FAS1_CANAX
ID FAS1_CANAX Reviewed; 2037 AA.
AC P34731;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1994, sequence version 1.
DT 25-MAY-2022, entry version 112.
DE RecName: Full=Fatty acid synthase subunit beta;
DE EC=2.3.1.86;
DE Includes:
DE RecName: Full=3-hydroxyacyl-[acyl-carrier-protein] dehydratase;
DE EC=4.2.1.59;
DE Includes:
DE RecName: Full=Enoyl-[acyl-carrier-protein] reductase [NADH];
DE EC=1.3.1.9;
DE Includes:
DE RecName: Full=[Acyl-carrier-protein] acetyltransferase;
DE EC=2.3.1.38;
DE Includes:
DE RecName: Full=[Acyl-carrier-protein] malonyltransferase;
DE EC=2.3.1.39;
DE Includes:
DE RecName: Full=S-acyl fatty acid synthase thioesterase;
DE EC=3.1.2.14;
GN Name=FAS1;
OS Candida albicans (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=5476;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=4918;
RX PubMed=8088535; DOI=10.1016/0378-1119(94)90050-7;
RA Zhao X.-J., Cihlar R.L.;
RT "Isolation and sequence of the Candida albicans FAS1 gene.";
RL Gene 147:119-124(1994).
CC -!- FUNCTION: Fatty acid synthetase catalyzes the formation of long-chain
CC fatty acids from acetyl-CoA, malonyl-CoA and NADPH. The beta subunit
CC contains domains for: [acyl-carrier-protein] acetyltransferase and
CC malonyltransferase, S-acyl fatty acid synthase thioesterase, enoyl-
CC [acyl-carrier-protein] reductase, and 3-hydroxypalmitoyl-[acyl-carrier-
CC protein] dehydratase.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetyl-CoA + 2n H(+) + n malonyl-CoA + 2n NADPH = a long-chain
CC fatty acyl-CoA + n CO2 + n CoA + H2O + 2n NADP(+);
CC Xref=Rhea:RHEA:22896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288,
CC ChEBI:CHEBI:57384, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349,
CC ChEBI:CHEBI:83139; EC=2.3.1.86;
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetyl-CoA + holo-[ACP] = acetyl-[ACP] + CoA;
CC Xref=Rhea:RHEA:41788, Rhea:RHEA-COMP:9621, Rhea:RHEA-COMP:9685,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:64479,
CC ChEBI:CHEBI:78446; EC=2.3.1.38;
CC -!- CATALYTIC ACTIVITY:
CC Reaction=holo-[ACP] + malonyl-CoA = CoA + malonyl-[ACP];
CC Xref=Rhea:RHEA:41792, Rhea:RHEA-COMP:9623, Rhea:RHEA-COMP:9685,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:64479,
CC ChEBI:CHEBI:78449; EC=2.3.1.39;
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O;
CC Xref=Rhea:RHEA:13097, Rhea:RHEA-COMP:9925, Rhea:RHEA-COMP:9945,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:78784, ChEBI:CHEBI:78827; EC=4.2.1.59;
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2,3-saturated acyl-[ACP] + NAD(+) = a (2E)-enoyl-[ACP] +
CC H(+) + NADH; Xref=Rhea:RHEA:10240, Rhea:RHEA-COMP:9925, Rhea:RHEA-
CC COMP:9926, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945,
CC ChEBI:CHEBI:78784, ChEBI:CHEBI:78785; EC=1.3.1.9;
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(9Z)-octadecenoyl-[ACP] + H2O = (9Z)-octadecenoate + H(+) +
CC holo-[ACP]; Xref=Rhea:RHEA:15057, Rhea:RHEA-COMP:9685, Rhea:RHEA-
CC COMP:9924, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823,
CC ChEBI:CHEBI:64479, ChEBI:CHEBI:78783; EC=3.1.2.14;
CC -!- SUBUNIT: [Alpha(6)beta(6)] hexamers of two multifunctional subunits
CC (alpha and beta).
CC -!- SIMILARITY: Belongs to the fungal fatty acid synthetase subunit beta
CC family. {ECO:0000305}.
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DR EMBL; X74952; CAA52907.1; -; Genomic_DNA.
DR PIR; S37178; S37178.
DR PDB; 6U5V; EM; 2.80 A; B=1-2037.
