FATC_VIBA7
ID FATC_VIBA7 Reviewed; 317 AA.
AC P37737;
DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1994, sequence version 1.
DT 25-MAY-2022, entry version 106.
DE RecName: Full=Ferric-anguibactin transport system permease protein FatC {ECO:0000305};
GN Name=fatC {ECO:0000303|PubMed:1748657};
OS Vibrio anguillarum (strain ATCC 68554 / 775) (Listonella anguillarum).
OG Plasmid pJM1.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio.
OX NCBI_TaxID=882102;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], DISRUPTION PHENOTYPE, FUNCTION, AND
RP SUBUNIT.
RC STRAIN=ATCC 68554 / 775;
RX PubMed=1748657; DOI=10.1016/s0021-9258(18)54358-1;
RA Koester W.L., Actis L.A., Waldbeser L.S., Tolmasky M.E., Crosa J.H.;
RT "Molecular characterization of the iron transport system mediated by the
RT pJM1 plasmid in Vibrio anguillarum 775.";
RL J. Biol. Chem. 266:23829-23833(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 68554 / 775;
RX PubMed=13129954; DOI=10.1128/jb.185.19.5822-5830.2003;
RA Di Lorenzo M., Stork M., Tolmasky M.E., Actis L.A., Farrell D., Welch T.J.,
RA Crosa L.M., Wertheimer A.M., Chen Q., Salinas P., Waldbeser L., Crosa J.H.;
RT "Complete sequence of virulence plasmid pJM1 from the marine fish pathogen
RT Vibrio anguillarum strain 775.";
RL J. Bacteriol. 185:5822-5830(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 68554 / 775;
RX PubMed=21576332; DOI=10.1128/iai.05138-11;
RA Naka H., Dias G.M., Thompson C.C., Dubay C., Thompson F.L., Crosa J.H.;
RT "Complete genome sequence of the marine fish pathogen Vibrio anguillarum
RT harboring the pJM1 virulence plasmid and genomic comparison with other
RT virulent strains of V. anguillarum and V. ordalii.";
RL Infect. Immun. 79:2889-2900(2011).
RN [4]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RC STRAIN=ATCC 68554 / 775;
RX PubMed=21304833; DOI=10.1111/j.1758-2229.2009.00110.x;
RA Naka H., Lopez C.S., Crosa J.H.;
RT "Role of the pJM1 plasmid-encoded transport proteins FatB, C and D in
RT ferric anguibactin uptake in the fish pathogen Vibrio anguillarum.";
RL Environ. Microbiol. Rep. 2:104-111(2010).
CC -!- FUNCTION: Involved in the uptake of iron in complex with the
CC siderophore anguibactin. Responsible for the translocation of ferric-
CC anguibactin across the cytoplasmic membrane.
CC {ECO:0000269|PubMed:1748657, ECO:0000269|PubMed:21304833}.
CC -!- SUBUNIT: Part of an iron transport system composed of the outer
CC membrane receptor FatA, the periplasmic binding protein FatB and the
CC inner membrane proteins FatC and FatD. {ECO:0000305|PubMed:1748657}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC membrane protein {ECO:0000255}.
CC -!- DISRUPTION PHENOTYPE: Mutants cannot transport ferric-anguibactin and
CC are unable to grow under iron-limiting conditions.
CC {ECO:0000269|PubMed:1748657, ECO:0000269|PubMed:21304833}.
CC -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC permease family. FecCD subfamily. {ECO:0000305}.
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DR EMBL; AY312585; AAR12525.1; -; Genomic_DNA.
DR PIR; B41671; B41671.
DR RefSeq; NP_943550.1; NC_005250.1.
DR RefSeq; WP_011154636.1; NC_005250.1.
DR AlphaFoldDB; P37737; -.
DR SMR; P37737; -.
DR eggNOG; COG4605; Bacteria.
DR OMA; AIMGYEA; -.
DR Proteomes; UP000006800; Plasmid pJM1.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR Gene3D; 1.10.3470.10; -; 1.
DR InterPro; IPR037294; ABC_BtuC-like.
DR InterPro; IPR000522; ABC_transptr_permease_BtuC.
DR PANTHER; PTHR30472; PTHR30472; 1.
DR Pfam; PF01032; FecCD; 1.
DR SUPFAM; SSF81345; SSF81345; 1.
PE 1: Evidence at protein level;
KW Cell inner membrane; Cell membrane; Ion transport; Iron; Iron transport;
KW Membrane; Plasmid; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..317
FT /note="Ferric-anguibactin transport system permease protein
FT FatC"
FT /id="PRO_0000060013"
FT TRANSMEM 10..30
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 39..59
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 72..92
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 133..153
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 177..197
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 228..248
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 268..288
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 291..311
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 317 AA; 34930 MW; 921E864865680877 CRC64;
MTSLNLNFRV SVVLVILLSI AFIFINSGFD LEYIIPRRLI KLSAIIIGGS CVAISAVIFQ
ALARNRILTP SIMGYESIYL VWQALLLLFV GTSGSAVLGV VGNFVVSAVL ILLYSFVIQF
WVLKRFQHDM HQVLLIGFVL TMVLTTVAQF IQIRISPGEF SIFQGLSYTS FERAKPSTLL
FAGTVLSILA LFANKWVSEL DVIGLGRDQA MSLGLNDAHY IPKYFSVIAI LVAISTSLIG
PTAFMGVFIA NIAYSITGSP QYRHTLPVAC TIAIVMFLTA QLMVEHFFNY KTTVSILVNV
LCGGYFLIIT MRARSQL
