ID   FARP_ASCSU              Reviewed;         161 AA.
AC   P41854;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 53.
DE   RecName: Full=FMRFamide-like neuropeptides;
DE   Contains:
DE     RecName: Full=Neuropeptide AF10;
DE     AltName: Full=GFGDEMSMPGVLRF-amide;
DE   Contains:
DE     RecName: Full=Neuropeptide AF20;
DE     AltName: Full=GMPGVLRF-amide;
DE   Contains:
DE     RecName: Full=Neuropeptide AF3;
DE     AltName: Full=AVPGVLRF-amide;
DE   Contains:
DE     RecName: Full=Neuropeptide AF4;
DE     AltName: Full=GDVPGVLRF-amide;
DE   Contains:
DE     RecName: Full=Neuropeptide AF13;
DE     AltName: Full=SDMPGVLRF-amide;
DE   Contains:
DE     RecName: Full=Neuropeptide AF14;
DE     AltName: Full=SMPGVLRF-amide;
DE   Flags: Precursor;
GN   Name=AFP-1;
OS   Ascaris suum (Pig roundworm) (Ascaris lumbricoides).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Ascaridomorpha; Ascaridoidea; Ascarididae; Ascaris.
OX   NCBI_TaxID=6253;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND AMIDATION AT PHE-96; PHE-107; PHE-123;
RP   PHE-135; PHE-147 AND PHE-158.
RX   PubMed=9357048; DOI=10.1016/s0196-9781(97)00047-8;
RA   Edison A.S., Messinger L.A., Stretton A.O.W.;
RT   "afp-1: a gene encoding multiple transcripts of a new class of FMRFamide-
RT   like neuropeptides in the nematode Ascaris suum.";
RL   Peptides 18:929-935(1997).
RN   [2]
RP   PROTEIN SEQUENCE OF 83-96; 116-123 AND 127-135, AND AMIDATION AT PHE-96;
RP   PHE-123 AND PHE-135.
RX   PubMed=7651904; DOI=10.1016/0196-9781(94)00211-n;
RA   Cowden C., Stretton A.O.W.;
RT   "Eight novel FMRFamide-like neuropeptides isolated from the nematode
RT   Ascaris suum.";
RL   Peptides 16:491-500(1995).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the FARP (FMRFamide related peptide) family.
CC       {ECO:0000305}.
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DR   EMBL; U15279; AAA50760.1; -; mRNA.
DR   AlphaFoldDB; P41854; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW   Neuropeptide; Repeat; Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   PROPEP          22..80
FT                   /id="PRO_0000009537"
FT   PEPTIDE         83..96
FT                   /note="Neuropeptide AF10"
FT                   /id="PRO_0000009538"
FT   PEPTIDE         100..107
FT                   /note="Neuropeptide AF20"
FT                   /id="PRO_0000009539"
FT   PROPEP          111..113
FT                   /id="PRO_0000009540"
FT   PEPTIDE         116..123
FT                   /note="Neuropeptide AF3"
FT                   /id="PRO_0000009541"
FT   PEPTIDE         127..135
FT                   /note="Neuropeptide AF4"
FT                   /id="PRO_0000009542"
FT   PEPTIDE         139..147
FT                   /note="Neuropeptide AF13"
FT                   /id="PRO_0000009543"
FT   PEPTIDE         151..158
FT                   /note="Neuropeptide AF14"
FT                   /id="PRO_0000009544"
FT   MOD_RES         96
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000269|PubMed:7651904,
FT                   ECO:0000269|PubMed:9357048"
FT   MOD_RES         107
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000269|PubMed:9357048"
FT   MOD_RES         123
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000269|PubMed:7651904,
FT                   ECO:0000269|PubMed:9357048"
FT   MOD_RES         135
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000269|PubMed:7651904,
FT                   ECO:0000269|PubMed:9357048"
FT   MOD_RES         147
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000269|PubMed:9357048"
FT   MOD_RES         158
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000269|PubMed:9357048"
SQ   SEQUENCE   161 AA;  17837 MW;  E17388348ADF0A9A CRC64;
     MVELAAIAVH LFAILCISVS AEIELPDKRA QFDDSFLPYY PSSAFMDSDE AIVAVPSSKP
     GRYYFDQVGL DAENAMSARE KRGFGDEMSM PGVLRFGKRG MPGVLRFGKR ENEKKAVPGV
     LRFGKRGDVP GVLRFGKRSD MPGVLRFGKR SMPGVLRFGR R