FARP_LOCMI
ID FARP_LOCMI Reviewed; 10 AA.
AC P84306; P38553;
DT 07-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT 07-DEC-2004, sequence version 1.
DT 11-DEC-2019, entry version 22.
DE RecName: Full=SchistoFLRFamide;
DE AltName: Full=Cardioexcitatory neuropeptide;
DE AltName: Full=PDVDHFLRF-amide;
OS Locusta migratoria (Migratory locust).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Polyneoptera; Orthoptera; Caelifera; Acrididea; Acridomorpha;
OC Acridoidea; Acrididae; Oedipodinae; Locusta.
OX NCBI_TaxID=7004;
RN [1]
RP PROTEIN SEQUENCE, AMIDATION AT PHE-10, FUNCTION, SUBCELLULAR LOCATION, AND
RP TISSUE SPECIFICITY.
RC TISSUE=Corpora cardiaca;
RX PubMed=7687352; DOI=10.1016/0196-9781(93)90126-2;
RA Schoofs L., Holman G.M., Paemen L., Veelaert D., Amelinckx M., de Loof A.;
RT "Isolation, identification, and synthesis of PDVDHFLRFamide
RT (SchistoFLRFamide) in Locusta migratoria and its association with the male
RT accessory glands, the salivary glands, the heart, and the oviduct.";
RL Peptides 14:409-421(1993).
CC -!- FUNCTION: Muscle inhibiting agent. Involved in the neural control of
CC the visceral muscles of the heart, accessory glands and oviduct. May be
CC involved in the regulation of saliva secretion.
CC {ECO:0000269|PubMed:7687352}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:7687352}.
CC -!- TISSUE SPECIFICITY: Found in axons of the male accessory glands, the
CC salivary glands, the heart, and the oviduct.
CC {ECO:0000269|PubMed:7687352}.
CC -!- SIMILARITY: Belongs to the FARP (FMRFamide related peptide) family.
CC {ECO:0000305}.
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DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Amidation; Direct protein sequencing; Neuropeptide; Secreted.
FT PEPTIDE 1..10
FT /note="SchistoFLRFamide"
FT /id="PRO_0000043682"
FT MOD_RES 10
FT /note="Phenylalanine amide"
FT /evidence="ECO:0000269|PubMed:7687352"
SQ SEQUENCE 10 AA; 1244 MW; D3C51729D2C1EAB2 CRC64;
PDVDHVFLRF