DR PDB; 6U5W; EM; 3.30 A; B=1-2037.
DR PDBsum; 6U5V; -.
DR PDBsum; 6U5W; -.
DR AlphaFoldDB; P34731; -.
DR SMR; P34731; -.
DR PRIDE; P34731; -.
DR VEuPathDB; FungiDB:C5_00190C_A; -.
DR VEuPathDB; FungiDB:CAWG_04414; -.
DR GO; GO:0005835; C:fatty acid synthase complex; IEA:InterPro.
DR GO; GO:0008659; F:(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity; IEA:UniProtKB-EC.
DR GO; GO:0008693; F:3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity; IEA:UniProtKB-EC.
DR GO; GO:0047451; F:3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity; IEA:UniProtKB-EC.
DR GO; GO:0004317; F:3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity; IEA:UniProtKB-EC.
DR GO; GO:0004313; F:[acyl-carrier-protein] S-acetyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0004314; F:[acyl-carrier-protein] S-malonyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0004318; F:enoyl-[acyl-carrier-protein] reductase (NADH) activity; IEA:UniProtKB-EC.
DR GO; GO:0016631; F:enoyl-[acyl-carrier-protein] reductase activity; IEA:UniProtKB-EC.
DR GO; GO:0004321; F:fatty-acyl-CoA synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0016295; F:myristoyl-[acyl-carrier-protein] hydrolase activity; IEA:UniProtKB-EC.
DR GO; GO:0004320; F:oleoyl-[acyl-carrier-protein] hydrolase activity; IEA:UniProtKB-EC.
DR GO; GO:0016296; F:palmitoyl-[acyl-carrier-protein] hydrolase activity; IEA:UniProtKB-EC.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW.
DR Gene3D; 3.20.20.70; -; 2.
DR Gene3D; 3.40.366.10; -; 3.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR016452; Fas1/AflB-like.
DR InterPro; IPR013565; Fas1/AflB-like_central.
DR InterPro; IPR041099; FAS1_N.
DR InterPro; IPR040883; FAS_meander.
DR InterPro; IPR003965; Fatty_acid_synthase.
DR InterPro; IPR029069; HotDog_dom_sf.
DR InterPro; IPR039569; MaoC-like_dehydrat_N.
DR InterPro; IPR002539; MaoC-like_dom.
DR InterPro; IPR032088; SAT.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF08354; DUF1729; 1.
DR Pfam; PF17951; FAS_meander; 1.
DR Pfam; PF17828; FAS_N; 1.
DR Pfam; PF13452; MaoC_dehydrat_N; 1.
DR Pfam; PF01575; MaoC_dehydratas; 1.
DR Pfam; PF16073; SAT; 1.
DR PIRSF; PIRSF005562; FAS_yeast_beta; 1.
DR PRINTS; PR01483; FASYNTHASE.
DR SMART; SM00827; PKS_AT; 1.
DR SUPFAM; SSF52151; SSF52151; 2.
DR SUPFAM; SSF54637; SSF54637; 2.
PE 1: Evidence at protein level;
KW 3D-structure; Fatty acid biosynthesis; Fatty acid metabolism; Hydrolase;
KW Lipid biosynthesis; Lipid metabolism; Lyase; Multifunctional enzyme; NAD;
KW NADP; Oxidoreductase; Transferase.
