AIM33_YEAST
ID AIM33_YEAST Reviewed; 312 AA.
AC Q04516; D6W0J6;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Uncharacterized oxidoreductase AIM33;
DE EC=1.-.-.-;
DE AltName: Full=Altered inheritance of mitochondria protein 33;
GN Name=AIM33; OrderedLocusNames=YML087C;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169872;
RA Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T.,
RA Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K.,
RA Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P.,
RA Skelton J., Walsh S.V., Whitehead S., Barrell B.G.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII.";
RL Nature 387:90-93(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 208353 / W303-1A;
RX PubMed=16847258; DOI=10.1073/pnas.0604075103;
RA Kim H., Melen K., Oesterberg M., von Heijne G.;
RT "A global topology map of the Saccharomyces cerevisiae membrane proteome.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006).
RN [4]
RP DISRUPTION PHENOTYPE.
RX PubMed=19300474; DOI=10.1371/journal.pgen.1000407;
RA Hess D.C., Myers C.L., Huttenhower C., Hibbs M.A., Hayes A.P., Paw J.,
RA Clore J.J., Mendoza R.M., Luis B.S., Nislow C., Giaever G., Costanzo M.,
RA Troyanskaya O.G., Caudy A.A.;
RT "Computationally driven, quantitative experiments discover genes required
RT for mitochondrial biogenesis.";
RL PLoS Genet. 5:E1000407-E1000407(2009).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- DISRUPTION PHENOTYPE: Increases frequency of mitochondrial genome loss.
CC {ECO:0000269|PubMed:19300474}.
CC -!- SIMILARITY: Belongs to the flavoprotein pyridine nucleotide cytochrome
CC reductase family. {ECO:0000305}.
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DR EMBL; Z46660; CAA86651.1; -; Genomic_DNA.
DR EMBL; BK006946; DAA09810.1; -; Genomic_DNA.
DR PIR; S49640; S49640.
DR RefSeq; NP_013623.1; NM_001182446.1.
DR AlphaFoldDB; Q04516; -.
DR SMR; Q04516; -.
DR BioGRID; 35054; 106.
DR STRING; 4932.YML087C; -.
DR PaxDb; Q04516; -.
DR PRIDE; Q04516; -.
DR EnsemblFungi; YML087C_mRNA; YML087C; YML087C.
DR GeneID; 854887; -.
DR KEGG; sce:YML087C; -.
DR SGD; S000004552; AIM33.
DR VEuPathDB; FungiDB:YML087C; -.
DR eggNOG; KOG0534; Eukaryota.
DR GeneTree; ENSGT00940000176475; -.
DR HOGENOM; CLU_003827_9_0_1; -.
DR InParanoid; Q04516; -.
DR OMA; DHMAKEY; -.
DR BioCyc; YEAST:G3O-32675-MON; -.
DR PRO; PR:Q04516; -.
DR Proteomes; UP000002311; Chromosome XIII.
DR RNAct; Q04516; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.80; -; 1.
DR InterPro; IPR001834; CBR-like.
DR InterPro; IPR008333; Cbr1-like_FAD-bd_dom.
DR InterPro; IPR017927; FAD-bd_FR_type.
DR InterPro; IPR001709; Flavoprot_Pyr_Nucl_cyt_Rdtase.
DR InterPro; IPR039261; FNR_nucleotide-bd.
DR InterPro; IPR001433; OxRdtase_FAD/NAD-bd.
DR InterPro; IPR017938; Riboflavin_synthase-like_b-brl.
DR PANTHER; PTHR19370; PTHR19370; 1.
DR Pfam; PF00970; FAD_binding_6; 1.
DR Pfam; PF00175; NAD_binding_1; 1.
DR PRINTS; PR00371; FPNCR.
DR SUPFAM; SSF52343; SSF52343; 1.
DR SUPFAM; SSF63380; SSF63380; 1.
DR PROSITE; PS51384; FAD_FR; 1.
PE 1: Evidence at protein level;
KW FAD; Flavoprotein; Membrane; NAD; Oxidoreductase; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..312
FT /note="Uncharacterized oxidoreductase AIM33"
FT /id="PRO_0000167629"
FT TOPO_DOM 1..14
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 15..35
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 36..41
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 42..62
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 63..179
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 180..200
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 201..312
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 70..173
FT /note="FAD-binding FR-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00716"
SQ SEQUENCE 312 AA; 35764 MW; F64DEA3033124EE4 CRC64;
MSIVETCISF VSTNPFYPFC TGLLLNCVVT PLYFWKTQNG RIVVVSLLQF VVLYATAFIS
IGTDKSLYRN KWVALPLSKK TRISRNTSLY CFKLKYPFER LHIPMGYHLA VRVTINGERL
VRYYTPVNVP NTEGHLELVV KTYKHGVVSK YFDKLKIRQY VEFKGPLGEL EYDQDTATEL
GIIAGGSGIT PVLQVLQEII PSPEDLTHIS LIYANETEDD ILMKSQLDHM AKEYPHFKVH
YVIHKPNGKW NGDVGYVTLE EMKRYLPKQA EDHRLLICGP PKMNEMVLNY AKELGWSNGF
HKGNGTDKVF VF
