.
DR   EnsemblFungi; YAL049C_mRNA; YAL049C; YAL049C.
DR   GeneID; 851248; -.
DR   KEGG; sce:YAL049C; -.
DR   SGD; S000000047; AIM2.
DR   VEuPathDB; FungiDB:YAL049C; -.
DR   eggNOG; KOG3043; Eukaryota.
DR   GeneTree; ENSGT00390000000183; -.
DR   HOGENOM; CLU_054590_2_1_1; -.
DR   InParanoid; P39721; -.
DR   OMA; SLCKHCI; -.
DR   BioCyc; YEAST:G3O-28856-MON; -.
DR   PRO; PR:P39721; -.
DR   Proteomes; UP000002311; Chromosome I.
DR   RNAct; P39721; protein.
DR   GO; GO:0005737; C:cytoplasm; HDA:SGD.
DR   GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR002925; Dienelactn_hydro.
DR   Pfam; PF01738; DLH; 1.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Reference proteome.
FT   CHAIN           1..246
FT                   /note="Protein AIM2"
FT                   /id="PRO_0000202423"
SQ   SEQUENCE   246 AA;  27089 MW;  607298D79EECEF5B CRC64;
     MASNQPGKCC FEGVCHDGTP KGRREEIFGL DTYAAGSTSP KEKVIVILTD VYGNKFNNVL
     LTADKFASAG YMVFVPDILF GDAISSDKPI DRDAWFQRHS PEVTKKIVDG FMKLLKLEYD
     PKFIGVVGYC FGAKFAVQHI SGDGGLANAA AIAHPSFVSI EEIEAIDSKK PILISAAEED
     HIFPANLRHL TEEKLKDNHA TYQLDLFSGV AHGFAARGDI SIPAVKYAKE KVLLDQIYWF
     NHFSNV