FT CHAIN 1..2037
FT /note="Fatty acid synthase subunit beta"
FT /id="PRO_0000180280"
FT DOMAIN 1506..1634
FT /note="MaoC-like"
FT REGION 1..453
FT /note="Acetyltransferase"
FT /evidence="ECO:0000250"
FT REGION 465..798
FT /note="Enoyl reductase"
FT /evidence="ECO:0000250"
FT REGION 1132..1612
FT /note="Dehydratase"
FT /evidence="ECO:0000250"
FT REGION 1613..1833
FT /note="Malonyl/palmitoyl transferase"
FT /evidence="ECO:0000250"
FT ACT_SITE 261
FT /note="For acetyltransferase activity"
FT /evidence="ECO:0000250"
FT ACT_SITE 1796
FT /note="For malonyltransferase activity"
FT /evidence="ECO:0000250"
FT STRAND 6..11
FT /evidence="ECO:0007829|PDB:6U5V"
FT STRAND 14..19
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 22..24
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 25..35
FT /evidence="ECO:0007829|PDB:6U5V"
FT TURN 44..46
FT /evidence="ECO:0007829|PDB:6U5V"
FT STRAND 49..51
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 55..65
FT /evidence="ECO:0007829|PDB:6U5V"
FT TURN 66..68
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 75..86
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 94..101
FT /evidence="ECO:0007829|PDB:6U5V"
FT STRAND 105..107
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 112..115
FT /evidence="ECO:0007829|PDB:6U5V"
FT TURN 116..118
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 119..125
FT /evidence="ECO:0007829|PDB:6U5V"
FT TURN 137..139
FT /evidence="ECO:0007829|PDB:6U5V"
FT TURN 141..143
FT /evidence="ECO:0007829|PDB:6U5V"
FT STRAND 146..150
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 160..169
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 171..186
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 190..192
FT /evidence="ECO:0007829|PDB:6U5V"
FT TURN 193..195
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 202..207
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 209..211
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 215..218
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 221..242
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 247..250
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 251..253
FT /evidence="ECO:0007829|PDB:6U5V"
FT STRAND 254..259
FT /evidence="ECO:0007829|PDB:6U5V"
FT TURN 261..263
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 264..272
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 276..287
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 289..300
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 308..316
FT /evidence="ECO:0007829|PDB:6U5V"
FT STRAND 324..331
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 333..343
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 344..346
FT /evidence="ECO:0007829|PDB:6U5V"
FT STRAND 354..358
FT /evidence="ECO:0007829|PDB:6U5V"
FT STRAND 360..368
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 370..383
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 387..389
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 391..393
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 396..398
FT /evidence="ECO:0007829|PDB:6U5V"
FT STRAND 405..407
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 417..419
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 420..432
FT /evidence="ECO:0007829|PDB:6U5V"
FT STRAND 447..449
FT /evidence="ECO:0007829|PDB:6U5V"
FT STRAND 452..455
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 461..468
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 475..478
FT /evidence="ECO:0007829|PDB:6U5V"
FT STRAND 484..488
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 493..495
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 497..504
FT /evidence="ECO:0007829|PDB:6U5V"
FT TURN 505..507
FT /evidence="ECO:0007829|PDB:6U5V"
FT STRAND 511..514
FT /evidence="ECO:0007829|PDB:6U5V"
FT STRAND 527..529
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 530..533
FT /evidence="ECO:0007829|PDB:6U5V"
FT STRAND 538..541
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 548..551
FT /evidence="ECO:0007829|PDB:6U5V"
FT STRAND 555..558
FT /evidence="ECO:0007829|PDB:6U5V"
FT STRAND 564..567
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 569..574
FT /evidence="ECO:0007829|PDB:6U5V"
FT STRAND 578..581
FT /evidence="ECO:0007829|PDB:6U5V"
FT TURN 585..589
FT /evidence="ECO:0007829|PDB:6U5V"
FT TURN 591..601
FT /evidence="ECO:0007829|PDB:6U5V"
FT STRAND 604..607
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 608..610
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 614..625
FT /evidence="ECO:0007829|PDB:6U5V"
FT STRAND 634..639
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 645..659
FT /evidence="ECO:0007829|PDB:6U5V"
FT STRAND 662..670
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 675..683
FT /evidence="ECO:0007829|PDB:6U5V"
FT STRAND 688..692
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 697..707
FT /evidence="ECO:0007829|PDB:6U5V"
FT STRAND 715..719
FT /evidence="ECO:0007829|PDB:6U5V"
FT STRAND 722..727
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 734..738
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 741..744
FT /evidence="ECO:0007829|PDB:6U5V"
FT STRAND 750..754
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 761..769
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 773..775
FT /evidence="ECO:0007829|PDB:6U5V"
FT STRAND 784..789
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 792..794
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 802..810
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 816..818
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 820..823
FT /evidence="ECO:0007829|PDB:6U5V"
FT STRAND 830..834
FT /evidence="ECO:0007829|PDB:6U5V"
FT STRAND 836..838
FT /evidence="ECO:0007829|PDB:6U5V"
FT STRAND 840..844
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 847..858
FT /evidence="ECO:0007829|PDB:6U5V"
FT TURN 859..861
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 864..866
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 867..873
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 875..884
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 901..903
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 906..917
FT /evidence="ECO:0007829|PDB:6U5V"
FT TURN 920..923
FT /evidence="ECO:0007829|PDB:6U5V"
FT STRAND 924..926
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 928..945
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 958..962
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 964..971
FT /evidence="ECO:0007829|PDB:6U5V"
FT TURN 972..974
FT /evidence="ECO:0007829|PDB:6U5V"
FT TURN 976..980
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 988..995
FT /evidence="ECO:0007829|PDB:6U5V"
FT STRAND 1004..1006
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 1014..1017
FT /evidence="ECO:0007829|PDB:6U5V"
FT TURN 1018..1022
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 1023..1026
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 1028..1030
FT /evidence="ECO:0007829|PDB:6U5V"
FT STRAND 1031..1033
FT /evidence="ECO:0007829|PDB:6U5W"
FT HELIX 1036..1038
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 1047..1050
FT /evidence="ECO:0007829|PDB:6U5V"
FT STRAND 1053..1055
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 1058..1077
FT /evidence="ECO:0007829|PDB:6U5V"
FT STRAND 1092..1094
FT /evidence="ECO:0007829|PDB:6U5W"
FT STRAND 1100..1102
FT /evidence="ECO:0007829|PDB:6U5W"
FT HELIX 1103..1105
FT /evidence="ECO:0007829|PDB:6U5V"
FT STRAND 1110..1115
FT /evidence="ECO:0007829|PDB:6U5V"
FT STRAND 1118..1120
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 1123..1129
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 1137..1143
FT /evidence="ECO:0007829|PDB:6U5V"
FT STRAND 1145..1151
FT /evidence="ECO:0007829|PDB:6U5V"
FT STRAND 1153..1155
FT /evidence="ECO:0007829|PDB:6U5W"
FT HELIX 1158..1161
FT /evidence="ECO:0007829|PDB:6U5V"
FT STRAND 1169..1173
FT /evidence="ECO:0007829|PDB:6U5V"
FT TURN 1174..1177
FT /evidence="ECO:0007829|PDB:6U5V"
FT STRAND 1178..1185
FT /evidence="ECO:0007829|PDB:6U5V"
FT STRAND 1188..1198
FT /evidence="ECO:0007829|PDB:6U5V"
FT TURN 1199..1201
FT /evidence="ECO:0007829|PDB:6U5V"
FT STRAND 1202..1209
FT /evidence="ECO:0007829|PDB:6U5V"
FT STRAND 1218..1221
FT /evidence="ECO:0007829|PDB:6U5V"
FT STRAND 1224..1226
FT /evidence="ECO:0007829|PDB:6U5V"
FT STRAND 1231..1233
FT /evidence="ECO:0007829|PDB:6U5V"
FT STRAND 1235..1237
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 1242..1254
FT /evidence="ECO:0007829|PDB:6U5V"
FT STRAND 1267..1269
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 1280..1290
FT /evidence="ECO:0007829|PDB:6U5V"
FT TURN 1295..1297
FT /evidence="ECO:0007829|PDB:6U5W"
FT HELIX 1309..1311
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 1312..1315
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 1317..1320
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 1321..1323
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 1333..1335
FT /evidence="ECO:0007829|PDB:6U5V"
FT STRAND 1340..1345
FT /evidence="ECO:0007829|PDB:6U5V"
FT STRAND 1353..1355
FT /evidence="ECO:0007829|PDB:6U5V"
FT STRAND 1357..1370
FT /evidence="ECO:0007829|PDB:6U5V"
FT STRAND 1373..1384
FT /evidence="ECO:0007829|PDB:6U5V"
FT STRAND 1387..1400
FT /evidence="ECO:0007829|PDB:6U5V"
FT STRAND 1409..1413
FT /evidence="ECO:0007829|PDB:6U5V"
FT STRAND 1417..1420
FT /evidence="ECO:0007829|PDB:6U5V"
FT STRAND 1423..1425
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 1426..1430
FT /evidence="ECO:0007829|PDB:6U5V"
FT STRAND 1436..1438
FT /evidence="ECO:0007829|PDB:6U5V"
FT STRAND 1445..1461
FT /evidence="ECO:0007829|PDB:6U5V"
FT STRAND 1463..1475
FT /evidence="ECO:0007829|PDB:6U5V"
FT STRAND 1481..1496
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 1498..1505
FT /evidence="ECO:0007829|PDB:6U5V"
FT STRAND 1506..1509
FT /evidence="ECO:0007829|PDB:6U5V"
FT STRAND 1514..1522
FT /evidence="ECO:0007829|PDB:6U5V"
FT STRAND 1529..1531
FT /evidence="ECO:0007829|PDB:6U5W"
FT HELIX 1537..1543
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 1548..1551
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 1553..1558
FT /evidence="ECO:0007829|PDB:6U5V"
FT STRAND 1562..1564
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 1568..1582
FT /evidence="ECO:0007829|PDB:6U5V"
FT TURN 1583..1586
FT /evidence="ECO:0007829|PDB:6U5W"
FT STRAND 1590..1598
FT /evidence="ECO:0007829|PDB:6U5V"
FT STRAND 1607..1618
FT /evidence="ECO:0007829|PDB:6U5V"
FT STRAND 1621..1630
FT /evidence="ECO:0007829|PDB:6U5V"
FT TURN 1631..1633
FT /evidence="ECO:0007829|PDB:6U5V"
FT STRAND 1636..1644
FT /evidence="ECO:0007829|PDB:6U5V"
FT STRAND 1649..1653
FT /evidence="ECO:0007829|PDB:6U5V"
FT TURN 1661..1664
FT /evidence="ECO:0007829|PDB:6U5W"
FT HELIX 1665..1669
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 1672..1685
FT /evidence="ECO:0007829|PDB:6U5V"
FT TURN 1686..1689
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 1693..1698
FT /evidence="ECO:0007829|PDB:6U5V"
FT STRAND 1702..1707
FT /evidence="ECO:0007829|PDB:6U5V"
FT TURN 1711..1713
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 1714..1722
FT /evidence="ECO:0007829|PDB:6U5V"
FT STRAND 1737..1739
FT /evidence="ECO:0007829|PDB:6U5W"
FT STRAND 1742..1744
FT /evidence="ECO:0007829|PDB:6U5V"
FT STRAND 1749..1753
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 1758..1760
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 1762..1782
FT /evidence="ECO:0007829|PDB:6U5V"
FT STRAND 1791..1794
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 1798..1803
FT /evidence="ECO:0007829|PDB:6U5V"
FT TURN 1804..1806
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 1812..1827
FT /evidence="ECO:0007829|PDB:6U5V"
FT STRAND 1839..1845
FT /evidence="ECO:0007829|PDB:6U5V"
FT TURN 1847..1850
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 1856..1870
FT /evidence="ECO:0007829|PDB:6U5V"
FT STRAND 1874..1881
FT /evidence="ECO:0007829|PDB:6U5V"
FT TURN 1882..1884
FT /evidence="ECO:0007829|PDB:6U5V"
FT STRAND 1885..1891
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 1892..1907
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 1915..1918
FT /evidence="ECO:0007829|PDB:6U5V"
FT TURN 1923..1928
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 1929..1940
FT /evidence="ECO:0007829|PDB:6U5V"
FT STRAND 1952..1956
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 1967..1972
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 1973..1983
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 1986..1988
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 1991..1993
FT /evidence="ECO:0007829|PDB:6U5V"
FT TURN 1994..1997
FT /evidence="ECO:0007829|PDB:6U5V"
FT STRAND 2001..2003
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 2011..2021
FT /evidence="ECO:0007829|PDB:6U5V"
FT HELIX 2025..2031
FT /evidence="ECO:0007829|PDB:6U5V"
FT TURN 2033..2036
FT /evidence="ECO:0007829|PDB:6U5V"
SQ SEQUENCE 2037 AA; 227919 MW; D37BDD0DB9A8ADDA CRC64;
MSTHRPFQLT HGSIEHTLLV PNDLFFNYSQ LKDEFIKTLP EPTEGFAGDD EPSSPAELYG
KFIGFISNAQ FPQIVELSLK DFESRFLDNN NDNIHSFAVK LLDDETYPTT IAKVKENIVK
NYYKAVKSIN KVESNLLYHC KHDAKLVAIF GGQGNTDDYF EELRELYTLY QGLIEDLLVS
IAEKLNQLHP SFDKIYTQGL NILSWLKHPE TTPDQDYLLS VPVSCPVICV IQLCHYTITC
KVLGLTPGEF RNSLKWSTGH SQGLVTAVTI AASDSWDSFL KNSLTAVSLL LFIGSRCLST
YPRTSLPPTM LQDSLDNGEG RPSPMLSVRD LSIKQVEKFI EQTNSHLPRE KHIAISLING
ARNLVLSGPP ESLYGFNLNL RNQKAPMGLD QSRVPFSERK LKCSNRFLPI FAPFHSHLLA
DATELILDDV KEHGLSFEGL KIPVYDTFDG SDFQALKEPI IDRVVKLITE LPVHWEEATN
HKATHILDFG PGGVSGLGVL THRNKEGTGA RIILAGTLDS NPIDDEYGFK HEIFQTSADK
AIKWAPDWLK ELRPTLVKNS EGKIYVKTKF SQLLGRAPLM VAGMTPTTVN TDIVSASLNA
GYHIELAGGG YFSPVMMTRA IDDIVSRIKP GYGLGINLIY VNPFMLQWGI PLIKDLREKG
YPIQSLTIGA GVPSIEVATE YIEDLGLTHL GLKPGSVDAI SQVIAIAKAH PTFPIVLQWT
GGRGGGHHSF EDFHQPIIQM YSKIRRCSNI VLVAGSGFGS DEDTYPYLSG YWSEKFNYPP
MPFDGVLFGS RVMTSKESHT SLAAKKLIVE CKGVPDQQWE QTYKKPTGGI ITVRSEMGEP
IHKIATRGVM FWKELDDTIF NLPKNKLLDA LNKKRDHIIK KLNNDFQKPW FGKNANGVCD
LQEMTYKEVA NRLVELMYVK KSHRWIDVSL RNMYGDFLRR VEERFTSSAG TVSLLQNFNQ
LNEPEQFTAD FFEKFPQAGK QLISEEDCDY FLMLAARPGQ KPVPFVPVLD ERFEFFFKKD
SLWQSEDLES VVDEDVQRTC ILHGPVASQY TSKVDEPIGD ILNSIHEGHI ARLIKEEYAG
DESKIPVVEY FGGKKPASVS ATSVNIIDGN QVVYEIDSEL PNKQEWLDLL AGTELNWLQA
FISTDRIVQG SKHVSNPLHD ILTPAKHSKV TIDKKTKKLT AFENIKGDLL PVVEIELVKP
NTIQLSLIEH RTADTNPVAL PFLYKYNPAD GFAPILEIME DRNERIKEFY WKLWFGSSVP
YSNDINVEKA ILGDEITISS QTISEFTHAI GNKCDAFVDR PGKATLAPMD FAIVIGWKAI
IKAIFPKSVD GDLLKLVHLS NGYKMITGAA PLKKGDVVST KAEIKAVLNQ PSGKLVEVVG
TIYREGKPVM EVTSQFLYRG EYNDYCNTFQ KVTETPVQVA FKSAKDLAVL RSKEWFHLEK
DVQFDVLTFR CESTYKFKSA NVYSSIKTTG QVLLELPTKE VIQVGSVDYE AGTSYGNPVT
DYLSRNGKTI EESVIFENAI PLSSGEELTS KAPGTNEPYA IVSGDYNPIH VSRVFAAYAK
LPGTITHGMY SSASIRALVE EWAANNVAAR VRAFKCDFVG MVLPNDTLQT TMEHVGMING
RKIIKVETRN VETELPVLIG EAEIEQPTTT YVFTGQGSQE QGMGMELYNS SEVAREVWDK
ADRHFVNNYG FSILDIVQNN PNELTIHFGG AKGRAIRDNY IGMMFETIGE DGALKSEKIF
KDIDETTTSY TFVSPTGLLS ATQFTQPALT LMEKAAYEDI KSKGLIPSDI MFAGHSLGEY
SALSSLANVM PIESLVDVVF YRGMTMQVAV PRDELGRSNY GMVAVNPSRV SATFDDSALR
FVVDEVANKT KWLLEIVNYN VENQQYVAAG DLRALDTLTN VLNVLKINKI DIVKLQEQMS
IEKVKEHLYE IVDEVAAKSL AKPQPIDLER GFAVIPLKGI SVPFHSSYLM SGVKPFQRFL
CKKIPKSSVK PQDLIGKYIP NLTAKPFELT KEYFQSVYDL TKSEKIKSIL DNWEQYE
